Changes of Tangential Traction after Macular Peeling: Correlation between <i>en-face</i> Analysis and Macular Sensitivity

Romano, Mario R.; Cennamo, Gilda; Cesarano, Ida; Cardone, Domenico; Nicoletti, Giuseppe; Mastropasqua, Rodolfo

doi:10.1080/02713683.2016.1231322

Cited by 15 publications

(13 citation statements)

References 46 publications

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“…Structural outcomes have been well reported in literature in terms of reduced macular thickness after ERM/ILM peeling in patients affected by iERMs [ 11 , 27 ]. We found a statistically significant reduction of CMT in both groups.…”

Section: Discussionmentioning

confidence: 99%

Intraretinal changes in idiopathic versus diabetic epiretinal membranes after macular peeling

et al. 2018

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IntroductionEpiretinal traction is not responsible only for epiretinal but also intraretinal changes. This study aims to describe structural and vascular intraretinal changes after macular peeling in idiopathic (iERM) vs diabetic ERM (dERM).MethodsWe conducted a prospective interventional study on forty-two eyes, 23 with iERMs and 19 with dERMs, undergoing ERM-ILM peeling. We performed SD-OCT preoperatively, 1 and 6 months postoperatively to assess central macular thickness (CMT), intraretinal cysts (IC) and/or continuous ectopic inner foveal layers (CEIFL), superficial and deep capillary free zone (CFZ) area on OCT-A. Glial fibrillary acidic protein (GFAP), as a Müller cells marker, was detected immunohistochemically on ILM specimens, to assess Müller cells iatrogenic damage.ResultsThe CEIFLs were significantly more common in iERMs (12 (52.2%) in iERMs vs 2 (10.5%) in dERMs, p = 0.004), whereas ICs in dERMs (6 (26.1%) in iERMs vs 17 (89.5%) in dERMs, p<0.001). Median preoperative and postoperative BCVA was 20/50 [20/40-20/66] and 20/33 [20/25-20/40] in iERMs and 20/100 [20/66-20/200] and 20/50 [20/50-20/66] in dERMs, respectively. Median preoperative and postoperative CMT was 423 [370–488] and 364 [329–382] μm in iERM group and 465 [447–503] and 378 [359–433] μm in dERM group, respectively. The BCVA improvement and reduction of CMT thickness were significant in both groups (p<0.001). The presence of CEIFL was associated with lower BCVA in iERMs. Deep CFZ network significantly increased only in dERMs, passing from 0.34 [0.29–0.42] mm2 preoperatively to 0.56 [0.46–0.6] mm2 at 6-month follow-up (p<0.001). The GFAP expression was significantly higher in dERMs (p = 0.001).ConclusionThe intraretinal changes are different in iERMs and dERMs, as increased expression of CEIFLs in iERMs vs ICs in dERMs. The CEIFLs are associated with worse anatomical and functional outcomes in iERMs, whereas GFAP espression in peeled ILMs is higher in dERMs.

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Section: Discussionmentioning

confidence: 99%

Intraretinal changes in idiopathic versus diabetic epiretinal membranes after macular peeling

et al. 2018

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“…It has been shown by Romano et al 18,19 that deep retinal changes can occur as a result of ERM and that these changes are correlated to functional outcomes. Although isolating specific intra-retinal phenomenon was not our current aim, a general effect on deep layer thickness is clearly seen.…”

Section: Discussionmentioning

confidence: 99%

Retinal layers thickness changes following epiretinal membrane surgery

Hecht

Yeshurun

Bartov

et al. 2017

Eye

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PurposeTo evaluate the time course of changes in the thickness of retinal layers after epiretinal membrane (ERM) removal surgery.MethodsA retrospective cohort study of patients following surgery for idiopathic ERM. We used new specialized image analysis software to create a thickness map of each retinal layer and analyzed changes during one year follow-up. Healthy fellow eyes were used as negative controls and the retina prior to surgery as positive control.ResultsTwenty-one patients were included with a mean age of 68±13 years. Central macular thickness decreased steadily until 6 months after surgery (25% decrease, 516±76 to 386±73 μm, P<0.001) with no further decrease between 6 and 12 months (386±73 to 390±73 μm, P=0.291). The retinal nerve fiber layer (RNFL), and the ganglion cell and inner plexiform layer (GCIPL) were most affected (57%, P<0.001 and 27%, P=0.010, respectively). The thickest region showed a more abrupt decrease of 21% at first follow-up (504±61 to 399±58 μm, P=0.001) with subsequent decrements of about 3%. Prior to surgery all retinal layers were thicker in study eyes compared with healthy control eyes (6-63%, all P<0.05).ConclusionsFollowing ERM surgery, in the course of 6 months, the macula gradually becomes thinner after which a stable state is reached. All layers appear to be affected, with the RNFL and GCIPL impacted the most. Our results provide a unique view on how the thickness of different retinal layers changes following ERM surgery.

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“…Reduction in macular thickness after surgical treatment of ERM have been well reported in previous studies. 9,10 We found substantial reduction in the mean central foveal thickness in both groups after surgery. The ectopic inner foveal layers persisted post surgically in all the eyes but the thickness of EIFL reduced.…”

Section: Discussionmentioning

confidence: 68%

Anatomical and functional significance of ectopic inner foveal layer (EIFL) in epiretinal membrane (ERM)

Ganekal

Ganekal²

2021

IJCEO

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To compare the visual acuity outcomes after surgical treatment of epiretinal membranes (ERM) in cases with and without ectopic inner foveal layers (EIFL). : A total of 100 eyes of 98 patients with idiopathic ERM were retrospectively staged according to the newer OCT classification and divided into two groups on the basis of presence or absence of EIFL. The two groups were evaluated for various parameters including visual acuity, thickness of the EIFL, re-appearance of the foveal contour, outer retinal changes and complications before and after ERM peeling. Correlation analysis was done using chi square test and p-values were obtained for corresponding variables.: Of 100 eyes with ERM, 20% had stage 1, 29% had stage 2, 42% had stage3 & 9% had stage 4 disease. VA was worse in eyes with EIFL as compared those without it. Correlation of VA with EIFL thickness however was not significant. Surgical removal of ERM didn’t alter EIFL frequency though the thickness decreased. New EIFL appeared in 4% eyes and 35% demonstrated thickened fovea after surgery. Anatomical reappearance of foveal contour was poorer in eyes with EIFL. Outer retinal changes were more common in non EIFL eyes. Lamellar holes and nontractional cysts were more common in EIFL eyes.: EIFL is a significant prognostic tool to predict the visual outcome of surgery in cases of Epiretinal membrane. EIFL eyes did not regain foveal contour, had less outer retinal damage but were associated with poorer visual outcomes.

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Changes of Tangential Traction after Macular Peeling: Correlation between en-face Analysis and Macular Sensitivity

Cited by 15 publications

References 46 publications

Intraretinal changes in idiopathic versus diabetic epiretinal membranes after macular peeling

Intraretinal changes in idiopathic versus diabetic epiretinal membranes after macular peeling

Retinal layers thickness changes following epiretinal membrane surgery

Anatomical and functional significance of ectopic inner foveal layer (EIFL) in epiretinal membrane (ERM)

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