Chapter 10 Current trends on herbal bioenhancers

Kulkarni, Deepak; Surwase, Sachin S.; Musale, Shubham; Giram, Prabhanjan S.

doi:10.1515/9783110746808-010

Cited by 3 publications

(4 citation statements)

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“…Examples of bioenhancers of natural origin are, e.g., grapefruit juice, citric acid, aloe vera, flavonoid curcumin, menthol, and eicosapentaenoic fatty acid. These are, among many others, applied as excipients in different final drug products in traditional pharmacology [ 17 , 18 ].…”

Section: Possible Pharmacological Mechanisms Involved In the ‘Entoura...mentioning

confidence: 99%

Decoding the Postulated Entourage Effect of Medicinal Cannabis: What It Is and What It Isn’t

Christensen,

Rose,

Cornett

et al. 2023

Biomedicines

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The ‘entourage effect’ term was originally coined in a pre-clinical study observing endogenous bio-inactive metabolites potentiating the activity of a bioactive endocannabinoid. As a hypothetical afterthought, this was proposed to hold general relevance to the usage of products based on Cannabis sativa L. The term was later juxtaposed to polypharmacy pertaining to full-spectrum medicinal Cannabis products exerting an overall higher effect than the single compounds. Since the emergence of the term, a discussion of its pharmacological foundation and relevance has been ongoing. Advocates suggest that the ‘entourage effect’ is the reason many patients experience an overall better effect from full-spectrum products. Critics state that the term is unfounded and used primarily for marketing purposes in the Cannabis industry. This scoping review aims to segregate the primary research claiming as well as disputing the existence of the ‘entourage effect’ from a pharmacological perspective. The literature on this topic is in its infancy. Existing pre-clinical and clinical studies are in general based on simplistic methodologies and show contradictory findings, with the clinical data mostly relying on anecdotal and real-world evidence. We propose that the ‘entourage effect’ is explained by traditional pharmacological terms pertaining to other plant-based medicinal products and polypharmacy in general (e.g., synergistic interactions and bioenhancement).

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Section: Possible Pharmacological Mechanisms Involved In the ‘Entoura...mentioning

confidence: 99%

Decoding the Postulated Entourage Effect of Medicinal Cannabis: What It Is and What It Isn’t

Christensen,

Rose,

Cornett

et al. 2023

Biomedicines

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show abstract

“…Bioenhancers will diminish the poisonousness and abbreviate the treatment time frame. Immunomodulation and hepatoprotective properties might be further advantages in treating tuberculosis [9][10][11][12]. Quercetin, an aglycone type of flavonoid glycosides, is found in natural citrus products.…”

Section: Introductionmentioning

confidence: 99%

Chemometric-Assisted UV-Spectrophotometric Method for Quantification of Novel Anti-Tubercular Liquisolid Formulation

Tandel¹,

Patel²,

Thakkar³

et al. 2023

Int J Pharm Res Allied Sci

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To simultaneously determine quercetin and rifampicin in raw material and liquid-solid formulation, a numerical technique built on spectroscopic data associated with partial least squares (PLS) multi -variate measurement is suggested in this work. Rifampicin and quercetin spectra were captured at concentrations that fell within the 2-10 µg/ml linear range for each compound. They were used to compute 25 simulated mixtures containing 16 calibration and 9 validation sets, with wavelength spacing of λ=15 nm in hydrochloric acid (0.1 M) and phosphate buffer pH-6.8. The wavelength ranges were 200 to 630 nm. Based on the validation and calibration data's (RMSE) root mean square errors, the models' appropriateness was determined. Recovery studies (%) and relative prediction errors were used to compare and contrast the analytical capabilities of various chemometric techniques. The recovery study's findings showed that this technique was successfully used to formulate pharmaceuticals without excipient interference. The suggested technique is quick, easy to use, and can be utilised as a replacement for traditional analytical tools in the formulation and quality control of pharmaceuticals.

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“…Moreover, significant concerns with therapy are extensive treatment time, helpless patient consistency, impedance in a safe framework, and lung tissue demolition [3][4][5]. To beat the above issues, Quercetin as a natural bioenhancer was combined with a fixed dose combination of Rifampicin and Quercetin with the focus of improving bioavailability and decreasing the unfavorable impact related to the current tuberculosis treatment [6,7]. Quercetin, a pentahydroxy flavone is a flavonoid glycoside found in natural citrus products and is also used as a nutritional supplement.…”

Section: Introductionmentioning

confidence: 99%

“…It has antioxidant potential and is used for alleviating symptoms of heart disease, cancer, degenerative brain disorder, diabetes, and allergy. It shows hostility toward oxidants, extremist searching, and calming against atherosclerotic exercises [6,7].…”

Section: Introductionmentioning

confidence: 99%

Validated high‐performance thin layer chromatographic method for simultaneous quantification of rifampicin and quercetin in liquisolid formulation using fractional factorial design in robustness study

Tandel

Patel

Thakkar

2022

Separation Science Plus

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The present research study focuses on the development of the high‐performance thin‐layer chromatographic method using the design of experiment approach for the simultaneous estimation of Rifampicin and Quercetin. Chromatographic separation was performed on Aluminium plates precoated with silica gel 60 F254 using chloroform:methanol:formic acid:ethyl acetate:benzene (4:1.8:0.3:1.7:1, v/v/v/v/v) as optimized mobile phase. A fractional factorial design was applied for the robustness study and the independent variables selected were mobile phase composition (A), solvent front (B), chamber saturation time (C), and wavelength (D). It was statistically revealed that the volume of ethyl acetate affected the Rf of both drugs resulting in stricter control of ethyl acetate volume compared to the other three variables. Rf for Rifampicin and Quercetin was 0.35 and 0.71 at 347 nm. The linear concentration range was 100–600 ng/band for both drugs. The %recovery ranged between 95.25% and 96.71% for Rifampicin and 95.33%–96.86% for Quercetin. The method was validated by determination of linearity, precision, accuracy, and specificity according to Q2(R1) guidelines, and the %relative standard deviation values were less than 2% for both drugs. A simple, accurate, and reproducible high‐performance thin‐layer chromatographic method was developed, for routine quality control testing of pharmaceutical formulation.

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Chapter 10 Current trends on herbal bioenhancers

Cited by 3 publications

References 0 publications

Decoding the Postulated Entourage Effect of Medicinal Cannabis: What It Is and What It Isn’t

Decoding the Postulated Entourage Effect of Medicinal Cannabis: What It Is and What It Isn’t

Chemometric-Assisted UV-Spectrophotometric Method for Quantification of Novel Anti-Tubercular Liquisolid Formulation

Validated high‐performance thin layer chromatographic method for simultaneous quantification of rifampicin and quercetin in liquisolid formulation using fractional factorial design in robustness study

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