Changes of Weight and Hemodynamics of the Spleen Consequent of Circulatory Disturbance

Sato, Toshio; Suda, Yasuo; Koyama, Kenji; Yamauchi, Hidemi; Yamamoto, Kyoji

doi:10.1620/tjem.96.267

Cited by 6 publications

(3 citation statements)

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“…Many cases are thought to be induced not by organic injury but by the breakdown of circulatory regulation due to the dysfunction of the hypothalamo-autonomic nervous system. 4) Various tests often find no abnormalities, when the breakdown of circulatory regulation due to autonomic dysfunction occurs in patients with normal circulatory functions. Headup tilt test (HUT) 5) is one method often used to induce OH in humans for the purpose of testing OH of undetermined origin and neurally mediated syncope (NMS).…”

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Effects of Some .BETA.-Adrenoceptor Antagonists on Orthostatic Hypotension in Repeatedly Cold- (SART-) Stressed Rats

Funakami

Hata

Itoh

et al. 2007

Biological & Pharmaceutical Bulletin

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Hypotension has not been recognized as a disease and has been neglected till now, because the symptoms are quiet and rarely life-threatening unlike those of hypertension. However, many people suffer from hypotension, and these people also suffer from orthostatic hypotension (OH). While the role played by stress in hypertension is often talked about, there are nearly no reports on the relationship between hypotension and stress and that between OH and stress just like there are nearly no reports on hypotension itself. We have been studying the relationship.1,2) We receive various kinds of stress in our everyday life. Among many stressors, those we talk about daily seem to be psychological stresses arising from jobs or personal relationships. The majority of these stressors are anger and hostility, as well as suppression and anxiety. Hypotensive patients often manifest symptoms when they have these psychological factors.3) Hypotension also occurs when patients are under excessive environmental stress, such as cold and heat. Many cases are thought to be induced not by organic injury but by the breakdown of circulatory regulation due to the dysfunction of the hypothalamo-autonomic nervous system. 4)Various tests often find no abnormalities, when the breakdown of circulatory regulation due to autonomic dysfunction occurs in patients with normal circulatory functions. Headup tilt test (HUT) 5) is one method often used to induce OH in humans for the purpose of testing OH of undetermined origin and neurally mediated syncope (NMS). However, details of HUT vary by researchers, such as degree of HUT or the positive criteria of OH and NMS. The dose of isoproterenol, which is often used in HUT in order to increase the induction rate of NMS, also varies by researchers. [6][7][8][9][10][11] In the present study, the role played by the autonomic nervous system, especially b-adrenoceptors in OH was investigated by performing HUT to SART (specific alternation of rhythm in temperature) 12) -stressed rats with various symptoms of autonomic imbalance 13) and hypotension. 1) There are many people who complain of poor physical condition at a season with severe temperature changes or at a change of seasons, such as early spring or the beginning of autumn. SART-stressed animals are created in simulation of such a state by rearing in an environment where temperature changes rapidly, intermittently and repeatedly between room temperature and low temperature. 12,14) The animals are used widely in research as an autonomic imbalance model animal of systemic parasympathetic hypertonia and sympathetic hypotonia 13) based on results of, the Aschner's test, Mecholyl test and GSR (galvanic skin response) test.SART-stressed rats have been reported to have increased heart rate, 12) abnormal electrocardiogram (ECG), 15) continuous hypotension 1) and other circulatory changes. 16,17) SARTstressed rats develop OH easily when subjected to HUT.2) It has also been reported that these symptoms are improved by muscarinic M 2 -receptor antagonists. 18,19) E...

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Effects of Some .BETA.-Adrenoceptor Antagonists on Orthostatic Hypotension in Repeatedly Cold- (SART-) Stressed Rats

Funakami

Hata

Itoh

et al. 2007

Biological & Pharmaceutical Bulletin

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“…"Οσον άφορα εις τήν αίματικήν ροήν εις τον φυσιολογικόν σπλήνα κυνός οί SATO και συν. 46 το 1968 ύπελόγισαν ταύτην ϊσην προς 1. 28 κ. έκ.…”

Section: δυναμικη της κυκλοφοριαςunclassified

“…Ό Pryor 4Ι αναφέρει δτι ώς απέδειξαν ίστολογικαί μελέται του Prankerd 41 , ή παγί δευσις είναι μεγαλύτερα εις έξωκολποειδικάς θέσεις. Ό αριθμός των ερυ θρών αιμοσφαιρίων τών κατακρατουμένων εις τάς έξωκολποειδικάς θέσεις δυνατόν να είναι μεγαλύτερος του 46% του συνολικού όγκου τών ερυθρών αιμοσφαιρίων 42 , 46 .…”

Section: δυναμικη της κυκλοφοριαςunclassified

Δυναμικη Της Κατακρατησεως Των Μεταβληθεντων Δια Θερμανσεως Ραδιενεργων Ερυθρωναιμοσφαιριων Υπο Του Σπληνος Δια Της Γ-Camera Επι Παθολογικων Καταστασεων

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Bloodless splenic surgery: The safe warm-ischemic time

Teperman

Whitehouse

Sammartano

et al. 1994

Journal of Pediatric Surgery

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Changes of Weight and Hemodynamics of the Spleen Consequent of Circulatory Disturbance

Cited by 6 publications

References 0 publications

Effects of Some .BETA.-Adrenoceptor Antagonists on Orthostatic Hypotension in Repeatedly Cold- (SART-) Stressed Rats

Effects of Some .BETA.-Adrenoceptor Antagonists on Orthostatic Hypotension in Repeatedly Cold- (SART-) Stressed Rats

Δυναμικη Της Κατακρατησεως Των Μεταβληθεντων Δια Θερμανσεως Ραδιενεργων Ερυθρωναιμοσφαιριων Υπο Του Σπληνος Δια Της Γ-Camera Επι Παθολογικων Καταστασεων

Bloodless splenic surgery: The safe warm-ischemic time

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