Changes of the complement system and rheological indicators after therapy with rheohemapheresis

Bláha, M.; Andrýs, Ctirad; Langrová, H; Studnička, Jan; Dršata, J; Lánska, M.; Bláha, V.; Žák, Pavel

doi:10.1016/j.atherosclerosissup.2015.02.009

Cited by 7 publications

(7 citation statements)

References 25 publications

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“…This improves blood microcirculation and may be the main pathophysiological reason why rheopheresis is effective in the treatment of SISHL. During one procedure, the level of fibrinogen is reduced by 56%, similar to the other rheological important factors which we published elsewhere [12]. One procedure reduce total blood viscosity by 15.6%.…”

Section: Discussionsupporting

confidence: 80%

“…One procedure reduce total blood viscosity by 15.6%. We maintained reduced blood viscosity by repeating the procedures 3 times [12]. …”

Section: Discussionmentioning

confidence: 99%

“…Contraindications of rheopheresis are identical to the general contraindications of hemapheresis - uncontrolled metabolic conditions (diabetes), cardiovascular disorders (unstable hypertension or coronary artery disease), malignancies, acute infections and cerebral insufficiency. Some other details have previously been described elsewhere [12, 15]. Patients with acute hearing loss underwent 3 procedures within one week.…”

Section: Study Objective and Methodsmentioning

confidence: 99%

“…alpha-2-macroglobulin, fibrinogen, LDL cholesterol, von Willebrand factor (vWF), IgM, fibronectin, putatively multimeric vitronectin), thus lowering full blood and plasma viscosity [11]. These procedures have pleiotropic effects, including favorable modifications of cytokine and adhesive molecule levels, increased production of endothelial NO, improved erythrocyte deformability and reduced aggregability of both erythrocytes and platelets [7, 12]. Improvement of perfusion in inner ear microcirculation as a result of lower blood viscosity is a possible therapeutic approach in patients with SISHL.…”

Section: Introductionmentioning

confidence: 99%

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Rheopheresis in treatment of idiopathic sensorineural sudden hearing loss

Košťál

Dršata

Bláha

et al. 2017

J of Otolaryngol - Head & Neck Surg

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BackroundOnly few therapeutic options exist for patients with refractory sudden idiopathic sensorineural hearing loss (SISHL). Little is known about the efficacy of second-line therapies. Rheopheresis seems to be an effective therapeutic possibility.MethodsBetween 2012 and 2015, 106 patients with SISHL were enrolled in the study, of whom 52 were refractory to initial treatment. As salvage therapy, these patients were offered either 3 sessions of rheopheresis (33 pts) or intratympanic steroid treatment through MicroWick application (19 pts). Pure tone audiometry was performed at diagnosis, at the 1st month and the 1st year during the follow-up.ResultsPatients in the rheopheretic arm had higher hearing loss than in the MicroWick arm (81% vs. 52%, p = 0.04). In spite of this, there was a significant improvement for patients in the rheopheretic arm (27% of hearing loss reduction, p < 0.001) after the 1st month and this remained unchanged during the 1st year, while no improvement was seen in the MicroWick arm (0% of hearing loss reduction, p = 0.424). We found no predictive factor for steroid-failure in first-line therapy. Older age (p = 0.003), presence of vertigo (p = 0.006) and more profound initial hearing loss (p < 0.001) were identified as negative prognostic markers.ConclusionRheopheresis can be used as a potentially effective and safe salvage therapy for patients with cortico-refractory SISHL.

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Section: Discussionsupporting

confidence: 80%

“…One procedure reduce total blood viscosity by 15.6%. We maintained reduced blood viscosity by repeating the procedures 3 times [12]. …”

Section: Discussionmentioning

confidence: 99%

Section: Study Objective and Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Rheopheresis in treatment of idiopathic sensorineural sudden hearing loss

Košťál

Dršata

Bláha

et al. 2017

J of Otolaryngol - Head & Neck Surg

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“…Rh is considered to exert a rapid effect on a number of indicated conditions with symptoms due to seriously affected microcirculation and rheologic parameters such as, the dry age-related macular degeneration (AMD), sudden sensorineural hearing loss (SSHL), peripheral artery disease (PAD), calciphylaxis, systemic sclerosis, and diabetic foot. 6,7…”

Section: Introductionmentioning

confidence: 99%

Rheopheresis: A narrative review

Kosmadakis

2022

Int J Artif Organs

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Introduction: Rheopheresis is an extracorporal selective double-filtration procedure with an initial separation of plasma from the whole blood and a further filtration of the plasma through a second filter in order to eliminate a certain number of high molecular weight proteins such LDL, Lp(a), fibrinogen, α2-macroglobulin, Factor von Willebrand, and IgM Immunoglobulin. Methods: In this narrative review we discuss the available data on the effects of Rheopheresis in various clinical conditions. Results: Rheopheresis is considerd to exert a rapid effect on clinical conditions associated with seriously affected microcirculation and rheologic parameters such as, the dry age-related macular degeneration (AMD), sudden sensorineural hearing loss (SSHS), peripheral artery disease (PAD), calciphylaxis, systemic sclerosis and diabetic foot. Conclusions: Rheopheresis is a promising technique for conditions associated with affected microcirculatory rheologic parameters

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