2019
DOI: 10.1007/s10534-019-00176-6
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Channels, transporters and receptors for cadmium and cadmium complexes in eukaryotic cells: myths and facts

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Cited by 63 publications
(58 citation statements)
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“…Cadmium (Cd 2+ ) is a xenobiotic which is known to induce alteration of gene expression (Chen et al 2019;Rani et al 2014). Cd 2+ enters into the cells through numerous transporters including TRPM7 (Thevenod et al 2019). TRPM7 is for instance involved in Cd 2+ entry in HEK293 expressing TRPM7 (Monteilh-Zoller et al 2003) and in human osteoclasts (Martineau et al 2010).…”
Section: Discussionmentioning
confidence: 99%
“…Cadmium (Cd 2+ ) is a xenobiotic which is known to induce alteration of gene expression (Chen et al 2019;Rani et al 2014). Cd 2+ enters into the cells through numerous transporters including TRPM7 (Thevenod et al 2019). TRPM7 is for instance involved in Cd 2+ entry in HEK293 expressing TRPM7 (Monteilh-Zoller et al 2003) and in human osteoclasts (Martineau et al 2010).…”
Section: Discussionmentioning
confidence: 99%
“…In addition, Cd 2+ may bind to the amino acidcystine transporters (SLC79/SLC3A1 and SLC7A9/SLC7A13) to access the cytosol. Besides, it is accepted that Cd 2+ has direct interaction with cellular DNA, is capable of inhibiting the nuclease of incision during DNA repair, as well as be able to exert an interference in the chromatin condensation [36].…”
Section: Discussionmentioning
confidence: 99%
“…Cd in plasma is filterable by glomeruli if it is bound to GSH, amino acids, MT, or PC [8,9], but the fraction of circulating Cd that enters the filtrate is unknown. The proximal tubule reabsorbs and retains most or all of the filtered Cd with an array of channels, solute carriers, and mediators of endocytosis [7,10,[13][14][15][16]. Basolateral uptake may also add to the cellular content of Cd in the proximal tubule [16][17][18].…”
Section: Introductionmentioning
confidence: 99%