Changes of serum cytokines-related Th1/Th2/Th17 concentration in patients with postmenopausal osteoporosis

Zhang, Jing; Fu, Qin; Ren, Zhaozhou; Wang, Yanjun; Wang, Chenchen; Shen, Tao; Wang, Guangbin; Wu, Lina

doi:10.3109/09513590.2014.975683

Cited by 67 publications

(53 citation statements)

References 46 publications

(42 reference statements)

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“…The change in circulating IL-17 level in the context of estrogen deprivation was frequently reported in animal studies [18] . Our study observed a significant rise in circulating IL-17 level in osteoporotic postmenopausal women, which was consistent with recent findings [19,25,26] . IL-17 can directly promote the production of RANKL by osteoblasts [17,18,27,28] .…”

Section: Discussionsupporting

confidence: 82%

Upregulated Cellular Expression of IL-17 by CD4+ T-Cells in Osteoporotic Postmenopausal Women

Zhao

Xin-zheng

Feng³

2016

Ann Nutr Metab

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Aim: The study aimed to investigate cellular expression of IL-17 by CD4+ T-cells in osteoporotic postmenopausal women. Methods: We enrolled 25 postmenopausal women with osteoporosis (PostMO) and 25 postmenopausal women with normal bone mineral density measurements (PostM) to examine the production of IL-17, tumor necrosis factor a (TNFa) and receptor activator of nuclear factor γ-B ligand (RANKL) by CD4+ T-cells and IL-17, RORγt, TNFa and RANKL mRNA levels in CD4+ T-cells. Circulating concentrations of IL-17 along with IL-6, TNFa, RANKL and osteoprotegerin (OPG) were also determined. Results: Osteoporotic postmenopausal women had higher serum concentrations of IL-17 (3.7 ± 1.3 vs. 2.5 ± 1.1 ng/ml, p = 0.042), IL-6 (158 ± 56 vs. 105 ± 39 pg/ml, p = 0.044), TNFa (138 ± 41 vs. 74 ± 11 pg/ml, p < 0.001) and OPG (1.7 ± 0.4 vs. 1.3 ± 0.4 ng/ml, p = 0.039) than healthy controls. The IL-17-producing CD4+ T-cells were higher in the PostMO group than in the PostM group (7.1 ± 2.4 vs. 4.9 ± 1.4%, p = 0.0015). Additionally, osteoporotic postmenopausal women had greater mRNA levels of IL-17 (3.5 ± 2.9 vs. 1.2 ± 1.0%, p = 0.019) and RORγt (5.7 ± 2.5 vs. 2.2 ± 1.0%, p < 0.001) in CD4+ T-cells than in healthy controls. Conclusions: Our findings implied that the upregulated production of IL-17 may play an important role in regulating bone loss in osteoporotic postmenopausal women.

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Section: Discussionsupporting

confidence: 82%

Upregulated Cellular Expression of IL-17 by CD4+ T-Cells in Osteoporotic Postmenopausal Women

Zhao

Xin-zheng

Feng³

2016

Ann Nutr Metab

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“…Another factor responsible for the bone loss induced by estrogen deficiency is IL-17, the signature cytokine of Th17 cells (47), which are an osteoclastogenic subset of CD4 + T cells (45,46). Intriguingly, postmenopausal women with osteoporosis exhibit elevated levels of serum IL-17 (66)(67)(68). In mice, ovx expands Th17 cells by promoting the differentiation of naive CD4 + T cells into mature Th17 cells (69), a phenomenon driven by cytokines such as TGFβ, IL-6, IL-1β, and TNF (43,44,47,70) -factors that are all disregulated by estrogen deficiency (25).…”

Section: Discussionmentioning

confidence: 99%

Sex steroid deficiency–associated bone loss is microbiota dependent and prevented by probiotics

Li¹,

Chassaing²,

Tyagi³

et al. 2016

Journal of Clinical Investigation

473

610

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“…Due to the function of adipose tissue as an endocrine gland which secretes several cytokines, this association has frequently been attributed to central obesity (3). Indeed, some studies have regarded inflammation as a risk factor for osteoporosis (4,5). However, the precise mechanism underlying the role of inflammation as well as the association between obesity, inflammation and osteoporosis has not yet been clarified.…”

Section: Introductionmentioning

confidence: 99%

Progranulin concentration in relation to bone mineral density among obese individuals

Milajerdi¹,

Maghbooli²,

Mohammadi³

et al. 2018

Archives of Endocrinology and Metabolism

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Objective: Adipose tissue, particularly visceral adipose tissue, secretes a variety of cytokines, among which progranulin is a glycoprotein related to the immune system. Along with other secreted proteins, progranulin may be associated with bone mineral density. The aim of this study was to find out whether there are associations between the progranulin and bone mineral density among obese people. Subjects and methods: This cross-sectional study was conducted on 244 obese participants (aged 22-52). Serum progranulin, high sensitive C-reactive protein, oxidised-low dencity lipoprotein, tumor necrosis factor-α, parathormone, vitamin D, and interleukins of 1 β, 4, 6, 10, 13, and 17 concentrations were measured. Anthropometric measurements, body composition and bone mineral density were also assessed. Results: Serum progranulin was directly associated with interleukin-6 and interleukin-1β, while it had a negative association with interleukin-17 and tumor necrosis factor-α. We also observed a statistically significant direct association between progranulin concentration and visceral fat, abdominal fat, waist, abdominal and hip circumferences, hip T-score, and Z-score and T-score for the lumbar region. A partial correlation test has also shown a significant positive correlation regarding serum progranulin and the hip Z-score. Moreover, progranulin level is inversely associated with ospteopenia (P = 0.04 and CI: 0.17,0.96 ). Conclusion: Our study revealed that central obesity may be related to increased progranulin concentration. In addition, progranulin concentration was directly related to bone formation parameters, which indicates the protective effects of progranulin on bone density. Further studies are needed to clarify the exact mechanisms underlying these associations. Arch Endocrinol Metab. 2018;62(2):179-86

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Changes of serum cytokines-related Th1/Th2/Th17 concentration in patients with postmenopausal osteoporosis

Cited by 67 publications

References 46 publications

Upregulated Cellular Expression of IL-17 by CD4+ T-Cells in Osteoporotic Postmenopausal Women

Upregulated Cellular Expression of IL-17 by CD4+ T-Cells in Osteoporotic Postmenopausal Women

Sex steroid deficiency–associated bone loss is microbiota dependent and prevented by probiotics

Progranulin concentration in relation to bone mineral density among obese individuals

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