Changes of the met-enkephalin-like peptide content induced by noxious stimuli in the rat incisor pulp

Kudo, Teruo; Chang, Huei-Ling; Maeda, Shin; Uchida, Yoshiyasu; Nakamae, Junji; Inoki, Reizo

doi:10.1016/0024-3205(83)90593-3

Cited by 19 publications

(2 citation statements)

References 4 publications

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“…The presence of some opioids, metenkephalin, ␤-endorphin, and dynorphin has been reported in normal pulps (21)(22)(23). Pulpal opioids increase after stimulation with bradykinin (24,25) and after orthodontic tooth movement (26). The most convincing evidence for the presence of peripheral analgesia in the pulp is the demonstration of opioid receptors on pulpal nerve (27).…”

mentioning

confidence: 96%

Local Opioids in the Inflamed Dental Pulp

Mudie

Holland

2006

Journal of Endodontics

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confidence: 96%

Local Opioids in the Inflamed Dental Pulp

Mudie

Holland

2006

Journal of Endodontics

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“…Recent reports (15,16) showed that an increase of metenkephalin-like peptide content in the rat incisor pulp induced by noxious stimuli was due to ac-5 Induced acute pancreatitis T Hours tivation of trypsin-like enzymes, and this increase was attenuated by a protease inhibitor (FOY-305 Gabexate mesilate). In addition, the metenkephalinlike peptide content of the pulp was much increased in the presence of bradykinin, and its release was dose-dependently increased by bradykinin (1 7).…”

Section: Discussionmentioning

confidence: 97%

Effect of a New Synthetic Protease Inhibitor on Beta-endorphin Release During Acute Pancreatitis in Dogs

Satake¹,

Hiura²,

Ha³

et al. 1991

Pancreas

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The effect on endogenous beta-endorphins of a new synthetic protease inhibitor was studied in acute pancreatitis. Pancreatitis was induced by the injection of autologous bile mixed with trypsin into the main pancreatic duct after ligation of the accessory duct. Plasma beta-endorphin concentrations and cardiovascular function were measured. Ten dogs (control group) were given 10 ml/kgh of lactate Ringer's solution intravenously beginning 1 h before the induction of pancreatitis and continuing throughout the experiments. Six dogs received an intravenous infusion of 3 mglkgh of a new synthetic protease inhibitor, E-3 123 (4-(2-succinimidoethylthio)4-geranidinobenzoate methanesulfonate), in lactate Ringer's solution soon after the induction of pancreatitis.Plasma beta-endorphin concentrations in the control group increased significantly. However, plasma beta-endorphin levels in the protease inhibitor group did not increase as in the control group. The protease inhibitor infusion improved hypotension, myocardial depression, and plasma lactate, suggesting that the inhibitory effect of the protease inhibitor on beta-endorphin release contributed to the improvement.

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