Changes of Protein Metabolism in Liver and Skeletal Muscle following Trauma Complicated by Sepsis

Effect of Fluid Infusion on Alterations in Metabolite Levels in Carbohydrate and Protein Metabolism of Septic Rats

“…The features of alterations in free amino acid levels found in the present investigation were similar to those reported in trauma and sepsis [30][31][32]. The timecourse of changes in plasma amino acid levels in both septic groups also resembled that reported in endotoxernic rabbits [33].…”

Protein Metabolism in Different Types of Skeletal Muscle During Early and Late Sepsis in Rats

“…In previous studies, protein synthesis in muscle was reported to be increased,4"6 unchanged,7 or decreased8, 9,32 following injury and sepsis. In the present study, no signifi¬ cant changes in protein synthesis were found.…”

Infusion of tumor necrosis factor/cachectin promotes muscle catabolism in the rat. A synergistic effect with interleukin 1.

“…Increased muscle catabolism is an important component of the metabolic response to acute and chronic inflammatory processes accompanying infections, trauma, tissue injury, and cancer cachexia (14,30,31). Although this has been linked to changes in several hormones, such as corticosteroids (32), catecholamines (3), and growth and thyroid hormones (33), emphasis has recently been placed on secretory peptides derived from inflammatory cells.…”