Changes of various natural autoantibodies concentration in gestational complications

Abstract

Natural regulatory autoantibodies (immunoglobulins G) are one of the tools of the immmune system to control antigen-molecular organism homeostasis. Taking into account transplacental transfer of immunoglobulins G, determination and analysis of autoantibodies concentration during pregnancy promotes understanding of the immunopathological processes underlying normal and impaired course of gestation. The subject of autoantibodies is becoming more relevant due to the paradigm shift in modern medicine: a turn from treatment to disease prevention. The review analyzes scientific research in which the concentration of various natural autoantibodies was studied to predict such obstetrical complications as massive bleeding, fetoplacental insufficiency, preeclampsia, delayed fetal growth, and miscarriage. Studies which allow suggesting fetus’s pathological condition and perinatal pathology based оn the woman’s blood concentration of some regulatory autoantibodies are of particular interest. Autoantibodies to total myelin protein, proteins S-100 (Soluble at 100% saturation - Ca-dependent regulator of cellular functions) and MP-65 (membrane protein), double-stranded deoxyribonucleic acid, β2-glycoprotein, cardiolipin, low-density lipoproteins, total phospholipids, chorionic gonadotropin, phosphatidylserine, prothrombin, angiotensin II, membrane antigens of platelets, kidneys and liver mitochondria, nervous tissue components NF-200 (axonal specific protein), and GFAP (astrocyte filament protein), and neuron-specific enolase were the most important for pregnancy. Study and systematic analysis of the dependence of normal gestational course from the certain regulatory antibodies concentration in prregnant woman’s blood facilitate searching new methods for the earliest detection and prevention of the pathology of pregnancy and fetus.