Chapitre V: proposer. Acheminement vers le parler

Lapidot, Elad

doi:10.7761/9789731997889_5

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“…The procedure for the synthesis and purification of NeoR6 [17], and for NeoR1, NeoR2, NeamR1, NeamR4, ParomR1 and ParomR5 was reported [25,26].…”

Section: Methodsmentioning

confidence: 99%

Structure–activity relationships of aminoglycoside‐arginine conjugates that bind HIV‐1 RNAs as determined by fluorescence and NMR spectroscopy

et al. 2004

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We present here a new set of aminoglycoside-arginine conjugates (AACs) that are either site-specific or per-arginine conjugates of paromomycin, neamine, and neomycin B as well as their structure-activity relationships. Their binding constants (K D ) for TAR and RRE RNAs, measured by fluorescence anisotropy, revealed dependence on the number and location of arginines in the different aminoglycoside conjugates. The binding affinity of the per-arginine aminoglycosides to TAR is higher than to RRE, and hexa-arginine neomycin B is the most potent binder (K D = 5 and 23 nM, respectively). The 2D TOCSY NMR spectrum of the TAR monoarginine-neomycin complex reveals binding at the bulge region of TAR.

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“…The procedure for the synthesis and purification of NeoR6 [17], and for NeoR1, NeoR2, NeamR1, NeamR4, ParomR1 and ParomR5 was reported [25,26].…”

Section: Methodsmentioning

confidence: 99%