Changing Concepts in the Management of Differentiated Thyroid Cancer

Intenzo, Charles; Jabbour, Serge; Dam, Hung; Capuzzi, David M.

doi:10.1053/j.semnuclmed.2005.05.003

Cited by 15 publications

(2 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…34 Surgery with or without radiotherapy remains the primary treatment modality for vertebral metastases in patients with uncontrolled back pain, progressive neurological deficit, or spinal instability. 15,24,26 Prior studies have assessed the prognostic factors associated with systemic metastasis from thyroid carcinoma; however, none have specifically investigated the factors that affect survival in patients undergoing surgery for spinal metastases. 3,5,13,16,18,21,25,32,36,39,40 Therefore, the objective of this study was to analyze a series of consecutive patients who underwent surgery for spinal metastasis from thyroid cancer in order to identify factors associated with postoperative survival and complications.…”

mentioning

confidence: 99%

Factors affecting survival in 43 consecutive patients after surgery for spinal metastases from thyroid carcinoma

Sellin

Suki

Harsh

et al. 2015

SPI

View full text Add to dashboard Cite

OBJECT Spinal metastases account for the majority of bone metastases from thyroid cancer. The objective of the current study was to analyze a series of consecutive patients undergoing spinal surgery for thyroid cancer metastases in order to identify factors that influence overall survival. METHODS The authors retrospectively reviewed the records of all patients who underwent surgery for spinal metastases from thyroid cancer between 1993 and 2010 at the University of Texas MD Anderson Cancer Center. RESULTS Forty-three patients met the study criteria. Median overall survival was 15.4 months (95% CI 2.8–27.9 months) based on the Kaplan-Meier method. The median follow-up duration for the 4 patients who were alive at the end of the study was 39.4 months (range 1.7–62.6 months). On the multivariate Cox analysis, progressive systemic disease at spine surgery and postoperative complications were associated with worse overall survival (HR 8.98 [95% CI 3.46–23.30], p < 0.001; and HR 2.86 [95% CI 1.30–6.31], p = 0.009, respectively). Additionally, preoperative neurological deficit was significantly associated with worse overall survival on the multivariate analysis (HR 3.01 [95% CI 1.34–6.79], p = 0.008). Conversely, preoperative embolization was significantly associated with improved overall survival on the multivariate analysis (HR 0.43 [95% CI 0.20–0.94], p = 0.04). Preoperative embolization and longer posterior construct length were significantly associated with fewer and greater complications, respectively, on the univariate analysis (OR 0.24 [95% CI 0.06–0.93] p = 0.04; and OR 1.24 [95% CI 1.02–1.52], p = 0.03), but not the multivariate analysis. CONCLUSIONS Progressive systemic disease, postoperative complications, and preoperative neurological deficits were significantly associated with worse overall survival, while preoperative spinal embolization was associated with improved overall survival. These factors should be taken into consideration when considering such patients for surgery. Preoperative embolization and posterior construct length significantly influenced the incidence of postoperative complications only on the univariate analysis.

show abstract

mentioning

confidence: 99%

Factors affecting survival in 43 consecutive patients after surgery for spinal metastases from thyroid carcinoma

Sellin

Suki

Harsh

et al. 2015

SPI

View full text Add to dashboard Cite

show abstract

“…Stunning, as defined, was first demonstrated in 1951 (5), and this phenomenon has subsequently been reported in numerous papers and summarized in recent reviews (6,7). An inference from the observation of stunning is that the diagnostic dosage has interfered in some way with the trapping or retention of the therapeutic dosage or that the targeted mass has been reduced in volume and, hence, in uptake.…”

Section: Discussionmentioning

confidence: 99%