Changes to taxonomy and the International Code of Virus Classification and Nomenclature ratified by the International Committee on Taxonomy of Viruses (2018)

King, Andrew M. Q.; Lefkowitz, Elliot J.; Mushegian, Arcady; Adams, Michael J.; Dutilh, Bas E.; Gorbalenya, Alexander E.; Harrach, Balázs; Harrison, Robert L.; Junglen, Sandra; Knowles, Nick J.; Kropinski, Andrew M.; Krupovìč, Mart; Kuhn, Jens H.; Nibert, Max L.; Rubino, Luisa; Sabanadzovic, Sead; Sanfaçon, Hélène; Siddell, Stuart G.; Simmonds, Peter; Varsani, Arvind; Zerbini, F. Murilo; Davison, Andrew J.

doi:10.1007/s00705-018-3847-1

Cited by 601 publications

(215 citation statements)

References 8 publications

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“…Multicomponent genome organizations are relatively common among viruses that infect plants and fungi, but no multicomponent animal viruses have been described (Fulton, 1980; King et al, 2011). The dose-response kinetics of GCXV indicate that at least three different particles are required for plaque formation.…”

Section: Discussionmentioning

confidence: 99%

“…Differences are seen in the nature of the genetic material (single or double-stranded, positive or negative-sense, linear or circular), the number of genome segments (from 1 to 12) and the manner in which multi-segmented genomes are packaged (together or separately) (King et al, 2011). These differences can have important functional implications for key processes such as gene expression, transmission and genetic recombination.…”

Section: Introductionmentioning

confidence: 99%

“…Although multicomponent genomes are relatively common among RNA viruses that infect plants and fungi, this method of genome organization has not previously been seen in animal viruses (Fulton, 1980; King et al, 2011). This virus has tentatively been designated Guaico Culex virus (GCXV), based on the first collection location (near the Guaico community in Trinidad) and the genus of the mosquito that appears to serve as its primary host.…”

Section: Introductionmentioning

confidence: 99%

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A Multicomponent Animal Virus Isolated from Mosquitoes

Ladner

Wiley

Beitzel

et al. 2016

Cell Host & Microbe

125

176

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SUMMARY RNA viruses exhibit a variety of genome organization strategies, including multicomponent genomes in which each segment is packaged separately. While multicomponent genomes are common among viruses infecting plants and fungi, their prevalence among those infecting animals remains unclear. We characterize a multicomponent RNA virus isolated from mosquitoes, designated Guaico Culex virus (GCXV). GCXV belongs to a diverse clade of segmented viruses (Jingmenvirus) related to the prototypically unsegmented Flaviviridae. The GCXV genome comprises five segments, each of which appears to be separately packaged. The smallest segment is not required for replication, and its presence is variable in natural infections. We also describe a variant of Jingmen tick virus, another Jingmenvirus, sequenced from a Ugandan red colobus monkey, thus expanding the host range of this segmented and likely multicomponent virus group. Collectively, this study provides evidence for the existence of multicomponent animal viruses and their potential relevance for animal and human health.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Multicomponent Animal Virus Isolated from Mosquitoes

Ladner

Wiley

Beitzel

et al. 2016

Cell Host & Microbe

125

176

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“…However, our catalogue of the virosphere is in its infancy, and there are still great gains to be made from 'molecular natural history'. Fewer than 5 thousand viruses have received formal taxonomic recognition (King et al 2018) and only around 15 thousand have even been named informally ( Figure 1A). This is less comprehensive than the 17 th century view of plant diversity, even in absolute terms (ca.…”

mentioning

confidence: 99%

Expansion of the Metazoan Virosphere: Progress, Pitfalls, and Prospects

Obbard

2018

Preprint

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Metagenomic sequencing has led to a recent and rapid expansion in the animal virome. It has uncovered a multitude of new virus lineages from under-sampled host lineages, including many that break up long branches among previously known clades, and many with genomes that display unexpected sizes and structures. Although there are challenges to inferring the existence of a virus from a viruslike sequence, the analysis of nucleic acid (including small RNAs) and sequence data can give us considerable confidence in the absence of an isolate. As a consequence, this period of 'molecular natural history' is helping to reshape our views of deep virus evolution. Nevertheless, there is a limit to what metagenomic discovery alone can tell us, and some open questions will require experimental isolates.

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“…Usually their hosts are rodents, although some will also infect other mammals and humans [1, 6, 7]. First, human cardiovirus, Vilyuisk virus, was isolated in 1960 and characterized as a divergent Theiler’s virus in 1992 [8].…”

mentioning

confidence: 99%

Viral Metagenomics Revealed a Novel Cardiovirus in Feces of Wild Rats

et al. 2019

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Background/Aims: Cardiovirus is a genus of viruses belonging to the family Picornaviridae. Here, we used viral metagenomic techniques to detect the viral nucleic acid in the fecal samples from wild rats in Zhenjiang city in China. Method: Fecal samples were collected from 20 wild rats and pooled into four sample pools and then subjected to libraries construction which were then sequenced on Illumina MiSeq platform. The sequenced reads were analyzed using viral metagenomic analysis pipeline. Results: A novel cardiovirus from feces of a wild rat was identified, named amzj-2018, of which the complete genome was acquired. Phylogenetic analysis based on the complete amino acid sequence of polyprotein revealed that amzj-2018 formed a separate branch located between clusters of Saffold virus and Rat Theilovirus 1 (RTV-1). Phylogenetic analysis based on different regions of the polyproteins, including P1, P2, P3, and P2+P3, respectively, showed discordant trees, where the tree based on P3 region indicated that amzj-2018 clustered separately between Theiler’s murine encephalomyelitis virus and RTV-1. Conclusion: The complete genome of a cardiovirus was determined from the feces of wild rats which belonged to a novel type of cardiovirus based on phylogenetic analysis. Whether it is associated with disease needs further investigation.

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Changes to taxonomy and the International Code of Virus Classification and Nomenclature ratified by the International Committee on Taxonomy of Viruses (2018)

Cited by 601 publications

References 8 publications

A Multicomponent Animal Virus Isolated from Mosquitoes

A Multicomponent Animal Virus Isolated from Mosquitoes

Expansion of the Metazoan Virosphere: Progress, Pitfalls, and Prospects

Viral Metagenomics Revealed a Novel Cardiovirus in Feces of Wild Rats

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