Changing trends in antimicrobial susceptibility pattern of bacterial isolates in a burn unit

Singh, Narendra; Rani, Mayuri; Gupta, Kanupriya; Sagar, Tanu

doi:10.1016/j.burns.2017.01.016

Cited by 40 publications

(36 citation statements)

References 16 publications

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“…aureus (12%) has been reported in other studies [1,5]; the prevalence of P. aeruginosa in the present study was comparable to that in the previous report [5]. Moreover, S. aureus (25%) followed by P.…”

Section: Discussionsupporting

confidence: 88%

“…However, other Gram negative isolates like Acinetobacter may also be found in burn wounds [1,5,29]. In the present study, E. coli (28.4%) was the most prevalent bacterial species as similar to other reports [13] followed by P. aeruginosa (22.2%), S. aureus (19.6%), K. pneumoniae (16.4%), and coagulase-negative staphylococci (13.3%) ( Tables 1 and 2).…”

Section: Discussionsupporting

confidence: 87%

“…Gram negative organisms have been recognized as dominant pathogen in burn patients [18,[26][27][28] and among these, the most frequent species were Klebsiella, E. coli, Pseudomonas and Proteus [1,4,10].…”

Section: Discussionmentioning

confidence: 99%

“…Septic processes account for 73% of death within the initial five days of post-burn [1][2][3][4][5]. Furthermore, exudate around burn wound is highly nutritive for growth and proliferation of microorganism [1,6].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, exudate around burn wound is highly nutritive for growth and proliferation of microorganism [1,6]. Skin is regarded as the first line defense against pathogens exposure; however, any thermal injury results in physical barrier disruption leading to pathogen invasion.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Antimicrobial susceptibility patterns and CTX-M β-lactamase producing clinical isolates from burn patients in Islamabad, Pakistan

Hussain¹,

Munir²,

Fatima³

et al. 2017

APJTD

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Antimicrobial susceptibility patterns and CTX-M β-lactamase producing clinical isolates from burn patients in Islamabad, Pakistan

Hussain¹,

Munir²,

Fatima³

et al. 2017

APJTD

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Basic research and clinical exploration of cold atmospheric plasma for skin wounds

Gao

Wang

et al. 2023

Bioengineering & Transla Med

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Skin wounds, such as burns, diabetic foot ulcers, pressure sores, and wounds formed after laser or surgical treatment, comprise a very high proportion of dermatological disorders. Wounds are treated in a variety of ways; however, some wounds are greatly resistant, resulting in delayed healing and an urgent need to introduce new alternatives. Our previous studies have shown that cold atmospheric plasma (CAP) has antibacterial activity and promotes cell proliferation, differentiation, and migration in vitro. To further advance the role of CAP in wound healing, we evaluated the safety and efficacy of CAP in vitro by irradiation of common refractory bacteria on the skin, irradiation of normal skin of rats and observing reactions, treatment of scald wounds in rats, and treating clinically common acute wounds. Our findings revealed that CAP can eliminate refractory skin bacteria in vitro; CAP positively affected wound healing in a rat scalding wound model; and direct CAP irradiation of low intensity and short duration did not lead to skin erythema or edema. CAP promises to be a new, economical, and safe means of wound treatment.

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The effects of major burn related pathophysiological changes on the pharmacokinetics and pharmacodynamics of drug use: An appraisal utilizing antibiotics

Udy

Roberts

Lipman

et al. 2018

Advanced Drug Delivery Reviews

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Patients suffering major burn injury represent a unique population of critically ill patients. Widespread skin and tissue damage causes release of systemic inflammatory mediators that promote endothelial leak, extravascular fluid shifts, and cardiovascular derangement. This phase is characterized by relative intra-vascular hypovolaemia and poor peripheral perfusion. Large volume intravenous fluid resuscitation is generally required. The patients' clinical course is then typically complicated by ongoing inflammation, protein catabolism, and marked haemodynamic perturbation. At all times, drug distribution, metabolism, and elimination are grossly distorted. For hydrophilic agents, changes in volume of distribution and clearance are marked, resulting in potentially sub-optimal drug exposure. In the case of antibiotics, this may then promote treatment failure, or the development of bacterial drug resistance. As such, empirical dose selection and pharmaceutical development must consider these features, with the application of strategies that attempt to counter the unique pharmacokinetic changes encountered in this setting.

show abstract

Changing trends in antimicrobial susceptibility pattern of bacterial isolates in a burn unit

Cited by 40 publications

References 16 publications

Antimicrobial susceptibility patterns and CTX-M β-lactamase producing clinical isolates from burn patients in Islamabad, Pakistan

Antimicrobial susceptibility patterns and CTX-M β-lactamase producing clinical isolates from burn patients in Islamabad, Pakistan

Basic research and clinical exploration of cold atmospheric plasma for skin wounds

The effects of major burn related pathophysiological changes on the pharmacokinetics and pharmacodynamics of drug use: An appraisal utilizing antibiotics

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