Changing Profile of Infective Endocarditis&lt;SUBTITLE&gt;Results of a 1-Year Survey in France&lt;/SUBTITLE&gt;

Hoën, Bruno; Alla, François; Selton-Suty, Christine; Béguinot, I.; Bouvet, Anne; Briançon, Serge; Casalta, Jean‐Paul; Danchin, Nicolás; Delahaye, François; Etienne, Jérôme; Moing, Vincent Le; Leport, Catherine; Mainardi, Jean–Luc; Ruimy, Raymond; Vandenesch, François

doi:10.1001/jama.288.1.75

Cited by 864 publications

(378 citation statements)

References 20 publications

Supporting

Mentioning

300

Contrasting

Unclassified

Order By: Relevance

“…The NVS have been implicated in cases of bacteremia/septicemia and account for an estimated 4 to 8% of all cases of infective endocarditis (IE) due to viridans group streptococcus-like organisms (8)(9)(10)(11). The NVS have also been associated with other invasive infections, including abscess, wound infections, and meningitis (1,12).…”

Section: T He Nutritionally Variant Streptococci (Nvs) Are Fastidiousmentioning

confidence: 99%

Antimicrobial Susceptibilities of Abiotrophia defectiva, Granulicatella adiacens, and Granulicatella elegans

Alberti

Hindler

Humphries

2016

Antimicrob Agents Chemother

View full text Add to dashboard Cite

Nutritionally variant streptococci (NVS) are fastidious Gram-positive cocci comprised of the species Abiotrophia defectiva, Granulicatella adiacens, and Granulicatella elegans. NVS are an important cause of bacteremia and infective endocarditis (IE) associated with significant morbidity and mortality. Antimicrobial susceptibility testing (AST) was performed for 14 antimicrobials using the broth microdilution MIC method described in the Clinical and Laboratory Standards Institute (CLSI) M45 guideline. A total of 132 clinical NVS blood isolates collected from 2008 to 2014 were tested. Species level identification of NVS isolates was achieved by 16S rRNA gene sequencing and/or matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). Ninety isolates were identified as G. adiacens, 37 as A. defectiva, and 5 as G. elegans. All isolates were susceptible to vancomycin (MIC 90 ‫؍‬ 1 g/ml), and none displayed high-level resistance to aminoglycosides. G. adiacens was considerably more susceptible to penicillin than A. defectiva (38.9% versus 10.8% of isolates susceptible) but was less susceptible to cephalosporins than was A. defectiva (43.3% versus 100% of isolates susceptible to ceftriaxone). Several isolates were resistant to levofloxacin (6%), erythromycin (51%), and clindamycin (10%). The MIC 90 for daptomycin was >4 g/ml for G. adiacens and A. defectiva. G. elegans isolates were 100% susceptible to all antimicrobials tested, with the exception of erythromycin, to which only 20% were susceptible. This study provides antimicrobial susceptibility data for a recent collection of NVS and demonstrates important NVS species-related differences with respect to susceptibility to penicillin, cephalosporins, carbapenems, and daptomycin. Species-level identification of NVS organisms when susceptibility testing is not readily available may aid in treatment decisions.

show abstract

Section: T He Nutritionally Variant Streptococci (Nvs) Are Fastidiousmentioning

confidence: 99%

Antimicrobial Susceptibilities of Abiotrophia defectiva, Granulicatella adiacens, and Granulicatella elegans

Alberti

Hindler

Humphries

2016

Antimicrob Agents Chemother

View full text Add to dashboard Cite

show abstract

“…Despite improvements in diagnosis, therapeutics, and surgical treatments, there has been no substantive improvement in the survival rate of IE patients over the last 30 years (1)(2)(3)(4). Vegetative growths on the endocardium that contain bacteria and host factors lead to the clinical effects of IE, including valvular incompetence and congestive heart failure.…”

mentioning

confidence: 99%

Streptococcus oralis Neuraminidase Modulates Adherence to Multiple Carbohydrates on Platelets

et al. 2017

View full text Add to dashboard Cite

Adherence to host surfaces is often mediated by bacterial binding to surface carbohydrates. Although it is widely appreciated that some bacterial species express glycosidases, previous studies have not considered whether bacteria bind to multiple carbohydrates within host glycans as they are modified by bacterial glycosidases. Streptococcus oralis is a leading cause of subacute infective endocarditis. Binding to platelets is a critical step in disease; however, the mechanisms utilized by S. oralis remain largely undefined. Studies revealed that S. oralis, like Streptococcus gordonii and Streptococcus sanguinis, binds platelets via terminal sialic acid. However, unlike those organisms, S. oralis produces a neuraminidase, NanA, which cleaves terminal sialic acid. Further studies revealed that following NanA-dependent removal of terminal sialic acid, S. oralis bound exposed ␤-1,4-linked galactose. Adherence to both these carbohydrates required Fap1, the S. oralis member of the serine-rich repeat protein (SRRP) family of adhesins. Mutation of a conserved residue required for sialic acid binding by other SRRPs significantly reduced platelet binding, supporting the hypothesis that Fap1 binds this carbohydrate. The mechanism by which Fap1 contributes to ␤-1,4-linked galactose binding remains to be defined; however, binding may occur via additional domains of unknown function within the nonrepeat region, one of which shares some similarity with a carbohydrate binding module. This study is the first demonstration that an SRRP is required to bind ␤-1,4-linked galactose and the first time that one of these adhesins has been shown to be required for binding of multiple glycan receptors.

show abstract

“…Although 20 to 30% of patients with infective endocarditis have no predisposing risk factors [1,2], this case involved rare clinical and anatomical abnormalities occurring simultaneously: ASA with PFO and right-sided infective endocarditis. The prevalence in the general population of ASA is 2-4%, and when associated with a PFO, it is up to 70% [3].…”

Section: Discussionmentioning

confidence: 89%

Dual-sided Infective Endocarditis due to Atrial Septal Aneurysm With Patent Foramen Ovale

Kondō¹,

Machizuka²,

Hirata³

et al. 2005

J Echocardiogr

View full text Add to dashboard Cite

Right-sided infective endocarditis is generally known to occur in drug abusers and in patients with long indwelling venous catheters. Paradoxical cerebral embolization is a rare condition causing cerebrovascular accident. This patient had neither apparent drug history nor predisposing factors to infective endocarditis and systemic thromboembolism. It was a very rare case that was complicated not only by both-sided infective endocarditis but also by paradoxical embolism through a patent foramen ovale (PFO). CaseA 36-year-old female was admitted to our hospital for evaluation of 5 days of high fever of unknown origin and abrupt abnormal behavioral change associated with mental disturbance. Her vital signs were as follows: body temperature, 39.7 ; blood pressure, 120/80 mmHg; pulse, 140 bpm. On physical examination, the patient was drowsy and disoriented. Cardiac auscultation revealed a grade II pan-systolic murmur at the right sternal border. There were no prominent peripheral signs or neurological deficits. The chest Xray showed mild cardiomegaly and pulmonary artery dilation but she had no symptoms of heart failure. An abdominal CT showed a right iliopsoas abscess; a head CT showed a hematoma at the right frontal lobe, and edema of the brain stem and right occipital lobe. Transthoracic echocardiography (TTE) and transesophageal echocardiography (TEE) disclosed a huge vegetation of the tricuspid valve and an atrial septal aneurysm (ASA) with PFO that had a right to left shunt confirmed by intravenous bubble injection (Figure 1, 2). The mitral and aortic valve was not affected, and during color Doppler examination, no abnormal flow was detected. Additionally, methicillinsensitive Staphylococcus aureus was detected by blood culture. We diagnosed right-sided infective endocarditis complicated by systemic septic embolization and started large doses of two kinds of antibiotic therapy, as well as immediate management of mild right heart

show abstract

Changing Profile of Infective Endocarditis<SUBTITLE>Results of a 1-Year Survey in France</SUBTITLE>

Abstract: Although the incidence of IE has not changed, important changes in disease characteristics, treatment, and outcomes were noted.

Cited by 864 publications

References 20 publications

Antimicrobial Susceptibilities of Abiotrophia defectiva, Granulicatella adiacens, and Granulicatella elegans

Antimicrobial Susceptibilities of Abiotrophia defectiva, Granulicatella adiacens, and Granulicatella elegans

Streptococcus oralis Neuraminidase Modulates Adherence to Multiple Carbohydrates on Platelets

Dual-sided Infective Endocarditis due to Atrial Septal Aneurysm With Patent Foramen Ovale

Contact Info

Product

Resources

About