Changing growth of neurites of sensory ganglion by terahertz radiation

Tsurkan, Mikhail V.; Smolyanskaya, O. A.; Bespalov, V. G.; Penniyainen, V. A.; Kipenko, A. V.; Lopatina, E. V.; Крылов, Б. В.

doi:10.1117/12.909350

Cited by 18 publications

(23 citation statements)

References 38 publications

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“…A recent study showed that exposure of mouse stem cells to 2.25-THz radiation caused gene specific transcriptional alterations and accelerated stem cell differentiation toward adipocytes [38], [39]. Furthermore, another study, showed the stimulating effect of THz radiation on nerve cells [70].…”

Section: Discussionmentioning

confidence: 99%

“…In such a scenario, THz radiation could potentially be used to selectively regulate key genes involved in specific pathways and cellular processes. Few examples include cellular reprogramming, cellular preconditioning, and nerve stimulation or repression [38], [39], [69], [70]. A recent study showed that exposure of mouse stem cells to 2.25-THz radiation caused gene specific transcriptional alterations and accelerated stem cell differentiation toward adipocytes [38], [39].…”

Section: Discussionmentioning

confidence: 99%

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Terahertz Radiation: A Non-contact Tool for the Selective Stimulation of Biological Responses in Human Cells

Echchgadda

Grundt

Cerna

et al. 2016

IEEE Trans. THz Sci. Technol.

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Collective motions of water and of many biological macromolecules have characteristic time scales on the order of a picosecond. As a result, these biomolecules can strongly absorb terahertz (THz) radiation. Due to this absorption, THz radiation can exert a diverse range of effects on biological structures. For example, THz radiation has been shown to impact the structure, functional activity, and dynamics of macromolecules such as DNA and proteins. THz radiation can affect several gene expression pathways and, consequently, can alter various biochemical and physiological processes in cells. Indeed, THz radiation has been shown to influence the expression of several genes within different cell types. However, a complete view of the global transcriptional responses and the intracellular canonical pathways specifically triggered by THz radiation has not been elucidated. In this study, we performed a global profiling of transcripts in human cells exposed to 2.52 THz radiation and compared the exposure responses to a thermally-matched bulk-heating (BH) protocol. Our resultsshow that both THz radiation and BH induce a significant change in the expression of numerous mRNAs and microRNAs. The data also show that THz radiation triggers specific intracellular canonical pathways that are not affected in the BH-exposed cells. This study implies that THz radiation may be a useful, non-contact tool for the selective control of specific genes and cellular processes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Terahertz Radiation: A Non-contact Tool for the Selective Stimulation of Biological Responses in Human Cells

Echchgadda

Grundt

Cerna

et al. 2016

IEEE Trans. THz Sci. Technol.

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“…Detailed description of the setup is given in the article [20]. The generated THz radiation had a frequency band from 0.05 to 1.2 THz.…”

Section: Experimental Setup Objects and Methodsmentioning

confidence: 99%

Impact of terahertz radiation on cells

Tsurkan¹,

Smolyanskaya²

2013

2013 Asia-Pacific Microwave Conference Proceedings (APMC)

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Knowledge of the biological effects induced by THz radiation can have a crucial impact in future developments in fields of medicine, biology or chemistry. The lack of THz radiation sources with sufficient power as well as the missing knowledge of the specifics of their use led to the fact that the impact of microwave radiation on different organisms, including microorganisms has not yet been investigated. The aim of our study was to assess the impact of broadband pulsed THz radiation in the frequency range of 0.05 to 1.2 THz on cell systems. Studies conducted in vitro.

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“…1, 10 We took as a basis the circuit of a THz radiator developed for the irradiation of nerve cells. 11 It was updated for the irradiation of cells immersed in a liquid medium. Since such cells deposit on the bottom of the cell-culture plate, it is necessary to suppress the radiation from below.…”

Section: Methodsmentioning

confidence: 99%

“…The femtosecond radiation reflected from the crystal was absorbed in a fluoroplastic filter in front of mirror 6. Next, the part of the radiation transmitted through the beamsplitter plate was focused by a lens with focal length 5 cm (10) onto a GC-1P optoacoustic detector (OAD) (Tydex Corp.) with sensitivity 1 × 10 5 V∕W and response rate 30 ms (11). Another part of the radiation, reflected from the silicon plate, was incident on a second parabolic mirror (8), which directed the radiation in the form of a convergent beam upwards toward the object (9).…”

Section: Methodsmentioning

confidence: 99%

Study of the action of broad-band terahertz radiation on the functional activity of cells

et al. 2013

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In order to determine the limits of the biologically safe maximum allowable levels of pulsed terahertz (THz) radiation, a prototype of apparatus has been developed for the irradiation of cell cultures immersed in a liquid medium with broad-band THz radiation in the 0.05-1.2 THz frequency range. The action of THz radiation on the functional activity of the cells of a number of biological cultures, including mouse thymocytes and splenocytes, has been investigated. This was evaluated by means of flow-through cytometry, using fluorescence-intensity analysis of DNAbinding stains. It is shown that THz radiation with a mean power density of up to 10 μW∕cm 2 and a time of action of 1 min has no effect on the variation of the functional activity of the cells. No statistically reliable variations were detected in the relationship of living cells and cells at different stages of apoptosis or in the distribution of cells over the phases of the cellular cycle. It is concluded that THz radiation with such characteristics can be used for medical spectroscopy.

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Changing growth of neurites of sensory ganglion by terahertz radiation

Cited by 18 publications

References 38 publications

Terahertz Radiation: A Non-contact Tool for the Selective Stimulation of Biological Responses in Human Cells

Terahertz Radiation: A Non-contact Tool for the Selective Stimulation of Biological Responses in Human Cells

Impact of terahertz radiation on cells

Study of the action of broad-band terahertz radiation on the functional activity of cells

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