Changing pattern of gonadotropins in a patient with an adrenal-androgen secreting tumor

Marcondes, José Antônio Miguel; Barcellos, Cristiano Roberto Grimaldi; Rocha, Marco; Bisi, Hélio

doi:10.1590/s1807-59322011000200029

Cited by 5 publications

(2 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The ovary is an important source for androgen excess in women with polycystic ovary syndrome (PCOS) [ 1 , 2 ] and androgen-secreting tumours [ 3 ]. Augmentation in the peripheral blood androgen levels is found in patients suffering from adrenal hyperplasia [ 4 ] and androgen-secreting tumours [ 5 , 6 ]. Blood androgen levels are elevated in pigs with uterine inflammation [ 7 ] and polycystic ovaries [ 8 ], and in dogs with adrenal dysfunction [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Long-term treatment with testosterone alters ovary innervation in adult pigs

et al. 2016

View full text Add to dashboard Cite

BackgroundIntraovarian distribution and density of nerve fibres immunoreactive (IR) to protein gene product 9.5 (PGP 9.5) and containing dopamine-β-hydroxylase (DβH), neuropeptide Y (NPY), somatostatin (SOM), galanin (GAL) were determined.MethodsFrom day 4 of the first oestrous cycle to day 20 of the second studied cycle, experimental gilts (n = 3) were injected with testosterone (T), while control gilts (n = 3) received corn oil.ResultsAfter T administration the numbers of fibres IR to PGP 9.5 and fibres IR to DβH, NPY and SOM were decreased. Fewer PGP 9.5- and DβH-IR terminals were observed within the ground plexus and around arteries and medullar veins, and medium tertiary follicles, and DβH-IR terminals in the vicinity of small tertiary follicles. T decreased the density of NPY-IR fibres in the medullar part of the ground plexus, and SOM-IR in the cortical part of the ground plexus.ConclusionsThe obtained data show that long-term T treatment of gilts decreases the total number of intraovarian fibres, including sympathetic ones. These results suggest that elevated T levels that occur during pathological states may affect the innervation pattern of ovaries, and their function(s).

show abstract

Section: Introductionmentioning

confidence: 99%

Long-term treatment with testosterone alters ovary innervation in adult pigs

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Many pathological processes occurring in the endocrine glands of both women and animal females may cause significant disturbances in their steroidogenic activity, which results in changes in the patterns of circulating steroid hormones. Hyperandrogenism in women is caused mainly by polycystic ovary syndrome , adrenal hyperplasia , as well as by ovarian and adrenal androgen‐secreting tumours. The marked increase in the blood plasma androgens concentrations also accompanies uterine inflammation in gilts .…”

mentioning

confidence: 99%

Reduction of the Number of Neurones in the Caudal Mesenteric Ganglion Innervating the Ovary in Sexually Mature Gilts Following Testosterone Administration

Jana

Rytel

Czarzasta

et al. 2013

J Neuroendocrinology

View full text Add to dashboard Cite

The effect of testosterone on the morphological and chemical plasticity of the porcine caudal mesenteric ganglion (CaMG) ovary‐projecting neurones was investigated. To identify the neurones on day 3 of the oestrous cycle, the ovaries of both the control and experimental gilts were injected with Fast Blue retrograde neuronal tracer. From next day until day 20 of the anticipated second studied cycle, experimental gilts were injected with testosterone, whereas control gilts received oil. Testosterone injections increased testosterone (by approximately 3.5‐fold) and 17β‐oestradiol (by approximately 1.6‐fold) levels in the peripheral blood and decreased the following in the CaMG: the total number of Fast Blue‐positive perikarya (including small ones); the population of small perikarya in the caudal, ventral and dorsal ganglional regions; the numbers of dopamine‐β‐hydroxylase (DβH) and/or neuropeptide Y (NPY), somatostatin (SOM), galanin (GAL) small and large perikarya; the numbers of small perikarya containing DβH (but not NPY, SOM, GAL); and the density of DβH and/or NPY, SOM nerve fibres. A disappearance of small and large non‐noradrenergic perikarya and an increase in the total number of androgen receptor‐immunoreactive perikarya was noted. Our results suggest that elevated androgen levels occurring during pathological states may regulate ovary function(s) by affecting the CaMG gonad‐supplying neurones.

show abstract