Changing the Blood Test: Accurate Determination of Mercury(II) in One Microliter of Blood Using Oriented ZnO Nanobelt Array Film Solution‐Gated Transistor Chips

Li, Yi‐Xiang; Yang, Meng; Li, Pei‐Hua; Chen, Shi‐Hua; Li, Yongyu; Guo, Zheng; Li, Shanshan; Jiang, Min; Lin, Chin E.; Huang, Xing‐Jiu

doi:10.1002/smll.201902433

Cited by 10 publications

(4 citation statements)

References 72 publications

(64 reference statements)

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“…10B). 184 As shown in Fig. 10B, the solution-gated field-effect transistor devices with ZnO nanoribbon arrays between the interdigital electrodes were constructed and further modified with anchored probe molecules (-SH).…”

Section: Electrical Applicationsmentioning

confidence: 99%

Controllable-assembled functional monolayers by the Langmuir–Blodgett technique for optoelectronic applications

Lin,

Zheng,

Zhong

et al. 2024

J. Mater. Chem. C

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Section: Electrical Applicationsmentioning

confidence: 99%

Controllable-assembled functional monolayers by the Langmuir–Blodgett technique for optoelectronic applications

Lin,

Zheng,

Zhong

et al. 2024

J. Mater. Chem. C

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“…A field-effect transistor (FET) is a voltage-controlled three-terminal device consisting of source, drain, and gate terminals. FET-based sensors have been used to detect biological and chemical molecules, such as glucose, DNA, protein, Pb 2+ , , and Hg 2+ − due to their rapid response time, high sensitivity, easy operation, and portable platform. , At present, some conductive two-dimensional materials, that is, graphene and molybdenum disulfide (MoS 2 ), have been used as alternative materials for sensitive detection of biological and chemical molecules owing to their high specific surface area and more active adsorption sites. − For example, Chen reported a FET sensor based on thermally reduced graphene oxide channel materials for mercury detection in aqueous solutions, and the detection of limit was 0.25 nM. Jang adopted a liquid-gated FET-type flexible graphene sensor to realize Hg 2+ detection, with a detection limit of 10 pM in PBS solution and a real environment.…”

Section: Introductionmentioning

confidence: 99%

“…Chen fabricated a DNA-modified MoS 2 nanosheet/Au nanoparticle FET sensor and can detect Hg 2+ at a low concentration of 0.1 nM. Besides, other materials such as ZnO nanobelts and covalent organic frameworks are also involved in the detection of Hg 2+ . Abovementioned results reveal that the structure of materials has a great influence on their detection activity, and there is little work concerning the tunable sensing activity.…”

Section: Introductionmentioning

confidence: 99%

Adjustable Synthesis of Ni-Based Metal–Organic Framework Membranes and Their Field-Effect Transistor Sensors for Mercury Detection

Shen

Tan

Tang

et al. 2022

ACS Appl. Electron. Mater.

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Due to high toxicity of mercury ions (Hg2+), many efforts have been devoted to realize the detection of Hg2+ with low concentration, in which to establish the relationship among the structure, electricity property, and detection activity of sensing materials is of prime importance. In this work, a field-effect transistor (FET) sensor based on a conductive Ni3(HITP)2 membrane was employed to realize Hg2+ detection. Such a Ni3(HITP)2 membrane was synthesized in situ by a one-step hydrothermal method, and the influence of the volume ratio of ammonia to water on its structure and Hg2+ detection performance was systematically investigated. It is found that with increasing the volume ratio of ammonia to water, the Ni3(HITP)2 membrane composed of flake-shaped structure becomes denser, its thickness increases from 24.1 to 114.7 nm, and the mobility of the Ni3(HITP)2 FETs increases nearly 2 orders of magnitudes. For Hg2+ detection, the Ni3(HITP)2 membrane is modified with a glutaraldehyde (GA) cross-linking agent and DNA probes. The optimized Ni3(HITP)2-GA-DNA FET-based sensor can detect Hg2+ with high specificity in a concentration range of 10 pM–100 nM. The excellent detection performance is attributed to the close contact between the Ni3(HITP)2 membrane and Si/SiO2 substrate, large surface area of the membrane, and specific bonding of Hg2+ with DNA probes modified on the membrane surface. This work will have a great significance for the application of metal–organic frameworks in electronic devices and ion detection.

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“…However, nanometer-scaled ZnO particles could have different crystalline structures and different physical and chemical properties from bulk materials , because of the small size effect. In particular, one-dimensional (1D) ZnO nanomaterials, such as nanowires, nanorods, nanofibers, nanobelts, and nanotubes, are expected to have unique applications and have had broad interest because of their intrinsic anisotropic nature. However, it is essential to clarify the formation mechanism of 1D ZnO nanomaterials in order to control precisely the synthesis of 1D ZnO nanomaterials.…”

Section: Introductionmentioning

confidence: 99%

Hydrothermal Synthesis and Structures of Unknown Intermediate Phase Zn(HCO₃)₂·H₂O Nanoflakes and Final ZnO Nanorods

et al. 2022

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The formation mechanism of nanoparticles is of great significance for the controllable synthesis, structural design, and performance optimization of nanomaterials. In this paper, an economical hydrothermal method was used to synthesize zinc oxide (ZnO) nanorods. X-ray diffraction, X-ray absorption fine structure, and small-angle X-ray scattering techniques were used to probe the structural changes. Scanning electron microscopy and high-resolution transmission electron microscopy were used to observe the morphologies of the products. A self-designed in situ temperature–pressure sample cell was used to control the hydrothermal conditions. The results demonstrate that an unknown intermediate phase, Zn(HCO3)2·H2O, was first formed at 50 °C, having a morphology of nanoflakes with a average thickness of about 35 nm. The intermediate phase Zn(HCO3)2·H2O was determined to have a monoclinic structure with space group P1211 and the following lattice parameters: a = 11.567 Å, b = 3.410 Å, c = 5.358 Å, β = 96.0011°, and Z = 2. After a hydrothermal temperature of 140 °C, CO2 and H2O were evaporated from the Zn(HCO3)2·H2O intermediate product and the ZnO nanorods with a wurtzite structure were formed. The final ZnO nanorods have an average diameter of about 45 nm and an average length of about 2 μm. The axial direction of the ZnO nanorods is the [001] crystallographic direction. By virtue of understanding the formation mechanism, this work is helpful for the controllable synthesis of ZnO nanoparticles.

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Changing the Blood Test: Accurate Determination of Mercury(II) in One Microliter of Blood Using Oriented ZnO Nanobelt Array Film Solution‐Gated Transistor Chips

Abstract: The authors declare no conflict of interest. Keywords2D material (nanobelt), assembled oriented films, blood mercury ion, sensing mechanism, solution-gated field-effect transistor (FET)

Cited by 10 publications

References 72 publications

Controllable-assembled functional monolayers by the Langmuir–Blodgett technique for optoelectronic applications

Controllable-assembled functional monolayers by the Langmuir–Blodgett technique for optoelectronic applications

Adjustable Synthesis of Ni-Based Metal–Organic Framework Membranes and Their Field-Effect Transistor Sensors for Mercury Detection

Hydrothermal Synthesis and Structures of Unknown Intermediate Phase Zn(HCO₃)₂·H₂O Nanoflakes and Final ZnO Nanorods

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Changing the Blood Test: Accurate Determination of Mercury(II) in One Microliter of Blood Using Oriented ZnO Nanobelt Array Film Solution‐Gated Transistor Chips

Abstract: The authors declare no conflict of interest. Keywords2D material (nanobelt), assembled oriented films, blood mercury ion, sensing mechanism, solution-gated field-effect transistor (FET)

Cited by 10 publications

References 72 publications

Controllable-assembled functional monolayers by the Langmuir–Blodgett technique for optoelectronic applications

Controllable-assembled functional monolayers by the Langmuir–Blodgett technique for optoelectronic applications

Adjustable Synthesis of Ni-Based Metal–Organic Framework Membranes and Their Field-Effect Transistor Sensors for Mercury Detection

Hydrothermal Synthesis and Structures of Unknown Intermediate Phase Zn(HCO3)2·H2O Nanoflakes and Final ZnO Nanorods

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Hydrothermal Synthesis and Structures of Unknown Intermediate Phase Zn(HCO₃)₂·H₂O Nanoflakes and Final ZnO Nanorods