Changing in lipid profile induced by the mutation of Foxn1 gene: A lipidomic analysis of Nude mice skin

The Transcription Factor FOXN1 Regulates Skin Adipogenesis and Affects Susceptibility to Diet-Induced Obesity

“…Our recent data also revealed that FOXN1 is involved in reparative (scar forming) wound healing by engaging in re-epithelialization and epithelial to mesenchymal transition (Gawronska-Kozak et al, 2016). Comparative data from Lanzini et al identified the regulatory role of FOXN1 in lipidome modification in nude (FOXN1 À/À ) versus wild-type (FOXN1 þ/þ ) mouse skin (Lanzini et al, 2015). Moreover, the decreased susceptibility to diet-induced obesity in FOXN1 À/À mice indicates the effect of FOXN1 on the regulation of fat tissue content (Hirata et al, 2011;Stemmer et al, 2015).…”

“…The possible role of FOXN1 in adipogenic compartment turnover in the skin was demonstrated through a lipidomic profile comparison study by Lanzini et al (2015). Whereas lipids associated with epidermal barrier function (phospholipids and sphingolipids) were upregulated, triacylglycerols (associated with the dermal layer of the skin) were downregulated in the skin of FOXN1 À/À mice.…”

Characterization of the Promoter Regions of Two Sheep Keratin-Associated Protein Genes for Hair Cortex-Specific Expression

“…That study also found an altered expression pattern of the KAP11-1 protein without impaired expression in the hair cortex in forkhead box N1 ( Foxn1 , also named Whn ) nu de mice [ 28 ], indicating that the expression of the KAP11-1 protein is at least partially dependent on Foxn1 activity. Foxn1 is a transcription activator that is transcribed primarily in the hair cortex and cuticle and has been established to play a role in the regulation of hair keratin gene expression [ 35 – 38 ]. It is possible that Foxn1 is a cofactor responsible for the activation of KAP11-1.…”

Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells

“…Lipidomic analysis was performed according to the previously described method 79 , on control (n = 12) and resveratrol-treated Caco2 cells (10 µM, 48 hr) (n = 12). Briefly, lipids extracts were analyzed by ultra-performance liquid chromatography coupled to high resolution mass spectrometry (UPLC-HRMS) on a Aquity TM UHPLC TM - Synapt TM G2 HDMS TM system (Waters MS Technologies, Manchester, UK).…”