Changes of Th17 cells, regulatory T cells, Treg/Th17, IL-17 and IL-10 in patients with type 2 diabetes mellitus: a systematic review and meta-analysis

Zi, Changyan; He, Liyun; Yao, Huan; Ren, Yuan; He, Tingting; Gao, Yongxiang

doi:10.1007/s12020-022-03043-6

Cited by 15 publications

(16 citation statements)

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“…The DM group showed a higher prevalence of hypertension and hyperlipidaemia and a corresponding medication history than the controls; this finding is consistent with the epidemiological characteristics of DM (Glovaci et al, 2019). The with diabetes increase, whereas the level of Treg cells decreases (Zi et al, 2022). OLP is a chronic inflammation mediated by T cells.…”

Section: Discussionmentioning

confidence: 99%

“…Insulin resistance and pancreatic β‐cell dysfunction caused by chronic low‐level inflammation and immune response are important factors in the development and progression of T2DM (Böni‐Schnetzler & Meier, 2019; Brooks‐Worrell & Palmer, 2019). Compared with those in non‐diabetic patients, the levels of Th17 cells and IL‐17 in the peripheral blood of patients with diabetes increase, whereas the level of Treg cells decreases (Zi et al, 2022). OLP is a chronic inflammation mediated by T cells.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of oral lichen planus in patients with diabetes mellitus: A cross‐sectional study

et al. 2022

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ObjectivesOral lichen planus, a chronic inflammatory immune disease, occurs in the oral mucosa. We aimed to assess the prevalence and possible influencing factors of oral lichen planus in patients with diabetes mellitus.Subjects and MethodsThis cross‐sectional study involved 525 patients with diabetes mellitus and 525 controls. We collected information on blood glucose level, duration of diabetes, diabetic complications, treatment methods, other systemic diseases and medication history.ResultsOral lichen planus was significantly more prevalent in the diabetes mellitus/type 2 diabetes mellitus group than in the controls (2.3%/2.2% vs. 0.6%, p = 0.019/0.022). There was no significant association between patients with diabetes mellitus with and those without oral lichen planus in age (p = 0.195), sex (p = 0.390), blood glucose level (p = 1), duration of diabetes (p = 0.638), diabetic complications (p = 1), treatment methods (p = 0.962), other systemic diseases (p = 0.891) and medication history (p = 0.848).ConclusionsDiabetes mellitus was associated with oral lichen planus; there was a higher prevalence of oral lichen planus in patients with diabetes mellitus/type 2 diabetes mellitus than in those without diabetes. Oral lichen planus development in patients with diabetes mellitus was not significantly associated with age, sex, blood glucose level, duration of diabetes, diabetic complications, treatment methods, other systemic diseases and medication history.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prevalence of oral lichen planus in patients with diabetes mellitus: A cross‐sectional study

et al. 2022

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“…Fourth, because the meta-analysis provided pooled results from cross-sectional studies, it remained unknown whether the increase in circulating IL concentrations was causally related (as a cause or consequence) to T2DM development. Many researchers have attempted to reveal this relationship by investigating IL concentrations in various types of cells or tissues from which ILs originate (58,59). But there is limited evidence available from a longitudinal perspective, with one exemplary dataset that estimated serum IL-1Ra concentrations longitudinally from years before diagnosis through the conclusion of follow-up (61), suggesting preventive and therapeutic value of investigating IL-blocking agents.…”

Section: Discussionmentioning

confidence: 99%

Increased circulating interleukin concentrations in type 2 diabetes mellitus: A systematic review and meta-analysis

Cao,

Yuan,

Gilbert

et al. 2024

Preprint

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BACKGROUND Chronic systemic inflammation links to type 2 diabetes mellitus (T2DM) onset, and the potential role of interleukins in this pathogenic process is increasingly recognized. PURPOSE To quantitatively evaluate circulating interleukin concentrations data available for T2DM patients. DATA SOURCES We performed a systematic review using PubMed, Web of Science, and the Cochrane Library. STUDY SELECTION Original studies reporting data on circulating interleukin concentrations in at least one group of T2DM patients [obese T2DM, overweight T2DM, or lean T2DM] and healthy weight controls (HWCs) were included. DATA EXTRACTION AND SYNTHESIS Data were extracted from 43 included studies uniquely encompassing 2,646 T2DM patients and 6,605 HWCs by independent investigators. We used a random-effects model to pool data in the Comprehensive Meta-Analysis Version 2 software. Effect sizes were calculated as the standardized mean difference in interleukin concentrations between groups and then transformed into Hedge's g statistic. LIMITATIONS Of the ILs included in the analysis (interleukin 2, 4, 6, 8, 10, 12, 17, 18, 22, and 33), 70% were with a high level of between-study heterogeneity and could not be fully accounted for by factors such as BMI, sex, age, and publication year. More studies are warranted to identify more contributing clinical variables. CONCLUSIONS Meta-analysis outcomes demonstrated higher circulating concentrations of IL-4, IL-6, IL-17, and IL-18 in T2DM patients, strengthening the clinical evidence that T2DM is accompanied by a systemic inflammatory response.

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“…Previously, there was no information about an increase in the content of this cellular subpopulation in patients with T2DM. At the same time, it has been shown that patients with T2DM are characterized by a decrease in the relative content of CD4+CD25+FOXP3+ Treg cells [12]. Another group of researchers found that Treg lymphocyte content decreases with a duration of T2DM of more than 10 years [13].…”

Section: Discussionmentioning

confidence: 99%

Pilot study of the FoxP3+ T lymphocyte count and its relationship with the Gensini score in patients with coronary heart disease and type 2 diabetes mellitus from a South American cohort

Estévez Gómez,

Acevedo Peña,

Castillo Goyeneche

et al. 2023

Preprint

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INTRODUCTIONOne of the pathogenic links between type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD) is low-intensity chronic inflammation, which is limited by FoxP3+ regulatory T cells.MATERIALS AND METHODSA comparative, observational, single-center, single-stage study was carried out. The severity of atherosclerosis was assessed by calculating the Gensini score based on selective coronary angiography. The absolute and relative content of CD4+CD25 high FoxP3+ and CD4+CD25 low FoxP3+ T cells in the blood was evaluated by flow cytometry.RESULTS57 patients with chronic ischemic heart disease were examined. Patients with a combination of CHF and T2DM are characterized by an increase in the relative and absolute content of FoxP3+CD25 lymphocytes in the peripheral blood and an increase in the intranuclear content of FoxP3 in them, which is more pronounced in patients with disease moderate. atherosclerosis (Gensini score 17 to 45 points).CONCLUSIONSThis was the first Latin American study that managed to show the relationship between an increase in the content of low FoxP3+CD25 lymphocytes in the peripheral blood with atherosclerosis in patients with a combination of coronary artery disease and DM2.

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Changes of Th17 cells, regulatory T cells, Treg/Th17, IL-17 and IL-10 in patients with type 2 diabetes mellitus: a systematic review and meta-analysis

Cited by 15 publications

References 58 publications

Prevalence of oral lichen planus in patients with diabetes mellitus: A cross‐sectional study

Prevalence of oral lichen planus in patients with diabetes mellitus: A cross‐sectional study

Increased circulating interleukin concentrations in type 2 diabetes mellitus: A systematic review and meta-analysis

Pilot study of the FoxP3+ T lymphocyte count and its relationship with the Gensini score in patients with coronary heart disease and type 2 diabetes mellitus from a South American cohort

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