Chaperonin-containing T-complex Protein 1 Subunit ζ Serves as an Autoantigen Recognized by Human Vδ2 γδ T Cells in Autoimmune Diseases

Chen, Hui; You, Hongqin; Wang, Lifang; Zhang, Xuan; Zhang, Jianmin; Wang, He

doi:10.1074/jbc.m115.700070

Cited by 10 publications

(9 citation statements)

References 31 publications

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“…Recently, it has been reported that γδT cells with NK cell–associated markers (including CD56 + T cells of the γδ type) are associated with renal fibrosis [63]. Our investigation showed that after stimulation with IL-2, IL-12, and IL-15, γδT cells, both with and without CD56 expression, exerted strong cytotoxicity against renal tubular epithelial cells, supporting a previous study [64] and further clarifying the pathogenesis of these cells.…”

Section: Cd56+ T Cells Act As Human Nkt Cells In Kidney Injurysupporting

confidence: 89%

Roles of Natural Killer T Cells and Natural Killer Cells in Kidney Injury

Uchida

Itô

Kumagai

et al. 2019

IJMS

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Mouse natural killer T (NKT) cells and natural killer (NK) cells are innate immune cells that are highly abundant in the liver. In addition to their already-known antitumor and antimicrobial functions, their pathophysiological roles in the kidney have recently become evident. Under normal circumstances, the proportion of activated NKT cells in the kidney increases with age. Administration of a synthetic sphingoglycolipid ligand (alpha-galactosylceramide) further activates NKT cells, resulting in injury to renal vascular endothelial cells via the perforin-mediated pathway and tubular epithelial cells via the TNF-α/Fas ligand pathway, causing acute kidney injury (AKI) with hematuria. Activation of NKT cells by common bacterial DNA (CpG-ODN) also causes AKI. In addition, NKT cells together with B cells play significant roles in experimental lupus nephritis in NZB/NZW F1 mice through their Th2 immune responses. Mouse NK cells are also assumed to be involved in various renal diseases, and there may be complementary roles shared between NKT and NK cells. Human CD56+ T cells, a functional counterpart of mouse NKT cells, also damage renal cells through a mechanism similar to that of mice. A subpopulation of human CD56+ NK cells also exert strong cytotoxicity against renal cells and contribute to the progression of renal fibrosis.

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Section: Cd56+ T Cells Act As Human Nkt Cells In Kidney Injurysupporting

confidence: 89%

Roles of Natural Killer T Cells and Natural Killer Cells in Kidney Injury

Uchida

Itô

Kumagai

et al. 2019

IJMS

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“…Tubulin was coded by TUBA1B (tubulin alpha 1b), the principal constituent of microtubules. Furthermore, CCT6A is associated with T cell reduction in cytotoxicity, immune function loss, and reduced T cell cytotoxicity during exhaustion with prolonged exposure to tumor antigens ( 28 ). In our Reaction pathway analysis, CCT6A played a role in forming tubulin folding intermediates via CCT/TriC formation of tubulin folding intermediates by CCT/TriC.…”

Section: Discussionmentioning

confidence: 99%

Dynamic Network Biomarker of Pre-Exhausted CD8+ T Cells Contributed to T Cell Exhaustion in Colorectal Cancer

Han

Zhong

et al. 2021

Front. Immunol.

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Immunotherapy has achieved positive clinical responses in various cancers. However, in advanced colorectal cancer (CRC), immunotherapy is challenging because of the deterioration of T-cell exhaustion, the mechanism of which is still unclear. In this study, we depicted CD8+ T-cell developmental trajectories and characterized the pre-exhausted T cells isolated from CRC patients in the scRNA-seq data set using a dynamic network biomarker (DNB). Moreover, CCT6A identified by DNB was a biomarker for pre-exhausted T-cell subpopulation in CRC. Besides, TUBA1B expression was triggered by CCT6A as DNB core genes contributing to CD8+ T cell exhaustion, indicating that core genes serve as biomarkers in pre-exhausted T cells. Remarkably, both TUBA1B and CCT6A expressions were significantly associated with the overall survival of COAD patients in the TCGA database (p = 0.0082 and p = 0.026, respectively). We also observed that cellular communication between terminally differentiated exhausted T cells and pre-exhausted T cells contributes to exhaustion. These findings provide new insights into the mechanism of T-cell exhaustion and provide clue for targeted immunotherapy in CRC.

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“…Our previous studies have demonstrated this hypothesis. [16][17][18][19] This study provides substantial evidence focus on TCR γδ repertoire to support this hypothesis.…”

Section: Discussionmentioning

confidence: 54%

Profiling the pattern of the human T-cell receptor γδ complementary determinant region 3 repertoire in patients with lung carcinoma via high-throughput sequencing analysis

et al. 2018

Self Cite

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γδ T cells function as sentinels in early host responses to infections and malignancies. Specifically, γδ T cells recognize tumor-associated stress antigens via T-cell receptor (TCR) γδ and play important roles in the antitumor immune response. In this study, we characterized the pattern of the human TCR γδ complementary determinant region 3 (CDR3) repertoire in patients with lung carcinoma (LC) via high-throughput sequencing. The results showed that the diversity of CDR3δ was significantly reduced, and that of CDR3γ was unchanged in LC patients compared with healthy individuals; in addition, LC patients shared significantly more CDR3δ sequences with each other than healthy individuals. The CDR3 length distribution and N-addition length distribution did not significantly differ between LC patients and healthy individuals. In addition, the CDR3 repertoire tended to use more Vδ2 and fewer Vδ1 germline gene fragments among LC patients. Moreover, we found a combination of four TCR γδ repertoire features that focus on CDR3δ and can be used as a biomarker for LC diagnosis. Our research suggests that the TCR γδ CDR3 repertoire changed in LC patients due to the antitumor immune response by γδ T cells in vivo, and these changes primarily focus on the amplification of certain tumor-specific CDR3δ clones among patients. This study demonstrates the role of γδ T cells from the TCR γδ CDR3 repertoire in tumor immunity and lays the foundation for elucidating the mechanism underlying the function of γδT cells in antitumor immunity.Cellular and Molecular Immunology advance online publication, 5 February 2018; doi:10.1038/cmi.2017.157.

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Chaperonin-containing T-complex Protein 1 Subunit ζ Serves as an Autoantigen Recognized by Human Vδ2 γδ T Cells in Autoimmune Diseases

Cited by 10 publications

References 31 publications

Roles of Natural Killer T Cells and Natural Killer Cells in Kidney Injury

Roles of Natural Killer T Cells and Natural Killer Cells in Kidney Injury

Dynamic Network Biomarker of Pre-Exhausted CD8+ T Cells Contributed to T Cell Exhaustion in Colorectal Cancer

Profiling the pattern of the human T-cell receptor γδ complementary determinant region 3 repertoire in patients with lung carcinoma via high-throughput sequencing analysis

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