Changes of platelet function during exercise in ischemic heart disease.

Abstract

To investigate the role of platelet in ischemic heart disease, plasma levels of 3-thromboglobulin (pTG) and thromboxane B2 (TXB2) were measured in 12 normal subjects and 18 patients with effort angina pectoris (EAP), 14 with vasospastic angina pectoris (VSA), 31 with old myocardial infarction (OMI). Levels of 3TG and TXB2 were monitored before, during and after an ergometer exercise. 1) Plasma 3TG levels at rest were significantly elevated in the patients with EAP and with OMI, compared to that in normal subjects (p<0.05).2) During ergometer exercise, plasma , QTG levels were significantly (p<0.05) increased in the cases of EAP, especially in the cases having significant ST depression, and chest pain at maximal exercise.3) TXB2 levels changed during exercise neither in the normal nor in the patients with ischemic heart disease.4) At rest, platelet aggregation by collagen were decreased in the cases with EAP, VSA and with OMI.5) There were no significant changes in TXB2 production by arachidonate and