Changes of Pharmacokinetics and Metabolism of Sulfadimidine in Endotoxin Pretreated Rabbits

Saprotrophic bacteria as a possible means of controlling the immune status of the body through regulation of metabolic reactions

“…The strategy of microbial control over immunity in subjects with different acetylation phenotypes implies that, in order to stimulate immune reactions, fast acetylators, who are refractory to immunization with antigens, should be administered with acetylation inhibitors (such as E. coli LPS [20]). We believe that inhibition of acetylation in such subjects will be effective in overcoming the refractory state of their immune system.…”

“…Changes induced in the acetylation rate by Prodigiosan and E. coli LPS were tested, respectively, with slowly [17] and rapidly [20] acetylating rabbits. Activation of immune processes was observed in humans (in response to Prodigiosan [18,19]) and in mice (in response to E. coli LPS [20]) with undetermined acetylation phenotypes.…”

“…Changes induced in the acetylation rate by Prodigiosan and E. coli LPS were tested, respectively, with slowly [17] and rapidly [20] acetylating rabbits. Activation of immune processes was observed in humans (in response to Prodigiosan [18,19]) and in mice (in response to E. coli LPS [20]) with undetermined acetylation phenotypes. We suggest that a search for a correlation between the acetylation phenotype and the immunity should be carried out with animals of the above strains with known phenotypes, as well as with rapidly acetylating rats and C57BL/6 mice and with slowly acetylating rats and A/J mice [2].…”

“…Effects on the immune system 1) test subject 2) changes in the pharmacokinetics of test substances 3) changes in N-AT activity test subject 2) immunological changes 3) Prodigiosan [17][18][19] S. typhimurium [16] Rapidly and slowly acetylating rats (groups 1 and 2, respectively) infected for other notes and abbreviations, see Table 1. 400 µg [20] and increased resistance to K. pneumoniae when administered to mice at 0.001, 0.01, or 0.1 µg (which corresponds to rabbit doses of 0.1, 1, and 10 µg, which are 40 times, or 1.4 orders of magnitude, lower than the doses inhibiting acetylation) [9]. In rats with experimental salmonellosis, an increase in acetylation in antigen-binding lymphocytes was accompanied by an increase in their count [16], which proves the correlation between acetylation and immunity-related processes.…”

“…It is impossible to compare the effects on acetylation for Prodigiosan, E. coli LPS, and S. typhimurium because initial amounts of bacterial formulations were indicated in microliters of their solutions [17], micrograms [20], or microbial bodies per animal [16]. Furthermore, Prodigiosan and LPS were tested with animals differing in acetylation phenotype and exerted opposite effects on acetylation.…”