Changes of Serum Selenium in Pregnant Women with Gestational Diabetes Mellitus

Tan, Minghong; Sheng, LiQin; Yine, Qian; Ge, Yongxin; Yingsong, Wang; Zhang, Hongde; Mingli, Jiang; Zhang, Guilin

doi:10.1385/bter:83:3:231

Cited by 51 publications

(55 citation statements)

References 7 publications

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“…Our study showed that the selenium level of gestational diabetes and intolerant pregnancies was lower than that of normal pregnant women. The results were similar to the reports of previous researches [5][6][7][8]. The results from both studies demonstrated that selenium is a very important element for glucose intolerants, and its deficiency could aggravate diabetes in the gestational period and increase diabetic complications.…”

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

Evaluation of Serum Selenium Levels in Turkish Women with Gestational Diabetes Mellitus, Glucose Intolerants, and Normal Controls

Kılınç

Güven

Ezer

et al. 2008

Biol Trace Elem Res

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The aim of the study was to investigate the association between serum selenium levels in patients with gestational diabetes mellitus (GDM) and glucose intolerants and compare them with those of glucose-tolerant pregnant women. This cross-sectional study was prospectively performed in a total of 178 pregnant women undergoing a 50-g oral glucose tolerance test between 24 and 28 weeks of gestation who were grouped according to their status of glucose tolerance as with gestational diabetes (group A, abnormal 1- and 3-h glucose tolerance test; n = 30), glucose intolerant (group B, abnormal 1-h but normal 3-h glucose tolerance test; n = 47), or normal controls (group C, normal 1-h glucose test; n = 101). Serum selenium levels were measured with a graphite furnace atomic absorption spectrophotometer using a matrix modifier. Median maternal age and gestational age at the time of diagnosis in group A (gestational age = 24.8 [24-27]), group B (gestational age = 24.7 [24-27]), and group C (gestational age = 25 [24-28]) did not differ. Patients with gestational diabetes mellitus and those with glucose intolerants had lower selenium level than that of the normal pregnant women (P< 0.001). There was a significant inverse correlation between selenium and blood glucose level, and also selenium supplementation might prove beneficial on patients with GDM and prevent or retard them from secondary complications of diabetes.

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Section: Discussionsupporting

confidence: 90%

“…These decreases are greater in pregnant women with gestational or pre-existing diabetes. A lower level of selenium has been described in GDM, and it has been shown that there was a inverse relationship with this trace element status and glucose tolerance [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Serum Selenium Levels in Turkish Women with Gestational Diabetes Mellitus, Glucose Intolerants, and Normal Controls

Kılınç

Güven

Ezer

et al. 2008

Biol Trace Elem Res

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“…Many epidemiological studies demonstrated that serum Se levels were lower in diabetic patients than in healthy individuals. [17][18][19] The atrophy and degeneration of pancreatic islets have also been reported in patients with the Se-deficiency syndrome, Keshan disease.…”

Section: )mentioning

confidence: 91%

Effects of Administering Sodium Selenite, Methylseleninic Acid, and Seleno-L-methionine on Glucose Tolerance in a Streptozotocin/Nicotinamide-Induced Diabetic Mouse Model

Ueno

Shimizu

Okuno

et al. 2014

Biological & Pharmaceutical Bulletin

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The effects of administering the selenocompounds, sodium selenite, methylseleninic acid (MSA), and seleno-L-methionine (SeMet) on glucose tolerance were compared in the nicotinamide (NA) and streptozotocin (STZ)-induced diabetic mouse model. ICR mice were intraperitoneally treated twice with STZ (100 mg/ kg) 15 min after an injection of NA (120 mg/kg) at a 1-d interval. Non-fasting blood glucose levels were then monitored weekly while orally administering the selenocompounds at 158 µg Se/kg body weight with free access to a selenium-deficient diet for 5 weeks. The mean body weights of NA/STZ-induced diabetic mice were partly restored by the administration of selenocompounds, while SeMet led to a higher selenium content and glutathione peroxidase 1 activity in the pancreas. Non-fasting and oral glucose tolerance-tested blood glucose levels, which were elevated by NA/STZ, were significantly suppressed by the administration of SeMet. These results suggest that SeMet may improve glucose tolerance in a NA/STZ-induced mild diabetic mouse model by increasing bioavailability in the pancreas.

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“…Many epidemiological studies have proved that serum Se levels in diabetic patients are lower than the levels in healthy individuals. [14][15][16][17][18] The atrophy and degeneration of pancreatic islets are observed in patients with a Se deficiency syndrome, Keshan disease. 19) Se-insufficient rats have low serum insulin levels, which are normalized by Se-supplementation.…”

Section: Introductionmentioning

confidence: 99%

Effect of Sodium Selenite Supplementation on Glucose Intolerance and Pancreatic Oxidative Stress in Type 2 Diabetic Mice under Different Selenium Status

Shimizu

Ueno

Okuno

et al. 2009

JOURNAL OF HEALTH SCIENCE

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The objective of this study was to investigate the effect of various selenium (Se) status on glucose intolerance and pancreatic oxidative stress or the defense systems in Nagoya-Shibata-Yasuda (NSY) mice as the animal model for type 2 diabetes mellitus. To let the mice become Se-insufficient to Se-sufficient conditions, the NSY mice were given normal or Se-deficient diet with 0-7.0 mg/l Na 2 SeO 3 -containing drinking water for 6, 8 or 12 weeks. In NSY mice ingested normal diet, levels of blood glucose and plasma insulin after intraperitoneal glucose tolerance test (IPGTT) were not significantly affected by Na 2 SeO 3 -supplementation. In Se-deficient diet-treatment groups, however, the supplementation resulted in the decrease of blood glucose and the increase of plasma insulin after IPGTT. Although glutathione peroxidase (GPX) 1 activity in pancreas of the NSY mice ingested Se-deficient diet was augmented by Na 2 SeO 3 -supplementation, pancreatic glutathione was depressed by the supplementation, accompanying by the increase of 2-thiobarbituric acid-reactive substances. These results indicated that although the supplemented Na 2 SeO 3 may not protect against oxidative stress in the pancreas of NSY mice under Se-insufficient condition, the Se compound improved glucose intolerance of the mice.

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Changes of Serum Selenium in Pregnant Women with Gestational Diabetes Mellitus

Cited by 51 publications

References 7 publications

Evaluation of Serum Selenium Levels in Turkish Women with Gestational Diabetes Mellitus, Glucose Intolerants, and Normal Controls

Evaluation of Serum Selenium Levels in Turkish Women with Gestational Diabetes Mellitus, Glucose Intolerants, and Normal Controls

Effects of Administering Sodium Selenite, Methylseleninic Acid, and Seleno-L-methionine on Glucose Tolerance in a Streptozotocin/Nicotinamide-Induced Diabetic Mouse Model

Effect of Sodium Selenite Supplementation on Glucose Intolerance and Pancreatic Oxidative Stress in Type 2 Diabetic Mice under Different Selenium Status

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