Changing trends and influencing factors of the quality of life of chemotherapy patients with breast cancer

Ai, Zhongping; Gao, Xiaolan; Li, Jinfeng; Zhou, Jian; Wu, Youfeng

doi:10.25164/cnr201701005

Cited by 7 publications

(9 citation statements)

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“…This finding is consistent with previous studies that found that patients who received multiple types of CTX reported more treatment-related adverse effects, which can negatively impact their QOL [29,30]. In addition, and consistent with our findings regarding length of time from cancer diagnosis, patients are more likely to receive additional treatments as a result of disease progression which could result in cumulative toxicities [31].…”

Section: Discussionsupporting

confidence: 93%

“…Descriptive statistics as means and standard deviations (SD) for quantitative variables and frequencies and percentages for categorical variables were calculated. Based on a review of the literature of characteristics that are known to influence the QOL of patients with cancer, treatment group (i.e., CTX alone or in combination with TT) [22,23], age [24,25], number of metastatic sites [26], time from cancer diagnosis [27,28], number of prior cancer treatments [29,30], GI cancer diagnosis [17], CTX regimen [31] were evaluated as covariates in our longitudinal analyses.…”

Section: Methodsmentioning

confidence: 99%

“…Given these inconsistent findings, the purpose of this study was to evaluate for changes in QOL scores in a sample of patients with GI cancers who were assessed six times over two cycles of CTX using a disease specific and a generic measure of QOL. In addition, the effect of select demographic and clinical characteristics that are known to influence cancer patients’ QOL (i.e., treatment group [CTX alone or in combination with TT] [22,23], age [24,25], number of metastatic sites [26], time from cancer diagnosis [27,28], number of prior cancer treatments [29,30], GI cancer diagnosis[i.e., colon/rectum/anal versus pancreatic/liver, gall bladder/esophageal/small intestine] [17], CTX regimen [31]) on patients’ enrollment scores, as well as on changes in QOL scores were evaluated. We hypothesized that QOL scores would change over time and that each of these covariates would influence patients’ enrollment, as well as the trajectories of each of the QOL outcomes that were evaluated in this study.…”

Section: Introductionmentioning

confidence: 99%

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Quality of life of patients with gastrointestinal cancers undergoing chemotherapy

et al. 2018

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Section: Discussionsupporting

confidence: 93%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Quality of life of patients with gastrointestinal cancers undergoing chemotherapy

et al. 2018

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“…Esse tratamento consiste na administração de substâncias citotóxicas, principalmente por via sistêmica. Pacientes submetidos a esse tratamento podem apresentar efeitos colaterais como náuseas, vômitos, alterações de massa corporal e ansiedade, levando a mudanças na qualidade de vida 2,3 .…”

Section: Introductionunclassified

Análise correlacional durante e após os ciclos de quimioterapia com o perfil de ansiedade de pessoas com câncer

et al. 2017

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Introdução: O sofrimento emocional vivenciado pelos pacientes com câncer, somado aos pensamentos negativos, favorece o aparecimento da ansiedade e da depressão. Objetivo: Correlacionar a ansiedade relatada com os dados sociodemográficos, antropométricos e clínicos de pacientes com câncer durante e após a quimioterapia. Métodos: Foram avaliados 38 voluntários que realizavam quimioterapia (GQ) (idade: 58,24±14,19), e nove voluntários que já finalizaram o tratamento (GC) (idade: 59,78±18,23). Para todos os voluntários, foi utilizado o Inventário de Ansiedade Traço-Estado (IDATE) para mensurar o perfil de ansiedade. Resultados: Para a massa corpórea e IMC do GQ, foi observado um índice de correlação de Spearman r= -0,590 (p<0,001) e r=-0,477 (p=0,002), respectivamente. Para o GC, as mesmas variáveis apresentaram um índice de correlação de Spearman de r= 0,786 (p=0,036) e r= 0,683 (p=0,042), respectivamente. Conclusão: Ambos os grupos apresentaram correlações significativas do nível de ansiedade para as variáveis clínicas, porém o GC apresentou maior correlação do nível de ansiedade com essas variáveis em comparação ao GQ.

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“…Finally, unaddressed physical symptoms and psychosocial challenges may lead to patients' compromised wellbeing such as decreased self-efficacy, increased risk of substance use, and reduced quality of life. For example, studies have found that breast cancer patients' quality of life was the lowest before postoperative chemotherapy, increased after the second chemotherapy, then lowered again after the fourth and fifth rounds of chemotherapy [18]. The quality of life trajectory among breast cancer patients continues to fluctuate throughout their post-treatment survivorship care, highlighting the needs for ongoing surveillance and interventions to address breast cancer patients' biopsychosocial challenges [19].…”

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confidence: 99%

Mindfulness-based interventions for breast cancer patients in China across outcome domains: a systematic review and meta-analysis of the Chinese literature

Shi-jie

Zhang

Chen

et al. 2021

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Objective This study aims to evaluate the treatment effect of a mindfulness-based intervention for Chinese breast cancer patients across outcome domains, including symptom-related, psychosocial, and quality of life outcomes. Methods Following the Cochrane Systematic Review guideline, we searched across five electronic databases, reference lists of eligible studies, professional websites, and major academic journals in Chinese. Publication bias was assessed using funnel plot and Vevea and Woods sensitivity analysis, and risk of bias was evaluated using the revised Cochrane risk of bias tool for randomized trials and risk of bias in non-randomized studies of interventions. A meta-analysis of Hedges' g was conducted using meta-regression with robust variance estimation. Results Final analysis included a total of 45 controlled trials containing 286 effect size estimates. Across outcome domains, studies reported an overall large and statistically significant treatment effect, d = 0.921, 95% CI (0.805, 1.040), p < 0.001. Subgroup analyses of specific domains of outcome reported overall significant treatment effects for (1) symptom-related outcomes, d = 0.885, 95% CI (0.657, 1.110), p < 0.001; (2) psychosocial wellness outcomes, d = 0.984, 95% CI (0.879, 1.090), p < 0.001; and (3) quality of life, d = 0.990, 95% CI (0.776, 1.200), p < 0.001. Moderator analysis did not identify any significant moderator. Conclusion Chinese literature reported an overall statistically significant and large treatment effect of a mindfulness-based intervention for breast cancer patients in China. Except for physical symptom outcomes, e.g., nausea/vomiting and pain, a mindfulness-based intervention was effective across outcome domains among Chinese breast cancer patients. Keywords Breast cancer . Mindfulness-based intervention . Systematic review and meta-analysis Breast cancer is the most common cancer and cause of cancerrelated death among women internationally [1]. There were over 2 million newly diagnosed breast cancer patients worldwide in 2018, including 626,679 associated deaths [2].

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Changing trends and influencing factors of the quality of life of chemotherapy patients with breast cancer

Cited by 7 publications

References 0 publications

Quality of life of patients with gastrointestinal cancers undergoing chemotherapy

Quality of life of patients with gastrointestinal cancers undergoing chemotherapy

Análise correlacional durante e após os ciclos de quimioterapia com o perfil de ansiedade de pessoas com câncer

Mindfulness-based interventions for breast cancer patients in China across outcome domains: a systematic review and meta-analysis of the Chinese literature

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