Changes of psychiatric parameters and their relationships by oral isotretinoin in acne patients

Hahm, Bong Jin; Min, Sangkee; Yoon, Mi Young; Shin, Yong-Won; Kim, Jin Sook; Jung, Ji Ye; Suh, Dae Hun

doi:10.1111/j.1346-8138.2009.00635.x

Cited by 63 publications

(50 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, the majority of patients reported good QoL (69.2%), with no significant gender differences. This result was generally more favorable than those seen in several previous studies that reported a significantly greater impact from skin disease 22. This discrepancy may be explained by biases in questionnaire responses or cultural differences in the skin disease experience and perception of disability.…”

Section: Discussioncontrasting

confidence: 52%

Quality of life in patients with skin diseases in central Saudi Arabia

Abolfotouh¹,

Alkhowailed²,

Suliman³

et al. 2012

IJGM

View full text Add to dashboard Cite

BackgroundPrevious national and international studies of quality of life (QoL) in patients with skin diseases have revealed different levels of QoL impairment. The aims of this study were to assess QoL in patients with skin diseases in central Saudi Arabia using the newly validated Skindex-16 instrument and to determine the association between QoL in patients with skin disease, sociodemographic data, and disease characteristics.MethodsA cross-sectional study was conducted in 283 adult patients who visited the outpatient dermatology clinics of King Abdulaziz Medical City, Riyadh, Saudi Arabia, over 3 months. The patients were interviewed using a pretested Arabic version of the Skindex-16 to measure the effect of skin disorders on their QoL during the previous 7 days. Patient characteristics, medical history, and clinical findings were collected. Multiple linear regression analyses were used to relate the demographic and clinical characteristics to the percentage mean QoL score, and P ≤ 0.05 was considered to be statistically significant.ResultsQoL was good in 69% of the respondents, with a total percent mean score of 31.80 ± 20.16. The emotional domain was the most affected (mean percentage score 44.27 ± 27.06), followed by symptoms (31.45 ± 28.40) and functioning (14.61 ± 22.75). After adjustment for potential confounders, poorer QoL was significantly associated with female gender (P = 0.03), older age (P = 0.003), rural origin (P = 0.03), positive family history of the same lesion(s) (P = 0.01), shorter duration of ≤6 months (P = 0.02), generalized spread (P ≤ 0.02), and lack of isotretinoin treatment (P = 0.02).Conclusion. The QoL results in this study were generally more optimistic than those of many previous studies. This discrepancy may be due to biases in questionnaire responses or to cultural differences in experience of skin disease and perception of disability. Significant predictors of QoL were not the same for the three domains of the Skindex scale. Further studies of specific diseases and educational programs targeting patients at higher risk for QoL impairments are recommended.

show abstract

Section: Discussioncontrasting

confidence: 52%

Quality of life in patients with skin diseases in central Saudi Arabia

Abolfotouh¹,

Alkhowailed²,

Suliman³

et al. 2012

IJGM

View full text Add to dashboard Cite

show abstract

“…5 In several prospective studies, treatment with isotretinoin has been shown to improve patients with acne emotionally and psychologically. [12][13][14][15][16][17] However, these studies were probably too small to detect negative events with incidences in the order of 1-2 per 1000 person years. Many studies have shown that acne in itself has a negative psychological impact.…”

Section: Discussionmentioning

confidence: 99%

“…[12][13][14][15][16] Acne in itself is not considered to be a serious condition. If its treatment is suspected to entail severe side effects, the harm-benefit balance of that treatment must be thoroughly investigated.…”

Section: Introductionmentioning

confidence: 99%

Association of suicide attempts with acne and treatment with isotretinoin: retrospective Swedish cohort study

Sundström

Alfredsson

Sjölin‐Forsberg

et al. 2010

BMJ

165

122

View full text Add to dashboard Cite

An increased risk of attempted suicide was apparent up to six months after the end of treatment with isotretinoin, which motivates a close monitoring of patients for suicidal behaviour for up to a year after treatment has ended. However, the risk of attempted suicide was already rising before treatment, so an additional risk due to the isotretinoin treatment cannot be established. As patients with a history of suicide attempts before treatment made new attempts to a lesser extent than did patients who started such behaviour in connection with treatment, patients with severe acne should not automatically have isotretinoin treatment withheld because of a history of attempted suicide.

show abstract

“…7 75 Psychological effects improve with treatment. 76 Furthermore, acne may cause permanent scarring that is difficult to correct. Finally, because of its frequency and chronicity, the economic burden of acne is substantial, with associated expenditure in the US alone exceeding $2.5bn (£1.64bn; €1.93bn) annually.…”

Section: Oral Antibioticsmentioning

confidence: 99%