Chaotic and periodic analysis of fetal magnetocardiogram recordings in growth restriction

Anastasiadis, P; Kotini, A; Anninos, P. A.; Adamopoulos, Adam; Sigalas, J; Koutlaki, N

doi:10.1002/pd.612

Cited by 14 publications

(16 citation statements)

References 31 publications

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“…In IUGR cases, both the difference in fetal size and other obstetric risks are higher, and the correlation dimension decreases when compared with the normal pregnancy group; that is, the heart rate coordination system is non-versatile and highly susceptible to stress. 27,28 In brief, it is critical to differentiate on grounds of perinatal management whether a fetus has low body weight alone, or whether it also has endogenous functional issues.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Fetal Autonomic Nervous System Activity by Fetal Magnetocardiography

Fukushima

Nakai

Itoh³

et al. 2008

Clinical medicine. Cardiology

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Aim: To clarify the signifi cance of heart rate variability for the evaluation of an autonomic nervous system (ANS) in the normal fetus using fetal magnetocardiography (FMCG).Methods: Subjects consisted of normal pregnancy (n = 35) at 28-39 weeks gestation. FMCG was recorded using 64-channel magnetocardiography (MCG) in a magnetically shielded room. The QRS interval was derived from signal-averaged MCG. The R-R interval variability induced by an R-wave trigger was eventually adopted to calculate for time-domain and frequency domain analysis. The power spectrum in the frequency domain was derived from frequency-fi eld components using the maximum entropy method of fetal heart rate variability. Based on frequency analysis, the ranges of the LF and HF domains were defi ned as 0.01-0.15 and 0.15-0.4 Hz, respectively. We defi ned a coeffi cient of variance (CV RR ) as an index of parasympathetic activity, and defi ned a low frequency/high frequency (LF/HF) ratio as a sympathetic activity. Results:The value of CV RR in the normal pregnancy group displayed a slight increasing trend with gestational age (y = 1.77 + 0.10x; r = 0.32). In contrast, the LF/HF ratio in the normal pregnancy group clearly increased over the gestational period (one-way ANOVA: P = 0.003). Conclusions:Analyses based on the time and frequency domains of heart rate variability using FMCG enable an evaluation of fetal ANS activity. Sympathetic nervous activity increased with gestational age in the normal pregnancy group.

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Section: Discussionmentioning

confidence: 99%

Assessment of Fetal Autonomic Nervous System Activity by Fetal Magnetocardiography

Fukushima

Nakai

Itoh³

et al. 2008

Clinical medicine. Cardiology

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“…For this review, a total of 16 studies were suitable for inclusion. Nine studies utilised NIFECG and 7 studies utilised magnetocardiography [15–30]. The characteristics of the studies and their findings have been illustrated in Tables 1 and 2 respectively.…”

Section: Resultsmentioning

confidence: 99%

A systematic review on the utility of non-invasive electrophysiological assessment in evaluating for intra uterine growth restriction

Smith

Nair

Warty

et al. 2019

BMC Pregnancy Childbirth

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Background Non-invasive electrophysiological assessment (NIEA) is an evolving area in fetal surveillance and is attracting increasing research interest. There is however, limited data outlining its utility in evaluating intra uterine growth restriction (IUGR). The objective of this study was to carry out a systematic review to outline the utility of NIEA parameters in evaluating IUGR. Methods A systematic review of peer reviewed literature was performed, searching PUBMED, Ovid MEDLINE and EMBASE. The outcomes of interest included NIEA parameters [P wave duration, PR interval, QRS duration, QT interval, T/QRS ratio, short term variability (STV) and long term variability (LTV)] and a descriptive summary of relevant studies as well. Results Sixteen studies were identified as suitable for inclusion. The utility of NIEA parameters were investigated in tabular form. In particular, QRS and QT duration, T/QRS ratio, STV and PRSA analysis displayed utility and merit further consideration in evaluating for IUGR. Issues identified in the review were in relation to variances in definition of IUGR, small sample sizes and the lack of technological consistency across studies. Conclusion NIEA shows promise as an adjunct surveillance tool in fetal diagnostics for IUGR. Larger prospective studies should be directed towards establishing reliable parameters with a focus on uniformity of IUGR definition, technological consistency and the individualisation of NIEA parameters. Electronic supplementary material The online version of this article (10.1186/s12884-019-2357-9) contains supplementary material, which is available to authorized users.

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“…MCG can thus be used for analysis of fetal heart rate variability, enabling further improvements to the accuracy of assessments of fetal wellbeing. Although analyses of heart rate variability have been attempted using FMCG, little has been established [20,21]. To advance the development of this method, we undertook the following studies: (1) elucidation of the developmental stages of fetal ANS over a period of 39 weeks; and (2) comparison of FMCG findings between normal pregnancy and FGR groups.…”

Section: Discussionmentioning

confidence: 99%

Prenatal Diagnosis of Fetal Arrhythmias and Assessment of Autonomic Nervous System Activity by Fetal Magnetocardiography

Fukushima

Matsumoto²,

Terata³

et al. 2012

TOMDJ

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Magnetocardiography (MCG) is a technique that enables the noncontact, noninvasive measurement of electrocardiographic phenomena, and fetal magnetocardiography (FMCG) is extremely useful for the analysis of fetal electrocardiographic phenomena. We have used FMCG for the diagnosis and treatment of a range of fetal arrhythmias, and to perform comparative studies of autonomic nervous system activity in fetuses with normal growth and those with fetal growth restriction by analyzing fetal heart rate variability. In terms of fetal arrhythmias, fatal long QT syndrome was accurately diagnosed prenatally using FMCG, and pregnancy was maintained until delivery at 37 weeks gestation. With regard to fetal autonomic nervous system activity, there was a pronounced increase in sympathetic nervous activity among fetuses with normal growth in the second half of pregnancy.

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Chaotic and periodic analysis of fetal magnetocardiogram recordings in growth restriction

Abstract: The analysis of FMCG recordings may offer important perspectives to understand significant features of the heart function of the fetuses. This technique improves the recognition of IUGR fetuses over healthy ones and may help improve perinatal morbidity and mortality.

Cited by 14 publications

References 31 publications

Assessment of Fetal Autonomic Nervous System Activity by Fetal Magnetocardiography

Assessment of Fetal Autonomic Nervous System Activity by Fetal Magnetocardiography

A systematic review on the utility of non-invasive electrophysiological assessment in evaluating for intra uterine growth restriction

Prenatal Diagnosis of Fetal Arrhythmias and Assessment of Autonomic Nervous System Activity by Fetal Magnetocardiography

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