Changing indications for preimplantation genetic diagnosis (PGD)

Simpson, Joe Leigh

doi:10.1016/s0303-7207(01)00573-1

Cited by 18 publications

(9 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…238 However, others argue that having a child with inherited susceptibility to cancer could be a major source of suffering for parents and child. 239 If genetic tests for nonmedical multifactorial traits such as strength, intelligence, sexual orientation or other factors become available, the impact of PGD might be important. However, such tests, with a few exceptions, are unlikely to become available.…”

Section: Acceptability Of Genetic Testing and Screeningmentioning

confidence: 99%

The interface between assisted reproductive technologies and genetics: technical, social, ethical and legal issues

et al. 2006

View full text Add to dashboard Cite

Section: Acceptability Of Genetic Testing and Screeningmentioning

confidence: 99%

The interface between assisted reproductive technologies and genetics: technical, social, ethical and legal issues

et al. 2006

View full text Add to dashboard Cite

“…In addition, incidence of chromosomal trisomy is closely associated with increased maternal age (Verlinsky and Kuliev, 1996). It was reported that among all PGD cases currently performed worldwide, two-third of the cases are those using FISH to screen embryonic aneuploidy for women with advanced age (Simpson, 2001). Embryonic chromosomal aberrations are generated from two types of non-disjunction: non-disjunction occurring during gamete meiosis results in embryonic aneuploidy; non-disjunction occurring during zygote mitosis leads to mosaic chromosomal abnormality.…”

Section: Discussionmentioning

confidence: 99%

Identification of embryonic chromosomal abnormality using FISH-based preimplantaion genetic diagnosis

Fan

et al. 2004

J. Zheijang Univ.-Sci.

View full text Add to dashboard Cite

Abstract:Objective: Embryonic chromosomal abnormality is one of the main reasons for in vitro fertilization (IVF) failure. This study aimed at evaluating the value of Fluorescence in-situ Hybridization (FISH)-based Preimplantation Genetic Diagnosis (PGD) in screening for embryonic chromosomal abnormality to increase the successful rate of IVF. Method: Ten couples, four with high risk of chromosomal abnormality and six infertile couples, underwent FISH-based PGD during IVF procedure. At day 3, one or two blastomeres were aspirated from each embryo. Biopsied blastomeres were examined using FISH analysis to screen out embryos with chromosomal abnormalities. At day 4, embryos without detectable chromosomal abnormality were transferred to the mother bodies as in regular IVF. Results: Among 54 embryos screened using FISH-based PGD, 30 embryos were detected to have chromosomal abnormalities. The 24 healthy embryos were implanted, resulting in four clinical pregnancies, two of which led to successful normal birth of two healthy babies; one to ongoing pregnancy during the writing of this article; and one to ectopic pregnancy. Conclusion: FISH-based PGD is an effective method for detecting embryonic chromosomal abnormality, which is one of the common causes of spontaneous miscarriages and chromosomally unbalanced offsprings.

show abstract

“…The recent development of comprehensive chromosome screening of all 23 pairs of chromosomes by microarrays or the so-called preimplantation genetic screening (PGS) for aneuploidies and translocation in human embryos was achieved [2]. In the last decade, the PGD list was expanded for other purposes such as cancer predisposition disorders, rhesus incompatibility, mitochondrial disorders, and human leukocyte antigen typing [3–8]. Nowadays, PGD could be offered for any disorder for which molecular testing can be performed.…”

Section: Introductionmentioning

confidence: 99%

New Advances of Preimplantation and Prenatal Genetic Screening and Noninvasive Testing as a Potential Predictor of Health Status of Babies

Milachich

2014

BioMed Research International

View full text Add to dashboard Cite

The current morphologically based selection of human embryos for transfer cannot detect chromosome aneuploidies. So far, only biopsy techniques have been able to screen for chromosomal aneuploidies in the in vitro fertilization (IVF) embryos. Preimplantation genetic diagnosis (PGD) or screening (PGS) involves the biopsy of oocyte polar bodies or embryonic cells and has become a routine clinical procedure in many IVF clinics worldwide, including recent development of comprehensive chromosome screening of all 23 pairs of chromosomes by microarrays for aneuploidy screening. The routine preimplantation and prenatal genetic diagnosis (PND) require testing in an aggressive manner. These procedures may be invasive to the growing embryo and fetus and potentially could compromise the clinical outcome. Therefore the aim of this review is to summarize not only the new knowledge on preimplantation and prenatal genetic diagnosis in humans, but also on the development of potential noninvasive embryo and fetal testing that might play an important role in the future.

show abstract

Changing indications for preimplantation genetic diagnosis (PGD)

Cited by 18 publications

References 30 publications

The interface between assisted reproductive technologies and genetics: technical, social, ethical and legal issues

The interface between assisted reproductive technologies and genetics: technical, social, ethical and legal issues

Identification of embryonic chromosomal abnormality using FISH-based preimplantaion genetic diagnosis

New Advances of Preimplantation and Prenatal Genetic Screening and Noninvasive Testing as a Potential Predictor of Health Status of Babies

Contact Info

Product

Resources

About