Changes on chromosome 11p15.5 as specific marker for embryonal rhabdomyosarcoma?
Ales Vicha,
Pavla Jencova,
Daniela Novakova‐Kodetova
et al.
Abstract:Rhabdomyosarcomas (RMS) constitute a heterogeneous spectrum of tumors with respect to clinical behavior and tumor morphology. The paternal uniparental disomy (pUPD) of 11p15.5 is a molecular change described mainly in embryonal RMS. In addition to LOH, UPD, the MLPA technique (ME030kit) also determines copy number variants and methylation of H19 and KCNQ1OT1 genes, which have not been systematically investigated in RMS. All 127 RMS tumors were divided by histology and PAX status into four groups, pleomorphic h… Show more
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