CHAPTER 15. Biologically Active N-Heterocyclic Carbene–Metal Complexes

Wagers, Patrick O.; Panzner, Matthew J.; Southerland, Marie R.; DeBord, Michael A.; Deblock, Michael C.; Tessier, Claire A.; Cannon, Carolyn L.; Youngs, Wiley J.

doi:10.1039/9781782626817-00567

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“…Beginning with the successful isolation of the first stable N -heterocyclic carbene (NHC) by Arduengo in 1991 [ 1 ], NHCs have become a staple in research laboratories throughout the world. NHCs started as a mere laboratory curiosity but have evolved into a versatile organic ligand that has been used in a variety of capacities [ 2 ]. This is mainly due to their unparalleled structural diversity, as NHCs can be substituted with a variety of functional groups at various positions on the NHC core.…”

Section: Introductionmentioning

confidence: 99%

Recent Developments in the Medicinal Applications of Silver-NHC Complexes and Imidazolium Salts

2017

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Because of their great structural diversity and multitude of chemical properties, N-heterocyclic carbenes (NHCs) have been utilized in a variety of capacities. Most recently, NHCs have been utilized as carrier molecules for many transition metals in medicinal chemistry. Specifically, Ag(I)-NHCs have been investigated as potent antibacterial agents and chemotherapeutics and have shown great efficacy in both in vitro and in vivo studies. Ag(I)-NHC compounds have been shown to be effective against a wide range of both Gram-positive and Gram-negative bacterial strains. Many compounds have also shown great efficacy as antitumor agents demonstrating comparable or better antitumor activity than standard chemotherapeutics such as cisplatin and 5-fluorouracil. While these compounds have shown great promise, clinical use has remained an unattained goal. Current research has been focused upon synthesis of novel Ag(I)-NHC compounds and further investigations of their antibacterial and antitumor activity. This review will focus on recent advances of Ag(I)-NHCs in medicinal applications.

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Section: Introductionmentioning

confidence: 99%