Changing trends in antimicrobial susceptibility of Streptococcus pneumoniae isolates in Taiwan, 2006–2007

Li, Chien‐Feng; Liu, Meei Fang; Shi, Zhi Yuan; Hsueh, Po-Ren; Liao, Chun-Hsing; Jang, Tsrang Neng; Tsao, Shih Ming; Kung, Hsiang Chi; Hsu, Gwo-Jong; Lin, Hsiu Chen; Liu, Yung Ching; Chuang, Yin Ching; Wang, Lih Shinn; Chen, Chih‐Ming

doi:10.1016/j.jmii.2011.12.012

Cited by 11 publications

(16 citation statements)

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“…Cefotaxime and ceftriaxone have similar group of spectrum. The resistance rate to penicillin in the present study was higher than studies in Central Africa (< 6%) [8], Tunisia (1.2%) [13] and United States (14.8%) [9], but higher penicillin resistance rates were observed in Taiwan (43.3-73.2%) [14], Canada (26.1%) [15], China (88.3%) [16], Russia (28%) [17], Nigeria (28%) [18] and Guinea (21.5%) [19]. The high prevalence of penicillin resistance in this report reveals that the use of penicillin for empiric treatment of suspected pneumococcal infection should no longer be recommended.…”

Section: Discussioncontrasting

confidence: 78%

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Antimicrobial resistance profile and multidrug resistance patterns of Streptococcus pneumoniae isolates from patients suspected for pneumococcal infections in Ethiopia

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Moges

Yismaw

et al. 2020

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Backgrounds: Streptococcus pneumoniae is one of the leading causes of bacterial meningitis and pneumoniae in elderly people and children. Antimicrobial resistant strains of Streptococcus pneumoniae has been detected in all parts of the world and become one of the greatest challenges to global public health today. The aim of this study is therefore, to assess the antimicrobial resistance profiles and multidrug resistance patterns of S. pneumoniae isolates from patients suspected for pneumococcal infections in Ethiopia. Methods: A hospital-based prospective study was conducted from 2018 to 2019 at Addis Ababa and Amhara region referral hospitals. Antimicrobial resistance tests were performed on 57 isolates of S. pneumoniae that were collected from pediatric and adult patients. Samples (cerebrospinal fluid, blood, sputum, eye discharge, ear discharge, pleural and peritoneal fluids) from all collection sites were initially cultured onto 5 % sheep blood agar plates and incubated overnight at 370C in 5% CO2 atmosphere. S. pneumoniae was identified and confirmed by typical colony morphology, alpha-hemolysis, Gram staining, optochin susceptibility and bile solubility test. Drug resistance testing was performed using E-test method according to recommendations of the Clinical and Laboratory Standards Institute.Results: Of the 57 isolates, 17.5% were fully resistant to penicillin. Corresponding value for both cefotaxime and ceftriaxone was 1.8%. Resistance rates to erythromycin, clindamycin, tetracycline, chloramphenicol and trimethoprim-sulfamethoxazole were 59.6%, 17.5%, 38.6%, 17.5% and 24.6%, respectively. Multidrug resistance (MDR) was seen in 33.3% isolates. The most common pattern was co-resistance to penicillin, erythromycin, clindamycin and tetracycline.Conclusions: Most bacterial isolates were susceptible to Ceftriaxone and Cefotaxime. Penicillin has been used as a drug of choice for treating S. pneumoniae infection. However, antimicrobial resistance including multidrug resistance was observed to a number of commonly used antibiotics including penicillin. Hence, it is important to periodically monitor the antibiotic resistance patterns to choose empirical treatments for better management of pneumococcal infection.

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Section: Discussioncontrasting

confidence: 78%

“…The rate of resistance to erythromycin was 59.6%. This was lower than in studies done in Canada (100%) [15] and China (95.2%) [16], but higher than in Russia (26%) [17], Mozambique (23.6%) [20] and Pakistan (up to 29.7%) [21]. Seventeen and a half percent (17.5%) isolates were resistant to clindamycin.…”

Section: Discussioncontrasting

confidence: 56%

Antimicrobial resistance profile and multidrug resistance patterns of Streptococcus pneumoniae isolates from patients suspected for pneumococcal infections in Ethiopia

Sharew

Moges

Yismaw

et al. 2020

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“…In 2005, the World Health Organization (WHO) estimated that 0.7–1 million children, mostly from developing countries, died of pneumococcal disease annually [1]. The increasing trend of S.pneumoniae antimicrobial-resistance and emergence of multidrug- resistant (MDR) S.pneumoniae isolates, which may result from inappropriate use of antibiotics, has been a worldwide concern [2], [3], [4], [5]. The situation has been especially problematic in many Asian countries, China in particular.…”

Section: Introductionmentioning

confidence: 99%

Molecular Characterization and Antimicrobial Susceptibility of Streptococcus pneumoniae Isolated from Children Hospitalized with Respiratory Infections in Suzhou, China

et al. 2014

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BackgroundDissemination of antibiotic resistant clones is recognized as an important factor in the emergence and prevalence of resistance in pneumococcus. This study was undertaken to survey the antimicrobial susceptibility and serotypes distribution of pneumococci and to explore the circulating clones in hospitalized children in Suzhou, China.MethodsThe pneumococci were isolated from the nasopharyngeal aspirates of children less than 5 years of age admitted to Soochow-University-Affiliated-Children's-Hospital with respiratory infections. The capsular serotypes were identified by multiplex polymerase chain reaction (PCR). Antimicrobial susceptibility was tested by E-test. The presence of ermB, mefA/E genes were detected by PCR and the genotypes were explored by Multilocus sequence typing (MLST).ResultsFrom July 2012 to July 2013, a total of 175 pneumococcal isolates were collected and all strains were resistant to erythromycin and clindamycin, about 39.4% strains were non-susceptible to penicillin G. Overall, 174 (99.4%) isolates were resistant to ≥3 types of antibiotics. Serotypes 19F (28.1%), 6B (19.7%), 19A (18.0%), and 23F (17.4%) were the most common serotypes in all identified strains. The serotypes coverage of PCV7 and PCV13 were 71.9% and 89.9%, respectively. Four international antibiotic-resistant clones, including Taiwan19F-14 (n = 79), Spain23F-1(n = 25), Taiwan23F-15(n = 7) and Spain6B-2(n = 7), were identified. The Taiwan19F-14 clones have a higher non-susceptibility rate in β-lactams than other clones and non-clone isolates (p<0.001). In addition, 98.7% Taiwan19F-14 clones were positive of both ermB and mefA/E genes, compare to 33.3% in other clones and non-clone strains.ConclusionsThe spread of international antibiotic-resistant clones, especially Taiwan19F-14 clones, played a predominant role in the dissemination of antimicrobial resistant isolates in Suzhou, China. Considering the high prevalence of PCV7 serotypes and serotype 19A, the introduction of PCV13 may be a promising preventive strategy to control the increasing trend of clonal spread in China.

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“…Since 1965, many cases of infections due to drug-resistant S. pneumoniae have been reported [ 1 ]. The emergence of antimicrobial resistance is correlated with selective pressure from the use, often inappropriate, of antimicrobial agents and results in increased mortality, morbidity, and health care costs [ 2 ]. Antibacterial resistance in S. pneumoniae is increasing, affecting principally β-lactams and macrolides (azithromycin, erythromycin, or clarithromycin) with prevalence ranging between 1% and 90% depending on the geographical area [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Increase in the rate of azithromycin-resistant Streptococcus pneumoniae isolates carrying the erm(B) and mef(A) genes in Taiwan, 2006–2010

et al. 2014

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BackgroundThis study investigated the molecular characteristics of azithromycin-resistant Streptococcus pneumoniae in Taiwan.MethodsA total of 486 non-duplicate isolates of azithromycin-resistant S. pneumoniae recovered from various clinical sources of patients treated at 22 different hospitals in Taiwan from 2006 to 2010. The presence of erm(B) and mef(A) genes using duplex PCR, multilocus sequence typing (MLST), and pulsed-field gel electrophoresis of these isolates were studied.ResultsOf the isolates tested, 59% carried the erm(B) gene, 22% carried the mef(A) gene, and 19% carried both genes. The prevalence of isolates carrying the erm(B) and mef(A) genes increased from 10% (11/110) in 2006 to 25% (15/60) in 2010 (p-value = 0.0136). The majority of isolates carrying both erm(B) and mef(A) genes belonged to serotypes 19 F (64%) followed by 19 F A (24%). Of these isolates, 33% were sequence type 320 (ST320), 32% were ST236, and 12% were ST271.ConclusionsThe increase in incidence of mef(A)/erm(B)-positive azithromycin-resistant S. pneumoniae isolates during the study period was primarily due to serotypes 19 F and 19A and ST236 and ST320.Electronic supplementary materialThe online version of this article (doi:10.1186/s12879-014-0704-z) contains supplementary material, which is available to authorized users.

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Changing trends in antimicrobial susceptibility of Streptococcus pneumoniae isolates in Taiwan, 2006–2007

Cited by 11 publications

References 23 publications

Antimicrobial resistance profile and multidrug resistance patterns of Streptococcus pneumoniae isolates from patients suspected for pneumococcal infections in Ethiopia

Antimicrobial resistance profile and multidrug resistance patterns of Streptococcus pneumoniae isolates from patients suspected for pneumococcal infections in Ethiopia

Molecular Characterization and Antimicrobial Susceptibility of Streptococcus pneumoniae Isolated from Children Hospitalized with Respiratory Infections in Suzhou, China

Increase in the rate of azithromycin-resistant Streptococcus pneumoniae isolates carrying the erm(B) and mef(A) genes in Taiwan, 2006–2010

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