Changing patterns of coeliac disease frequency: an analysis of Coeliac Society membership records.

Langman, M. J. S.; McConnell, Thomas H.; Spiegelhalter, D; McConnell, R. B.

doi:10.1136/gut.26.2.175

Cited by 21 publications

(11 citation statements)

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“…Nevertheless, considering only hospital and biopsied cases, several reports in Europe give the incidence to be between 1 : 500 and 1:1500 live births. Within this estimated incidence (the real incidence is in fact the unknown sum of 'known and biopsed' cases + the cases that were never referred to hospitals or were asymptomatic in childhood), a decrease in the incidence of the disease has been reported [11].…”

Section: Discussionmentioning

confidence: 98%

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Unchanging clinical picture of coeliac disease presentation in Campania, Italy

et al. 1989

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Four hundred and sixty-three new diagnoses of coeliac disease in children were made during 1973 to 1986 in our department. The distribution of new diagnoses per year did not show any decreasing trend in the period 1973 to 1986. No changing trend in breast feeding attitudes was found in the region during the same period. Analysis of the clinical pattern showed a constant distribution of age at diagnosis, onset of first symptoms and nature of symptoms throughout the period studied. These data suggest that coeliac disease is predominantly genetically determined and its expression is modulated by individual and environmental factors. The stability of the observed prevalence of the disease is parallel to the unchanging pattern of breast feeding attitudes in the region.

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Section: Discussionmentioning

confidence: 98%

“…A changing pattern in the presentation of coeliac disease has been reported in several countries [11]. A decreasing frequency has been documented together with a change in the prevalence of specific symptoms in relation to the age at diagnosis [3,12,14].…”

Section: Introductionmentioning

confidence: 99%

Unchanging clinical picture of coeliac disease presentation in Campania, Italy

et al. 1989

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“…Even though not ordinarily dependent on calcium or vitamin that celiac disease is disappearing [10][11][12]. In fact, this concept was very likely due to a referral bias, since it was D malabsorption, a decreased bone mineral density is common in untreated celiac disease [29].…”

Section: Introductionmentioning

confidence: 99%

Clinical Features of Celiac Disease Today

Collin

Kaukinen

Mäki³

1999

Dig Dis

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The clinical spectrum of celiac disease has widened over the past decades. The condition is no longer a severe malabsorption syndrome. Instead, a typical celiac disease patient today has merely mild abdominal symptoms. Malabsorption can be subclinical or absent, and there is usually only moderate, if any, loss of weight. Simultaneously, the current prevalence has increased from 1:1,000 to 1:300 inhabitants, or even higher. Clinically silent celiac disease cases are being detected in increasing numbers since the introduction and widespread use of serologic screening tests. Symptoms of celiac disease can appear outside the intestine, a typical example being dermatitis herpetiformis. Gluten intolerance is no longer limited to overt villous atrophy. Inflammation without villous damage may be observed in genetically susceptible individuals. The term latent celiac disease is applied in situations where the patient has normal villous architecture while on a gluten-containing diet, but later develops small bowel villous atrophy compatible with celiac disease.

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“…Breast fed babies presented later than bottle fed babies (14 compared with 9 months) despite a similar age of gluten introduction. Similarly bottle fed babies and breast fed babies presented later after 1975 (10-5 compared with 7 months, and 18 compared with 9-5 months, respectively). Before 1975 the median age of gluten introduction was significantly less than that after 1975 (2 compared with 4 months) and the age of gluten introduction correlated with the age of presentation.…”

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confidence: 99%