Changes over 13 years in skin reactivity to histamine in cohorts of children aged 9–13 years

Ronchetti, R; Villa, Maria Pia; Ciofetta, G; Barreto, Mario; Falasca, Carlo; Martella, Susy

doi:10.1034/j.1398-9995.2001.056005436.x

Cited by 17 publications

(28 citation statements)

References 27 publications

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“…The small increase of the histamine wheal size may however reflect some methodological bias. An increase in skin reactivity to histamine over time has also been reported by Ronchetti et al 41, and they suggest this could be a result of increased skin cellular or neurogenic inflammation. Nevertheless, this hypothesis remains to be proved and is still not supported by others 42.…”

Section: Discussionsupporting

confidence: 65%

Major increase in allergic sensitization in schoolchildren from 1996 to 2006 in northern Sweden

Rönmark¹,

Bjerg²,

Perzanowski³

et al. 2009

Journal of Allergy and Clinical Immunology

159

221

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Background Time trends for allergic sensitization are poorly known. Aim To compare the trends in prevalence of allergic sensitization and associated risk factors in children. Methods Two cohorts of children (age 7–8 years) were invited to skin prick testing (SPT) ten years apart, 1996 and 2006. Participation rate was 2148 (88%) and 1700 (90%), respectively. The methods were identical and ten common airborne allergens were used. An expanded ISAAC-questionnaire about symptoms and possible risk factors for allergic conditions was completed by the parents. Results The prevalence of any positive SPT increased from 21% in 1996 to 30% in 2006 (p<0.001). The pattern of sensitization remained similar, and sensitization to cat was most common both years, 13% and 19%, respectively. Sensitization to mites and mould were uncommon in both surveys. A family history of allergy was a significant risk factor for a positive SPT both years (OR 1.7). Factors that in 1996 had a protective effect, i.e. rural living and having several siblings, had lost this effect in 2006. The prevalence of most risk factors remained similar, but respiratory infections and smoking among parents decreased significantly. During the same period there was no significant increase in prevalence of current wheeze (11.9% to 12.4%, n.s.) or symptoms of rhinitis or eczema. Conclusion The prevalence of allergic sensitization increased significantly from 1996 to 2006, while no increase in clinical symptoms was found. The parallel decrease in parental smoking and respiratory infections indicate a different influence of environmental factors on allergic sensitization and clinical symptoms, respectively.

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Section: Discussionsupporting

confidence: 65%

Major increase in allergic sensitization in schoolchildren from 1996 to 2006 in northern Sweden

Rönmark¹,

Bjerg²,

Perzanowski³

et al. 2009

Journal of Allergy and Clinical Immunology

159

221

View full text Add to dashboard Cite

show abstract

“…Our recent report that 3 histamine concentrations pricked in 3 subsequent cohorts of 9-year-old schoolchildren studied for 13 years elicited progressively larger wheals (+180% from 1983 to 1996, p > 0.001) [13, 14]; similar observations over 16 years [15]nevertheless show that histamine skin reactivity also undergoes environmental influences.…”

Section: Introductionmentioning

confidence: 58%

Skin Reactivity to Histamine and Codeine in Unselected 9-Year-Old Children from Italy, Poland and Libya

Ronchetti

Villa

Bohmerova

et al. 2004

Int Arch Allergy Immunol

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Background: Previous studies have shown that histamine skin reactivity (the dimensions of a skin wheal elicited by a prick with histamine 10 mg/ml) in unselected school children has increased in Italy during the past two decades and is higher in Italy than in Poland. Hence this variable can probably be influenced by a changing or different lifestyle. The aim of this study was to compare skin reactivity to histamine and codeine (a marker of histamine releasability from mast cells) in schoolchildren from countries with different lifestyles. Methods: Six previously unstudied unselected populations of 9-year-old schoolchildren (two each from Poland, Italy, and Libya; n = 863 subjects; 49.0% males) were pricked with two concentrations of histamine (10 and 1 mg/ml) and codeine (90 and 9 mg/ml). Results: The higher concentrations of both pharmacologic agents tested yielded significantly different wheal areas in the three countries: Poland < Italy < Libya (histamine, 11.8, 16.1 and 20.7 mm²; codeine, 9.2, 13.2 and 16.2 mm²; p < 0.001 for all comparisons). The lower concentrations elicited almost matching results. Histamine wheal areas correlated closely with areas elicited by codeine in the same individual: angular coefficients of the histamine to codeine regression lines were 0.535, Italy; 0.551, Libya; 0.612, Poland; and 0.581 for the whole population. More histamine was needed to produce a wheal in Poland than in Libya: a 20-mm² wheal required an injected histamine concentration of about 8.8 mg/ml in Libya, 29.5 mg/ml in Italy and 102.1 mg/ml in Poland. Conclusion: More studies are necessary to explain the observed international differences in skin histamine reactivity and their effect on the prevalence of positive allergen skin tests.

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“…the specific interaction between allergen and IgE antibodies bound to mast cell membranes and the subsequent tissue response to histamine released from mast cells themselves. Our current findings [31, 32, 36] therefore imply that HSR can no longer be considered a fixed, personal character interfering with the ‘true’ prediction of allergen responsiveness (atopy) [3, 5]. On the contrary, it should be considered a variable that in conjunction with, but independently from atopic mechanisms, determines the body response to allergen exposure.…”

Section: Discussionmentioning

confidence: 78%

Allergen skin weal/radioallergosorbent test relationship in childhood populations that differ in histamine skin reactivity: a multi‐national survey

Ronchetti

Villa

Rennerova

et al. 2005

Clin Experimental Allergy

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These findings suggest that HSR--a variable that differs in schoolchildren populations from the three countries studied--independently influences the results of ASPT and its influence should be considered when ASPT are assessed in international studies. The HSR differences found in the populations reported here probably reflect a complex, dynamic, environmental interaction that should be monitored in the different parts of the world.

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Changes over 13 years in skin reactivity to histamine in cohorts of children aged 9–13 years

Abstract: The marked time-related increase in the size of the histamine wheals could help to explain the trend toward an increased prevalence of positive allergen skin test reactions reported during the past years. The causes of increased skin reactivity to histamine remain conjectural.

Cited by 17 publications

References 27 publications

Major increase in allergic sensitization in schoolchildren from 1996 to 2006 in northern Sweden

Major increase in allergic sensitization in schoolchildren from 1996 to 2006 in northern Sweden

Skin Reactivity to Histamine and Codeine in Unselected 9-Year-Old Children from Italy, Poland and Libya

Allergen skin weal/radioallergosorbent test relationship in childhood populations that differ in histamine skin reactivity: a multi‐national survey

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