Changing the Metabolic Profile by Large-Volume Liposuction: A Clinical Study Conducted with 123 Obese Women

Abstract

Adipose tissue is a metabolically active tissue. The hypertrophic fat cells of obese patients produce increased quantities of leptin and tumor necrosis factor-alpha (TNF-alpha) and are less sensitive to insulin. This study aimed to determine whether aspirating large amounts of these subcutaneous fat cells by large-volume liposuction (LVL), could change the metabolic profile in 123 obese women. All the patients had a main central body fat distribution (waist-hip ratio, 0.91+/-0.01) and a body mass index of 32.8 +/- 0.8 kg/m). They were studied for 90 days after LVL to determine their changes in insulin sensitivity, resting metabolic rate, serum adipocytokines, and inflammatory marker levels. During 3 months of follow-up evaluation, LVL resulted in a significantly improved insulin sensitivity, resting metabolic rate, serum adipocytokines, and inflammatory marker levels. Such parameters correlate with a decrease in fat mass and waist-hip ratio. Interestingly, no significant changes were seen between the first (21 days) and second (90 days) metabolic determinations after LVL. However, these findings, confirm other preliminary data published previously, and could change the actual role of LVL in the multidisciplinary treatment of obesity.

Lower body adipose tissue removal decreases glucose tolerance and insulin sensitivity in mice with exposure to high fat diet

“…We, therefore, performed 2 secondary studies to determine whether IngX-induced metabolic impairments were sustained following an extended experimental duration, 13 weeks, or was exacerbated in mice with existing glucose intolerance. While pronounced short-term metabolic improvements have been demonstrated with LBSAT removal, 61 many have demonstrated that large volume removal of LBSAT in obese humans results in minimal metabolic improvement, with short term decreases in circulating lipids and fasting insulin, 17,[19][20][21]62 but no long-term differences. 16 In the present study IngX-induced metabolic effects were sustained, yet to some extent attenuated, in both Chow and HFD mice after a longer experiment duration.…”

Relationships between adipose tissue and cytokine responses to a randomized controlled exercise training intervention

“…In the context of loss of fat mass induced via liposuction, such investigations have produced conflicting reports of alterations, or a lack thereof, in systemic concentrations of inflammatory markers [7,8]. In addition, both diet-induced weight loss [9] as well as combined caloric restriction and exercise interventions [10] appear to reduce concentrations of several inflammatory markers.…”

C-Reactive Protein Decrease After Postbariatric Abdominoplasty

“…Otherwise, a stable nutritional biochemical pattern was documented throughout the observation period (Table 2). Table 3 summarizes the findings from the literature concerning the impact of liposuction and abdominoplasty on metabolic variables [2][3][4][5][6][7][8][9][10][11][12].…”

“…Alleviation of systemic inflammation and insulin resistance has been reported by some researches, whereas in certain studies, the improvement of plasma lipids has been confirmed [4][5][6][7][8]. In contrast, no changes in insulin action and cardiovascular risk factors have been noticed by other studies [9,10].…”