Changing mortality of peptic ulcer disease in Germany

Sonnenberg, Amnon; Fritsch, A

doi:10.1016/0016-5085(83)90379-7

Cited by 47 publications

(14 citation statements)

References 19 publications

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“…Over the last few years a decrease in the prevalence of uncomplicated gastroduodenal peptic ulcer expressed as a decline in hospital admission rates and mortality from peptic ulcer has been reported 1, 2 . In contrast to these general trends, some studies have shown an increase in the mortality rates from duodenal ulcers and in the admissions for perforated peptic ulcers in western countries 3–5 especially among the elderly 6, 7 …”

Section: Introductionmentioning

confidence: 99%

Clinical trends in ulcer diagnosis in a population with high prevalence of Helicobacter pylori infection

Pérez-Aisa¹,

Pino

Siles

et al. 2004

Aliment Pharmacol Ther

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SUMMARYBackground: It is unknown whether the incidence of peptic ulcer changes in areas with a high prevalence of Helicobacter pylori infection. Aim: To determine trends in peptic ulcer complications in a community with a high prevalence of H. pylori infection. Methods: New endoscopic diagnoses of peptic ulcers and their complications from 1985 to 2000 were obtained. H. pylori infection in the adult population, the number of prescriptions for anti-secretory drugs and non-steroidal anti-inflammatory drugs were also evaluated. Results: Although the global prevalence of H. pylori infection remains high in this population (>60%), a 41.4

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Section: Introductionmentioning

confidence: 99%

Clinical trends in ulcer diagnosis in a population with high prevalence of Helicobacter pylori infection

Pérez-Aisa¹,

Pino

Siles

et al. 2004

Aliment Pharmacol Ther

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“…[5][6][7] Similar patterns have been noted in other Western countries 8-10 although a recent Danish study showed that hospitalisation and mortality from peptic ulcer complications have increased, especially among the elderly. 11 This general decline in hospital admission rates and mortality from peptic ulcer has been attributed to a reduced prevalence of Helicobacter pylori infection, 10 and a recent review stated that: "Peptic ulcer seems to be on the way out". 9 The rise in mortality and admissions among older women in the 1970s and 1980s has been attributed to increased prescribing of nonsteroidal anti-inflammatory drugs (NSAID), the other major cause of peptic ulcer, commonly used in older subjects.…”

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confidence: 99%

Recent trends in admissions and mortality due to peptic ulcer in England: increasing frequency of haemorrhage among older subjects

Higham

2002

Gut

209

128

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Background: Although overall admission rates for peptic ulcer in England declined from the 1950s up until the mid 1980s, perforations among older women increased, possibly due to increasing use of non-steroidal anti-inflammatory drugs (NSAID). Since then, proton pump inhibitors, antibiotic treatment for Helicobacter pylori, low dose aspirin, and selective serotonin reuptake inhibitors (SSRI) have been introduced Aims: To determine time trends for hospital admissions for peptic ulcer from 1989 to 1999 (England), mortality from 1958 to 1998 (England and Wales), and prescriptions for ulcer healing drugs, aspirin, NSAID, oral anticoagulants, and SSRI from 1990 to 1999 (England). Methods: Hospital episode statistics for admissions and mortality were obtained from the Office of National Statistics: community prescription data from Statistics Division 1E of the Department of Health. Results: Between 1989/90 and 1998/99, there was a marked rise in admissions for haemorrhage in older patients, particularly from duodenal ulcer. Perforations from gastric ulcer declined but perforations from duodenal ulcer increased among men at older ages. Since the mid 1980s mortality has declined in all age groups except for older women with duodenal ulcer. The number of prescriptions for histamine H 2 receptor antagonists remained constant but those for proton pump inhibitors increased by 5000%, aspirin 75mg by 460%, oral anticoagulants by 200%, and NSAID by 13% between 1990 and1999. Since the introduction of SSRI in 1991, prescriptions have increased 15-fold. Conclusions: Admission rates for gastric and duodenal ulcer haemorrhage and duodenal ulcer, but not gastric ulcer perforation, increased among older subjects, over a time when prescriptions for proton pump inhibitors, low dose aspirin, oral anticoagulants, and SSRI increased.

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“…Enter Amnon Sonnenberg. From 1984 on he applied birth cohort analysis to explore time trends in the mortality of a variety of gastrointestinal diseases [4][5][6][7], but it was not until the early 1990s that the crucial influence of H. pylori infection became apparent [8,9].…”

mentioning

confidence: 99%

Gastric Cancer: A Well-Behaved Helicobacter pylori-Related Disease?

Genta

2011

Dig Dis Sci

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Changing mortality of peptic ulcer disease in Germany

Cited by 47 publications

References 19 publications

Clinical trends in ulcer diagnosis in a population with high prevalence of Helicobacter pylori infection

Clinical trends in ulcer diagnosis in a population with high prevalence of Helicobacter pylori infection

Recent trends in admissions and mortality due to peptic ulcer in England: increasing frequency of haemorrhage among older subjects

Gastric Cancer: A Well-Behaved Helicobacter pylori-Related Disease?

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