Changing levels of selenium and zinc in cadmium-exposed workers: probable association with the intensity of inflammation

Türksoy, Vugar Ali; Tutkun, Lütfiye; Gündüzöz, Meşide; Öztan, Özgür; Deniz, Serdar; İritaş, Servet Birgin

doi:10.1007/s11033-019-05001-4

Cited by 14 publications

(7 citation statements)

References 42 publications

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“…Karri et al reported significant differences in the expression of protein information between heavy metal mixtures and single metals and demonstrated that the health risks of metal mixture exposure are a greater threat than those of single-metal exposure [ 50 ]. Among toxic and essential metals, Turksoy et al found that the levels of Se and Zn affected the concentrations of TNF-α, IL-6, and IL-10 [ 51 ]. Even excessive levels of essential elements may induce adverse health effects.…”

Section: Discussionmentioning

confidence: 99%

Use of Generalized Weighted Quantile Sum Regressions of Tumor Necrosis Factor Alpha and Kidney Function to Explore Joint Effects of Multiple Metals in Blood

Luo

Yang³

et al. 2022

IJERPH

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Exposure to heavy metals could lead to adverse health effects by oxidative reactions or inflammation. Some essential elements are known as reactors of anti-inflammatory enzymes or coenzymes. The relationship between tumor necrosis factor alpha (TNF-α) and heavy metal exposures was reported. However, the interaction between toxic metals and essential elements in the inflammatory response remains unclear. This study aimed to explore the association between arsenic (As), cadmium (Cd), lead (Pb), cobalt (Co), copper (Cu), selenium (Se), and zinc (Zn) in blood and TNF-α as well as kidney function. We enrolled 421 workers and measured the levels of these seven metals/metalloids and TNF-α in blood; kidney function was calculated by CKD-EPI equation. We applied weighted quantile sum (WQS) regression and group WQS regression to assess the effects of metal/metalloid mixtures to TNF-α and kidney function. We also approached the relationship between metals/metalloids and TNF-α by generalized additive models (GAM). The relationship of the exposure–response curve between Pb level and TNF-α in serum was found significantly non-linear after adjusting covariates (p < 0.001). Within the multiple-metal model, Pb, As, and Zn were associated with increased TNF-α levels with effects dedicated to the mixture of 50%, 31%, and 15%, respectively. Grouped WQS revealed that the essential metal group showed a significantly negative association with TNF-α and kidney function. The toxic metal group found significantly positive associations with TNF-α, serum creatinine, and WBC but not for eGFR. These results suggested Pb, As, Zn, Se, and mixtures may act on TNF-α even through interactive mechanisms. Our findings offer insights into what primary components of metal mixtures affect inflammation and kidney function during co-exposure to metals; however, the mechanisms still need further research.

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Section: Discussionmentioning

confidence: 99%

Use of Generalized Weighted Quantile Sum Regressions of Tumor Necrosis Factor Alpha and Kidney Function to Explore Joint Effects of Multiple Metals in Blood

Luo

Yang³

et al. 2022

IJERPH

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“…Mercury and MeHg exposure in humans have previously been related to induced inflammatory responses by proinflammatory cytokine expression [ 63 ]. Studies on selenium have in contrast revealed protecting mechanisms on inflammation and immune response such as reduced intensity of inflammatory markers like IL-6, IL-10 and TNF-α [ 64 ]. Low selenium levels have been connected to different inflammatory states and infections possibly indicating that stress, inflammation and infections may be influenced by selenium availability [ 65 ].…”

Section: Discussionmentioning

confidence: 99%

Dietary Selenomethionine Reduce Mercury Tissue Levels and Modulate Methylmercury Induced Proteomic and Transcriptomic Alterations in Hippocampi of Adolescent BALB/c Mice

Mellingen

Myrmel

Rasinger

et al. 2022

IJMS

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Methylmercury (MeHg) is a well-known environmental contaminant, particularly harmful to the developing brain. The main human dietary exposure to MeHg occurs through seafood consumption. However, seafood also contains several nutrients, including selenium, which has been shown to interact with MeHg and potentially ameliorate its toxicity. The aim of this study was to investigate the combined effects of selenium (as selenomethionine; SeMet) and MeHg on mercury accumulation in tissues and the effects concomitant dietary exposure of these compounds exert on the hippocampal proteome and transcriptome in mice. Adolescent male BALB/c mice were exposed to SeMet and two different doses of MeHg through their diet for 11 weeks. Organs, including the brain, were sampled for mercury analyses. Hippocampi were collected and analyzed using proteomics and transcriptomics followed by multi-omics bioinformatics data analysis. The dietary presence of SeMet reduced the amount of mercury in several organs, including the brain. Proteomic and RNA-seq analyses showed that both protein and RNA expression patterns were inversely regulated in mice receiving SeMet together with MeHg compared to MeHg alone. Several pathways, proteins and RNA transcripts involved in conditions such as immune responses and inflammation, oxidative stress, cell plasticity and Alzheimer’s disease were affected inversely by SeMet and MeHg, indicating that SeMet can ameliorate several toxic effects of MeHg in mice.

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“…Previously, it has been seen that based on the different biological systems as well as concentrations of Cd TNF‐α were found to be significantly different, wherein most of the studies reported a significant increase in the mRNA as well as serum levels of the same. [ 13,22,28,29 ] Zhao and coworkers on the other hand reported downregulation in the mRNA expression of TNF‐α in Cd‐treated mice which varies as per the different doses. [ 30 ]…”

Section: Discussionmentioning

confidence: 99%

Plasma microRNA expression and immunoregulatory cytokines in an Indian population occupationally exposed to cadmium

Mitra

Goyal

Sharma

et al. 2022

J Biochem & Molecular Tox

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Following its accumulation in the body, cadmium (Cd) exposure is associated with devastating effects on multiple organ system of the human body. The immune system is one of the sensitive targets for Cd‐induced toxicity. Recently, studies have demonstrated a significant role of Cd in inducing epigenetic alterations. With this background, the present study was planned to study the changes in candidate microRNA (miRNA) expression associated with immune regulation in occupationally Cd‐exposed workers. One hundred individuals involved in welding and metal handicraft manufacturing, while 80 apparently healthy subjects without any prior history of occupational exposure were recruited for the study. Blood Cd level was determined by atomic absorption spectrometry. Serum cytokine levels were measured using an enzyme‐linked immunosorbent assay and serum miRNA expression of candidate miRNAs (miR‐146a, miR‐210, and miR‐222) were determined by real‐time polymerase chain reaction. The median Cd level (2.40 μg/L) in the occupationally exposed workers was significantly higher than the nonexposed subjects (0.90 μg/L). Among the cytokines, interleukin‐4 (IL‐4), and tumor necrosis factor‐alpha (TNF‐α) were significantly higher while IL‐2 and IL‐10 were significantly lower in the exposed. The expression level of miR‐146a and miR‐222 were significantly different between the groups with the former showing downregulation and later showing upregulation. Correlation analysis revealed a positive and negative association of miR‐222 and miR‐146a with blood cadmium level, IL‐17 as well as TNF‐α, respectively. Furthermore, the in‐silico analysis revealed a significant role of the studied miRNAs in various cellular and genetic pathways. The findings of the present study demonstrate significant involvement of Cd‐induced alteration in miRNAs in varied immune regulatory changes in exposed individuals.

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Changing levels of selenium and zinc in cadmium-exposed workers: probable association with the intensity of inflammation

Cited by 14 publications

References 42 publications

Use of Generalized Weighted Quantile Sum Regressions of Tumor Necrosis Factor Alpha and Kidney Function to Explore Joint Effects of Multiple Metals in Blood

Use of Generalized Weighted Quantile Sum Regressions of Tumor Necrosis Factor Alpha and Kidney Function to Explore Joint Effects of Multiple Metals in Blood

Dietary Selenomethionine Reduce Mercury Tissue Levels and Modulate Methylmercury Induced Proteomic and Transcriptomic Alterations in Hippocampi of Adolescent BALB/c Mice

Plasma microRNA expression and immunoregulatory cytokines in an Indian population occupationally exposed to cadmium

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