Changing patterns of Serum CEA and CA199 for Evaluating the Response to First-line Chemotherapy in Patients with Advanced Gastric Adenocarcinoma

Zhang, Huiqing; Xiong, Shuping; Lu, Shan; Wan, Yiye; Song, Rongfeng

doi:10.7314/apjcp.2015.16.8.3111

Cited by 12 publications

(7 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several tumor markers, for example, CEA, CA125, CA199 and CA724, are included in community-based cancer screening programs. [6][7][8] It has been reported, however, that not all cases with CRC have elevated tumor indices. This is because the specificity and sensitivity of these tumor markers are not high enough for the precise detection of CRC, leading to low rates of detection and diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Detection and Clinical Value of Circulating Tumor Cells as an Assisted Prognostic Marker in Colorectal Cancer Patients

Pan¹,

Hao²,

Sun³

et al. 2021

CMAR

View full text Add to dashboard Cite

Background: Circulating tumor cells (CTCs) are cells that have been shed into the vasculature from a primary tumor and circulate in the bloodstream. It has been suggested that detecting CTCs could help the clinician to detect early metastasis or recurrence more effectively. This trial sets out to assess the detection and clinical value of CTCs as an assisted prognostic marker in patients with colon cancer and rectal cancer. Methods: A prospective cohort of patients with colorectal cancer (CRC) was enrolled from July 2015 to February 2018 in

show abstract

Section: Introductionmentioning

confidence: 99%

Detection and Clinical Value of Circulating Tumor Cells as an Assisted Prognostic Marker in Colorectal Cancer Patients

Pan¹,

Hao²,

Sun³

et al. 2021

CMAR

View full text Add to dashboard Cite

show abstract

“…[9–11] However, according to the current knowledge, most previous studies on TMs focused on their use as prognostic indicators, predicting the efficacy of both first-line chemotherapy and postsurgical surveillance in GC. [12–14] There are few studies on predictive screening or early detection, particularly for CA72-4.…”

Section: Introductionmentioning

confidence: 99%

Clinical significance and diagnostic value of serum CEA, CA19-9 and CA72-4 in patients with gastric cancer

et al. 2016

View full text Add to dashboard Cite

AimsTo evaluate the clinical significance of multiple serum tumor markers (TMs) in the diagnosis of gastric cancer (GC) and establish an accurate discriminant equation to identify the presence of GC.ResultsThe serum levels of CEA, CA19-9 and CA72-4 were higher in the GC group than in the control group (P < 0.005). The sensitivity of CEA, CA19-9 and CA72-4 in the diagnosis of GC was 20.1–27.6% individually and increased to 48.2% when they were considered in combination. By using the optimal cut-off value, the sensitivity of CEA, CA19-9 and CA72-4 for the diagnosis of GC was improved but remained unsatisfactory. In addition, we developed the equation Y = −2.185 − 0.015 X1 + 0.180 X2 + 1.226 X3 + 1.505 X4 + 2.749 X5 (X1 = Age, X2 = Sex, X3 =CEA, X4 = CA19-9 and X5 = CA72-4) to predict the presence of GC. This has better accuracy and diagnostic efficiency compared to the combination of TMs.MethodsSerum carcinoembryonic antigen (CEA), cancer antigen 19-9 (CA19-9)and cancer antigen 72-4 (CA72-4) levels were measured in a total of 2288 patients with GC and 1869 healthy volunteers or patients with benign gastric diseases. We established a diagnostic equation using a portion of the data (training set), and validate its accuracy using the other portion of the data (testing set).ConclusionsThe diagnostic equation increases the accuracy rate for the diagnosis of GC and will be helpful in the clinic.

show abstract

“…Zhou et al ( 23 ) found that CA199 ≥14.06 U/mL and CA125 ≥14.30 U/mL were predictors of endometrial carcinogenesis when entered into the risk mode. The variation of CEA and CA19-9 levels in serum can accurately predict the efficacy of first-line chemotherapy in advanced GC ( 24 ). In our research, serum expression levels of PVT1 and CA19-9 showed a correlation in Han GC patients.…”

Section: Discussionmentioning

confidence: 99%

Expression levels and the prognostic value of long non-coding RNA PVT1 in serum of Han and Uygur gastric cancer patients in Xinjiang, China

Ren¹,

Liu²,

Yang³

et al. 2019

Transl. Cancer Res

View full text Add to dashboard Cite

Background The expression level of a long non-coding RNA (lncRNA), plasmacytoma variant translocation 1 (PVT1), was studied in serum of Han and Uygur gastric cancer (GC) patients and normal persons in Xinjiang, China, and the prognostic value of PVT1 was analyzed. Methods We collected serum samples from 87 GC patients (51 Han and 36 Uygur), and 95 normal persons (55 Han and 40 Uygur). Total RNA was extracted from the serum and used for real-time polymerase chain reaction (PCR) to detect the level of PVT1.The relationships between PVT1 and clinicopathological features were analyzed using the Spearman’s relative analysis, rank sum test, and χ 2 test. At the same time, selection electrochemiluminescence was used to detect the concentration of serum tumor markers, including alpha fetoprotein (AFP), carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), and carbohydrate antigen 72-4 (CA72-4). The correlation between PVT1 and the tumor markers was analyzed by Spearman’s relative analysis. Results The serum expression level of PVT1 was higher than that of the normal group in both Han and Uygur GC patients (P<0.05). PVT1 expression in Uygur GC serum was higher than that of Han patients (P<0.05). The high level of serum PVT1 correlated with lymph node metastasis in both Han and Uygur GC patients (P<0.05). Compared with Han GC patients, the Uygur people were more likely to develop distant metastasis (P<0.05). Uygur patients were more often diagnosed at stage III or IV (P<0.05). In addition, serum PVT1 showed a significant correlation with CA19-9 in Han GC patients (P<0.05). Conclusions Increased serum PVT1 level may indicate an increased tendency for lymphatic metastasis, especially in Uygur GC patients. When combined with CA19-9, the PVT1 expression level may be a better diagnostic marker in Han GC patients.

show abstract

Changing patterns of Serum CEA and CA199 for Evaluating the Response to First-line Chemotherapy in Patients with Advanced Gastric Adenocarcinoma

Cited by 12 publications

References 23 publications

Detection and Clinical Value of Circulating Tumor Cells as an Assisted Prognostic Marker in Colorectal Cancer Patients

Detection and Clinical Value of Circulating Tumor Cells as an Assisted Prognostic Marker in Colorectal Cancer Patients

Clinical significance and diagnostic value of serum CEA, CA19-9 and CA72-4 in patients with gastric cancer

Expression levels and the prognostic value of long non-coding RNA PVT1 in serum of Han and Uygur gastric cancer patients in Xinjiang, China

Contact Info

Product

Resources

About