Changes of serum zinc-α2-glycoprotein level and analysis of its related factors in gestational diabetes mellitus:a cross-sectional study

Abstract

Background Previous studies have discovered that zinc-α2-glycoprotein is related to insulin resistance and lipid metabolism. The aim of the study is to explore the change of serum zinc-α2-glycoprotein(ZAG) and its related factors in gestational diabetes mellitus(GDM). Methods Eighty newly diagnosed GDM patients were enrolled in study group, and 80 normal pregnant women were selected as control group. The differences of baseline data between the two groups were compared, and the change of serum ZAG level and its relationship with related indexes was analyzed. Results Compared to control group, the level of serum ZAG in the study group decreased [(43.94 ± 14.51)mg/L vs. (62.57 ± 19.05)mg/L, P < 0.001]. Pearson correlation (or Spearman correlation) analysis showed that serum ZAG level was negatively correlated with FPG, FINS, HOMA-IR and TG (P < 0.05) and positively correlated with HDL(P < 0.05). Multiple linear regression showed that HDL, FINS, HOMA-IR were independent factors of serum ZAG(P < 0.001). Conclusion The level of serum ZAG in patients with gestational diabetes mellitus decreased, and HDL, FINS and HOMA-IR are the influencing factors in study group. Trial registration: The study registered in the Chinese Clinical Trial Registry(Chi CTR2000028811).

Association of Serum Zinc Levels and Some Risk Factors with Gestational Diabetes Mellitus in Women Referred to the Diabetes Clinic of Bu-Ali Hospital of Zahedan in 2021

“…Feng et al reported serum zinc levels of 43.9 ± 14.5 and 62.5 ± 19.0 mg/L in pregnant women with GDM and controls, respectively (P < 0.001). Also, in this study, there was a significant relationship between serum zinc levels and indices such as gestational age (P < 0.03), diastolic blood pressure (P < 0.001), height, and insulin resistance (P < 0.001), which was in line with the findings of another study (18). In Mishu et al's study, serum zinc levels were significantly lower in GDM women compared to healthy pregnant women, who had normal glucose levels in the second and third trimesters of pregnancy.…”

“…Wang et al showed that the mean level of serum zinc in pregnant women with BMIs less than 18 kg/m 2 was lower than in peers with normal BMIs (15). Variabilities in the findings of these studies can be due to different factors, including different cut-off points used to define zinc deficiency, age differences between the studied populations, as well as variations in economic status, gestational age, and the sample size (18).…”