Channel catfish hepcidin expression in infection and anemia

Defensive response of European sea bass (Dicentrarchus labrax) against Listonella anguillarum or Photobacterium damselae subsp. piscicida experimental infection

“…In the present study, both infections induced a significant depression of the serum iron after 24 h and 72 h. Moreover, the hypoferremia was associated to the upregulation of the liver hepcidin in L. anguillarum-infected fish and this inverse correlation might be intended as a sea bass mechanism to reduce the iron availability for bacteria, as observed in other fish diseases (Hu et al, 2007). The hypoferremia and the hepcidin up-regulation were also detected after 24 h in Phdp-infected fish, but after 72 h the liver hepcidin returned to the control level, as reported in sea bream (Pellizzari et al, 2013), whereas the hypoferremia persisted.…”

Multiple Hepcidins in a Teleost Fish, Dicentrarchus labrax: Different Hepcidins for Different Roles

“…The decreased hepcidin levels would lead to decreased ferroportin degradation and increased iron release from hepatocytes, macrophages, and enterocytes (58)(59)(60), and increased iron uptake by the enterocytes mediated by slc11a2 (61)(62)(63)(64), to allow sufficient iron to reach the hematopoietic organs for an increased erythropoiesis, necessary to quickly replenish the lost RBCs and avoid possible damage caused by hypoxia. Studies on the impact of anemia on hepcidin expression in fish are scarce, with the exception of our own previous studies (28,34) and in Ictalurus punctatus (36). Never- FIGURE 6.…”

“…Other studies have examined the effects of iron overload in hepcidin (16-18, 21, 24, 28, 32), showing its involvement in the control of iron levels in fish. However, studies concerning other conditions known to affect hepcidin regulation, such as anemia (28,(34)(35)(36) or hypoxia (37), are scarce. Therefore, currently no comprehensive study addresses the functions of the two hepcidin types in a single fish species and gives equal attention to their role in both iron metabolism and immune response.…”

Molecular cloning and characterization of two novel hepcidins from orange-spotted grouper, Epinephelus coioides

“…Tissue-distribution studies revealed that hepcidin transcripts were widely expressed in multiple tissues, but the highest expression level was found predominantly in liver in mammals and in most fishes [14]. The gene expression of fish hepcidin was mostly associated with bacterial infection or inflammation, and only a few fish hepcidin genes were reported to be induced by iron overload [7,11,15].…”