Changes of serum total cholesterol and triglyceride levels in normal subjects in Japan in the past twenty years.

Sekimoto, Hiroshi; Gotō, Yoshio; Goto, Yuichiro; Naito, Chikayuki; Yasugi, Tadao; Okido, M; Kuzuya, Fumio; Takeda, Ryoyu; Yamamoto, Akira; Fukuzaki, Hisashi; Kajiyama, Goro; Kokubu, Tatsuo; Uzawa, Haruo; Mimura, Goro; Shimada, Osafumi

doi:10.1253/jcj.47.1351

Cited by 68 publications

(22 citation statements)

References 8 publications

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“…The TG level seemed to be higher in females at 5-14 years and in males above 15 years of age. The TG levels in the present study tended to be higher than those for North Americans (66-144 and 75-125 mg/ 100 ml, 10-59 years, for males and females, respectively) [12], Japanese (81-126 and 89-112 mg/ 100 ml, 10-59 years, for males and females, respectively) [ 11 ] , males in the United States of America (90 mg/100 ml, 21-58 years) [16], and young people in Venezuela (72 and 78 mg/ 100 ml, 8-15 years, for males and females, respectively) [17]. One of the reasons for the high TG levels in the serum of the Nepalese may be a low intake of polyunsaturated fatty acids, which acids normally inhibit the synthesis of TG in situ in the cell.…”

Section: Methodscontrasting

confidence: 59%

“…The mean level of Chol tended to be higher for males than for females above 30 years of age. In published epidemiological studies, serum Chol levels generally increased throughout adulthood, reaching a plateau at approximately the sixth decade of life [11][12][13]. The results from our present survey on Chol showed the highest level at 40-49 years for both sexes.…”

Section: Methodssupporting

confidence: 58%

“…One of the reasons for the highest Chol level at 40-49 years instead of at 60 years may be short life expectancy at birth of Nepalese (44 years in 1980 estimate) [14]. The Chol levels found in Nepal appear to be lower than the values for India (118-182 and 150-185 mg/ 100 ml, 11-65 years, for males and females, respectively) [15], those of Indians in the United States of America (158-198 and 149-188 mg/ 100 ml, 10-54 years, respectively) [13], those of Japanese (159-199 and 171-211 mg/ 100 ml, 10-59 years, respectively) [ 11], and those of North Americans (158-214 and 160-231 mg/ 100 ml, 10-59 years, respectively) [12]. The mean TG level for males was 106-87 mg/ 100 ml for ages 1-14 years and increased to 157 mg/ 100 ml for ages 15-19 years (Table 2).…”

Section: Methodsmentioning

confidence: 99%

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Nutritional survey on the serum status of lipid, protein, and calcium levels in Nepalese.

Hirai

Okuno

Nagata

et al. 1990

J. Clin. Biochem. Nutr.

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SummaryThis study examined the physical status (72 males and 69 females) and serum distribution of lipids, protein, and Ca (60 males and 57 females) of people aged 1 to 72 years living in southeastern Nepal. The mean values of height and weight increased with age to adolescence and were the same for both sexes in childhood. Males were taller than females above the 15-19-year age group. There were large weight differences among individuals, with adult males tending to be heavier than adult females. The average body mass index increased with age (r=0.72, p < 0.001), and there were no significant differences between the sexes. The levels of body mass index were positively correlated with weight (r = 0.92, p<0.001) and with serum levels of cholesterol and triglycerides (r=0.43, and r = 0.38, p<0.001, respectively). The levels of serum lipids were about the same for both sexes in childhood and tended to be higher for males than for females in adulthood.Serum levels of cholesterol, phospholipids, and total lipids were positively correlated with age (r=0.46, r=0.36, and r = 0.37, p<0.001, respectively). A direct relationship was

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Section: Methodscontrasting

confidence: 59%

Section: Methodssupporting

confidence: 58%

Section: Methodsmentioning

confidence: 99%

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Nutritional survey on the serum status of lipid, protein, and calcium levels in Nepalese.

Hirai

Okuno

Nagata

et al. 1990

J. Clin. Biochem. Nutr.

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“…In contrast, Japanese have relatively lower average serum cholesterol values, and a correspondingly lower incidence of CHD than in Western populations [4][5][6] . However, nutritional lifestyles have led to an increased intake of western-style diet with relatively high fat and high cholesterol contents which has gradually increased serum cholesterol levels in Japanese populations [7][8][9][10] . Serum lipid levels are associated with not only diet but environmental variables, such as drinking, exercise and smoking frequencies, and genetic factors.…”

mentioning

confidence: 99%

Differential Effects of Aging, Drinking and Exercise on Serum Cholesterol Levels Dependent on the PPARA‐V227A Polymorphism

Naito

Kamijima

Yamanoshita

et al. 2007

Journal of Occupational Health

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Differential Effects of Aging, Drinking andExercise on Serum Cholesterol Levels Dependent on the PPARA-V227A Polymorphism: Hisao NAITO, e t a l . D e p a r t m e n t o f O c c u p a t i o n a l a n d Environmental Health, Nagoya University Graduate School of Medicine-Peroxisome proliferatoractivated receptor α (PPAR α) plays a pivotal role in lipid metabolism. Our previous study reported that PPARA-V227A was a major polymorphism in Japanese, which was associated with markedly lower serum total cholesterol (TC) levels, which were significantly affected by alcohol drinking compared to subjects with the wild-type (PPARA-WT) allele. However, serum lipids are also associated with aging and exercise frequency. The objective of the present study was to evaluate the relationship between PPARA-V227A and these factors. Genetic analysis of the polymorphism was performed in 1058 Japanese men and 281 women, and the relationship with aging, drinking and exercise on serum lipids was analyzed in 989 men and 245 women after exclusion criteria had been applied. In men, drinking increased high-density lipoprotein cholesterol (HDL-C) levels in both PPARA-WT and A227 carriers, but to a significantly higher degree in the latter. In women, TC and low-density lipoprotein cholesterol (LDL-C) levels in the A227 carriers drinking at least once a week were significantly higher than in PPARA-WT carriers. TC and LDL-C levels in males with PPARA-WT increased with aging regardless of drinking habit, while LDL-C levels in the A227 drinking carriers were significantly lower in 45-yr-old or older subjects than in 35-to 45-yr-olds. In addition, no effect of exercising was observed in the A227 carriers, while increase in the HDL-C of the PPARA-WT carriers was exercise frequency dependent. These results suggest that the influence of drinking, aging or exercise on TC, LDL-C and HDL-C levels in the A227 carriers may be different from those in the PPARA-WT subjects. (J Occup Health 2007; 49: 353-362)

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“…Average dietary fat intake has been doubled in Japan in these 20 years, and serum total cholesterol (TC) levels, especially of youth, seem to have approached to the levels of Europeans and Americans (Sekimoto et al 1983). As there are few reports of determination of serum lipids in Japanese and foreign youth at the same laboratories, we compared serum TC and high density lipoprotein cholesterol (HDLC) between overseas and Japanese university students.…”

mentioning

confidence: 99%

Total cholesterol, high density lipoprotein cholesterol and choline esterase in overseas and Japanese university students.

Nakamura

1985

Tohoku J. Exp. Med.

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Changes of serum total cholesterol and triglyceride levels in normal subjects in Japan in the past twenty years.

Cited by 68 publications

References 8 publications

Nutritional survey on the serum status of lipid, protein, and calcium levels in Nepalese.

Nutritional survey on the serum status of lipid, protein, and calcium levels in Nepalese.

Differential Effects of Aging, Drinking and Exercise on Serum Cholesterol Levels Dependent on the PPARA‐V227A Polymorphism

Total cholesterol, high density lipoprotein cholesterol and choline esterase in overseas and Japanese university students.

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