Changing Epidemiology: Does It Increase Our Understanding?

Humes, David J.

doi:10.1159/000335692

Cited by 25 publications

(22 citation statements)

References 66 publications

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“…Our understanding of this disease [36] has been improved by the recent, extensive reports that have based their data on administrative data. The present study validated the administrative data by examining the case records of every patient, thus excluding patients with diverticular disease who did not have acute colonic diverticulitis.…”

Section: Discussionmentioning

confidence: 99%

Major increase in admission- and incidence rates of acute colonic diverticulitis

Talabani

Lydersen

Endreseth

et al. 2014

Int J Colorectal Dis

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PurposeHospitalization for acute colonic diverticulitis has become more and more frequent. We studied the changes in the rate of admission and incidence of the disease during the last 25 years.MethodsWe performed a retrospective analysis of all cases treated for acute diverticulitis during 1988–2012 at one hospital serving a defined population in Mid-Norway. The study made a distinction between admission rates and incidence rates. The admission rates defined the total number of cases admitted, while the incidence rates defined the number of new patients hospitalized for acute diverticulitis (first admission). Poisson regression was used to analyse factors associated with diverticulitis incidence rates.ResultsA total of 851 admissions in 650 different patients were identified, with an overall admission rate of 38.5 (CI 35.9 to 41.1) per 100,000 person-years. The admission rate increased from 17.9 (CI 14.1 to 22.3)/100,000 during 1988–1992 to 51.1 (CI 44.8 to 58.0)/100,000 during 2008–2012. Poisson regression analysis showed a significant increase in admission rates with a factor of 2.8 (C.I. 2.2 to 3.5) during 25 years. The overall incidence rate (IRR) of new patients was 29.4 (CI 27.1 to 31.7)/100,000 person-years. IRR increased significantly with a factor of 2.6 (CI 1.96 to 3.34) during 25 years, while IRR for perforations increased even more, by a factor of 3.3 (CI 1.24 to 8.58).ConclusionThe hospital admission rates as well as incidence rates for acute colonic diverticulitis increased significantly during the 25-year time span.

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Section: Discussionmentioning

confidence: 99%

Major increase in admission- and incidence rates of acute colonic diverticulitis

Talabani

Lydersen

Endreseth

et al. 2014

Int J Colorectal Dis

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“…Die Prävalenz der Divertikelkrankheit steigt mit dem Lebensalter an (z.B. von 0.17 auf 5.74 pro 1000 in den Altersgruppe bis 15-44 Jahre und >75 Jahre) [66,175].…”

Section: Kommentar Zu Statement 37unclassified

Failure to Use Ultrasound Is a Glaring Shortcoming

Läng¹

2018

Deutsches Ärzteblatt International

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“…This may allow chronic inflammation and epithelial cell proliferation in and around the diverticula. 34 Probiotics, restoring the colonic microenvironment, have been proposed to treat those patients. 35 The most recently published RCT in Diverticulosis compared mesalazine or mesalazine plus Bifidobacterium infantis 35624 for 12 weeks and followed up for nine additional months.…”

Section: Indications Of Probioticsmentioning

confidence: 99%

Proboitics and their Role in GI Diseases

Perveen

Ahmed

2017

J. Bangladesh Coll. Phys.

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Data Synthesis: The need for objective, evidence-based guidance on the role of probiotics is becoming increasingly important as public awareness grows. This consensus is intended as a practical reference to help physicians make appropriate, evidence-based recommendations to patients who might benefit from probiotic treatment. Overall, the randomised, placebo-controlled trials included in this article support, with a high evidence level, the therapeutic effects of probiotic agents for several disorders including antibiotic or Clostridium difficile-associated diarrhea, irritable bowel syndrome, and the inflammatory bowel diseases. Although probiotic research is a rapidly evolving field, there are sufficient data to justify a trial of probiotics for treatment or prevention of some of these conditions. However, the capacity of probiotics to modify disease symptoms is likely to be modest and varies among probiotic strains and not all probiotics are right for all diseases. The goal of this review is to provide clinicians with an overview of the rationale and data which support or refute the role of probiotics for treating commonly encountered gastrointestinal disorders.

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Changing Epidemiology: Does It Increase Our Understanding?

Cited by 25 publications

References 66 publications

Major increase in admission- and incidence rates of acute colonic diverticulitis

Major increase in admission- and incidence rates of acute colonic diverticulitis

Failure to Use Ultrasound Is a Glaring Shortcoming

Proboitics and their Role in GI Diseases

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