Changes with age in copper and superoxide dismutase levels in brains of C57BL/6J mice

Massie, Harold R.; Aiello, Valerie R.; Iodice, Arthur A.

doi:10.1016/0047-6374(79)90073-3

Cited by 75 publications

(26 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, activity of Cu-Zn SOD decreased in aged rats. These results are in agreement with those of Massie et al [21], who observed decrement in SOD activity with ageing. SOD enzymes are specific for bioconversion of 05 into H1O2 and molecular 05 to prevent the peroxidation of lipids [22].…”

Section: Discussionsupporting

confidence: 83%

Age-Related Elevation of Lipid Peroxidation Products: Diminution of Superoxide Dismutase Activity in the Central Nervous System of Rats

et al. 1991

View full text Add to dashboard Cite

Alteration in lipid peroxidation products such as lipid peroxides, lipid hydroperoxides were studied in different regions of CNS of ageing rats (13, 26, 52, 78 and 104 weeks). The levels of lipid peroxide and lipid hydroperoxide were increased in various regions of brain and spinal cord. However, the activity of superoxide dismutase was decreased in cerebrum, hypothalamus, hippocampus, cerebellum, brain stem and spinal cord. The present communication demonstrates that the different parts of CNS at 13 and 26 weeks of age have lipid peroxidation products different from that of 104-week-old rats.

show abstract

Section: Discussionsupporting

confidence: 83%

Age-Related Elevation of Lipid Peroxidation Products: Diminution of Superoxide Dismutase Activity in the Central Nervous System of Rats

et al. 1991

View full text Add to dashboard Cite

show abstract

“…In crude data, an increase in the level of these metals was found in the patient groups. Massie et al and Maynard et al in their researches reported that the Cu increases with aging in the brains of mouse models [27,28]. Maynard declared that an increase in Cu contents of human brain may also be visible [26].…”

Section: Discussionmentioning

confidence: 99%

Homocysteine, trace elements and oxidant/antioxidant status in mild cognitively impaired elderly persons: a cross-sectional study

Negahdar

Hosseini

Parsian

et al. 2015

Romanian Journal of Internal Medicine

View full text Add to dashboard Cite

Introduction. Mild cognitive impairment (MCI) is the prodromal stage of Alzheimer's disease (AD), so identification of the related risk factors can be helpful. There are controversial data regarding the serum oxidant/antioxidant status, trace elements and homocysteine (Hcy) as effective parameters in this disease, therefore the status of these factors was determined in this study.Methods. One hundred-twenty elderly persons with cognitive impairment and 120 elderly healthy persons who were differentiated using Mini-mental state examination (MMSE) participated in this study. The patients were divided into mild and moderate-to-severe cognitive impairment group. Serum antioxidant/oxidant, copper (Cu), manganese (Mn), zinc (Zn) and Hcy concentrations were measured using routine methods.Results. Oxidant and antioxidant levels increased and decreased based on the severity of the disease and were higher and lower in patients than in control group, respectively (p<0.001). With adjusting for age, gender and education, significant difference in Hcy levels was not observed. There was no significant difference in trace elements levels among groups.Conclusions. Results confirmed the association between oxidative damage with increasing the severity of cognitive impairment. These factors may be involved in the etiology of cognitive impairment and AD. Identification of such biomarkers is important to select appropriate treatment goals before the onset of irreversible clinical signs.

show abstract

“…Studies in mice and humans show that iron and copper levels increase with normal aging in several tissues, including brain (12)(13)(14)(15)(16)(17), while zinc levels either remain unchanged or show a slight decrease (14,16,18,19). Therefore, a breakdown of metal regulation could be an inevitable consequence of aging.…”

mentioning

confidence: 99%

Overexpression of Alzheimer's Disease Amyloid-β Opposes the Age-dependent Elevations of Brain Copper and Iron

Maynard¹,

Cappai²,

Volitakis³

et al. 2002

Journal of Biological Chemistry

335

308

View full text Add to dashboard Cite

Changes with age in copper and superoxide dismutase levels in brains of C57BL/6J mice

Cited by 75 publications

References 8 publications

Age-Related Elevation of Lipid Peroxidation Products: Diminution of Superoxide Dismutase Activity in the Central Nervous System of Rats

Age-Related Elevation of Lipid Peroxidation Products: Diminution of Superoxide Dismutase Activity in the Central Nervous System of Rats

Homocysteine, trace elements and oxidant/antioxidant status in mild cognitively impaired elderly persons: a cross-sectional study

Overexpression of Alzheimer's Disease Amyloid-β Opposes the Age-dependent Elevations of Brain Copper and Iron

Contact Info

Product

Resources

About