Changing Aspects in the Treatment of Squamous Cell Carcinoma of the Oral Tongue

Vermund, Halvor; Jacobsen, A. B.; Kaalhus, Olav; Levernes, S.; Melsom, H; Tausjø, Johan; Thorud, E.; Thorvik, J.; Winther, Finn Ø.; Wist, Erik

doi:10.3109/02841868709091424

Cited by 11 publications

(5 citation statements)

References 17 publications

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“…In spite of this potentially negative prognostic factor (17), the treatment results in this group were slightly better, although the difference was not statistically significant due to the small number of patients. The best results concerning local control in previous studies seem to have been obtained with interstitial therapy alone ( 18) or combinations including implants (16). The degree of necrosis in the present group of implanted patients was not negligible, as 10 out of 21 patients (48%) had some kind of necrosis.…”

Section: Discussionsupporting

confidence: 47%

“…Most of these patients were treated with excision alone, and did not receive any electrive irradiation or neck dissection, and Nathanson et al (9) found a recurrence rate of 38% in another Swedish study of TINO tumours treated with excision, and several authors have shown a high percentage of conversion from NO to N + even for TI tumours (16).…”

Section: Discussionmentioning

confidence: 99%

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Prognostic Factors for Local Control and Survival of Cancer of the Oral Tongue a retrospective analysis of 230 cases in Western Sweden

1993

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Section: Discussionsupporting

confidence: 47%

Section: Discussionmentioning

confidence: 99%

Prognostic Factors for Local Control and Survival of Cancer of the Oral Tongue a retrospective analysis of 230 cases in Western Sweden

1993

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“…Surgery is generally considered the optimal treatment [6,11 , 13,181, however recent studies suggest that multimodal therapy may improve disease control [12,16]. Others feel that radiation is the treatment of choice [ 141.…”

Section: Discussionmentioning

confidence: 99%

Squamous cell carcinoma of the tongue: Experience with 86 consecutive cases

Reichard

Joseph

Cohen

et al. 1993

Journal of Surgical Oncology

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Charts from 86 patients treated for carcinoma of the tongue were reviewed to identify strategies that might improve patient outcome. Seventy-one patients (83%) were black and 69 patients (80%) were male. Overall 2- and 5-year survival rates were 20% and 12%, with stage-specific 2-year survivals of 71% (I and II, n = 7), 33% (III, n = 15), and 11% (IV, n = 64) (P < 0.01). Patients with well-differentiated tumors (n = 27) had a higher 2-year survival than that of the others (n = 53, 30% vs. 11%, P = 0.05). Six were unclassified. Twenty-three (27%) patients underwent primary surgical resection and lymphadenectomy with or without adjuvant therapy. Two-year overall and disease-free survivals were 43% and 26%, respectively. Fifty (58%) patients received radiotherapy with or without chemotherapy, achieving 2-year overall and disease-free survivals of 12% and 6% (P < 0.01). The remaining 13 patients received chemotherapy alone or no treatment and survived an average of 6 months. Distant metastasis were diagnosed in 14 patients (16%). Tongue carcinoma in this socioeconomic setting was characterized by late diagnosis and poor prognosis. Degree of tumor differentiation, disease stage, and treatment modality seemed to correlate with prognosis. Surgery, when possible, achieved superior results for disease control and survival. While cancer prevention efforts are critical, steps to identify high-risk groups to implement early detection programs may help improve outcome for these patients.

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“…Radium has not been used for head and neck cancer since 1977. In 1978 Halvor Vermund introduced the guide gutter technique for implantation of iridium 192 'hairpins' for the treatment of cancer of the oral tongue/ floor of mouth (2) and in 1985 the more flexible plastic tube technique was introduced by Erik Thorud. By this technique target volumes in the base of the tongue as well as in the velotonsillar region were reached.…”

Section: Brachytherapy Of Squamous Cell Carcinoma Of the Nasal Vestibmentioning

confidence: 99%