Changing epidemiologic pattern of chronic hepatitis C virus infection in Italian children

Bortolotti, Flavia; Resti, Massimo; Giacchino, Raffaella; Crivellaro, Carlo; Zancan, Lucia; Azzari, Chiara; Gussetti, Nadia; Tasso, Loredana; Faggion, S.

doi:10.1016/s0022-3476(98)70273-2

Cited by 66 publications

(28 citation statements)

References 19 publications

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“…The presence of transient viremia should be regarded as a consequence of spontaneous viral clearance after MTCT [31,36,46]. Most studies have not been able to establish a clear association between HCV genotype and MTCT [26,47,48]. One study suggested that genotypes 1b and 3a are associated with MTCT of HCV, although they were also more prevalent in HCV/HIV-coinfected mothers [38].…”

Section: Discussionmentioning

confidence: 99%

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Mother-to-Child Transmission of Hepatitis C Virus (HCV) Among HIV/HCV-Coinfected Women

Cabot

Stoszek

Quarleri

et al. 2012

Journal of the Pediatric Infectious Diseases Society

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Background. Maternal human immunodeficiency virus (HIV) coinfection has been associated with increased hepatitis C virus (HCV) mother-to-child transmission (MTCT). We hypothesized that HCV/HIVcoinfected women with well-controlled HIV disease would not have increased HCV MTCT. Methods. The NISDI Perinatal and LILAC cohorts enrolled HIV-infected pregnant women and their infants in Latin America and the Caribbean. This substudy evaluated the HCV infection status of mothers at participating sites and their live born, singleton infants who had a 6-month postnatal visit by December 31, 2008. Mothers who were anti-HCV-positive, or who had CD4 counts (cells/mm 3 ) <200 with detectable HCV RNA, were considered HCV-infected. All HCV-infected women were tested for HCV RNA. Infants with HCV RNA were considered HCV-infected. Results. Of 1042 enrolled women, 739 (71%) mother-infant pairs met the inclusion criteria. Of the 739 women, 67 (9%) were anti-HCV-positive and 672 anti-HCV-negative [68 (10%) with CD4 counts <200; of these, 3 (4.4%) were HCV RNA-positive]. Therefore, our study population comprised 70 HCV-infected (47 with HCV RNA) and 669 HCV-uninfected women (and their infants). Factors associated with maternal HCV infection included unemployment (odds ratio [OR] = 2.58

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Section: Discussionmentioning

confidence: 99%

“…Fewer studies have examined the rates of MTCT of HCV among HIV-coinfected women with well-controlled HIV disease [7]. Acquisition of HCV infection through MTCT has become a major source of pediatric infection [26,27]. Almost all children who remain viremic after several years develop chronic hepatitis [28].…”

mentioning

confidence: 99%

Mother-to-Child Transmission of Hepatitis C Virus (HCV) Among HIV/HCV-Coinfected Women

Cabot

Stoszek

Quarleri

et al. 2012

Journal of the Pediatric Infectious Diseases Society

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“…Blood transfusion is the principal route of transmission of HCV in children [2] . Recent evidence sug gests that new cases are due to perinatal (vertical) transmission [3] . Eg ypt has the highest prevalence of adult HCV infection in the world, averaging 15%-25% in rural communities [4][5][6] .…”

Section: Introductionmentioning

confidence: 99%

Prevalence and risk factors of asymptomatic hepatitis C virus infection in Egyptian children

El-Raziky¹

2007

WJG

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AIM:To identify the prevalence, risk factors and manifestations of asymptomatic hepatitis C virus (HCV) infection in Egyptian children. METHODS:Children at the age of 1-9 years were screened for HCV antibodies and alanine aminotransferase (ALT) levels. Every child with elevated ALT and/or detectable HCV antibodies was tested for HCV RNA by RT-PCR and compared with two negative controls for risk factors and signs and symptoms of liver disease. RESULTS:We screened 1042 children, six of them had elevated ALT, negative HCV antibody and positive RNA, likely representing acute hepatitis C cases. Fifteen children were HCV seropositive, 5 of them were HCV RNA positive. Asymptomatic HCV infection was present in 2.02% (positive results for either HCV antibodies or HCV-RNA or both). Symptoms such as diarrhea, abdominal pain, history of fatigue and school absence because of illness and risk factors such as dental care were significantly more common among HCV positive cases than among controls. None of the HCV positive children was diagnosed as having signs of advanced liver disease upon clinical or ultrasonographic examination. CONCLUSION:Asymptomatic HCV infection is detectable in 2.02% Egyptian children.

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“…LATIFA T. F. YEUNG, 1 SUSAN M. KING, 2 AND EVE A. ROBERTS 1 Hepatitis C virus (HCV) infection is acquired through transfusion of infected blood or blood products or through routes not related to transfusion, classified as communityacquired disease. In developed countries, the predominant transmission route of hepatitis C is changing.…”

mentioning

confidence: 99%

Mother–To–Infant Transmission of Hepatitis C Virus

2001

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Changing epidemiologic pattern of chronic hepatitis C virus infection in Italian children

Cited by 66 publications

References 19 publications

Mother-to-Child Transmission of Hepatitis C Virus (HCV) Among HIV/HCV-Coinfected Women

Mother-to-Child Transmission of Hepatitis C Virus (HCV) Among HIV/HCV-Coinfected Women

Prevalence and risk factors of asymptomatic hepatitis C virus infection in Egyptian children

Mother–To–Infant Transmission of Hepatitis C Virus

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