Changes of Peritoneal Transport Parameters with Time on Dialysis: Assessment with Sequential Peritoneal Equilibration Test

Waniewski, Jacek; Antosiewicz, Stefan; Baczyński, Daniel; Poleszczuk, Jan; Pietribiasi, Mauro; Lindholm, Bengt; Wańkowicz, Z

doi:10.5301/ijao.5000622

Cited by 8 publications

(2 citation statements)

References 40 publications

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“…The values of global, effective parameters for PTS, approximated from local parameters of both transport barriers, remained in agreement with previous studies that applied a membrane approach (Supplementary data, Table S1) [22][23][24][25][26]. We found that HDR patients had decreased fluid solutes penetration depths, decreased peritoneal hydraulic conductance and increased solutes peritoneal membrane diffusive coefficients, whereas in patients from HAR group, these changes were not so much pronounced, Supplementary data, Table S1, as reported by others [2,27].…”

Section: Peritoneal Transportsupporting

confidence: 88%

Alterations of peritoneal transport characteristics in dialysis patients with ultrafiltration failure: tissue and capillary components

Stachowska-Piętka

Poleszczuk

Flessner

et al. 2018

Nephrology Dialysis Transplantation

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Background Ultrafiltration failure (UFF) in peritoneal dialysis (PD) patients is due to altered peritoneal transport properties leading to reduced capacity to remove excess water. Here, with the aim to establish the role of local alterations of the two major transport barriers, peritoneal tissue and capillary wall, we investigate changes in overall peritoneal transport characteristics in UFF patients in relation to corresponding local alterations of peritoneal tissue and capillary wall transport properties. Methods Six-hour dwell studies using 3.86% glucose solutions and radioisotopically labelled serum albumin added to dialysate as a volume marker were analysed in 31 continuous ambulatory PD patients, 20 with normal ultrafiltration (NUF) and 11 with UFF. For each patient, the physiologically based parameters were evaluated for both transport barriers using the spatially distributed approach based on the individual intraperitoneal profiles of volume and concentrations of glucose, sodium, urea and creatinine. Results UFF patients as compared with NUF patients had increased solute diffusivity in both barriers, peritoneal tissue and capillary wall, decreased tissue hydraulic conductivity and increased local lymphatic absorption and functional decrease in the fraction of the ultra-small pores. This resulted in altered distribution of fluid and solutes in the peritoneal tissue, and decreased penetration depths of fluid and solutes into the tissue in UFF patients. Conclusions Mathematical modelling using a spatially distributed approach for the description of clinical data suggests that alterations both in the capillary wall and in the tissue barrier contribute to UFF through their effect on transport and distribution of solutes and fluid within the tissue.

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Section: Peritoneal Transportsupporting

confidence: 88%

Alterations of peritoneal transport characteristics in dialysis patients with ultrafiltration failure: tissue and capillary components

Stachowska-Piętka

Poleszczuk

Flessner

et al. 2018

Nephrology Dialysis Transplantation

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“…All these above-mentioned changes in peritoneum permeability are thought to result from the impairment of free water transport and ultrafiltration abilities due to defected water channel protein, aquaporin 1 (AQP1) on both endothelium and mesothelium upon the occurrence of peritoneum fibrosis [15,16]; moreover, Piccapane et al showed functional AQP1 was crucial for transmesothelial water transport. Another study also demonstrated that AQP1-containing exosomes present in peritoneal dialysis effluent may potentially serve as a biomarker for the integrity of the peritoneum, and reflect the water permeability status of the peritoneum; more importantly, detection of those AQP1-containing exosomes may be used to predict ultrafiltration failure in PD patients [17][18][19]; however, although the changes shown on PET and impairment of AQP1 were considered as relevant indications to fibrosis and angiogenesis, the underlying mechanism of these functional changes on peritoneum remains to be elucidated [20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress-Induced Alterations of Cellular Localization and Expression of Aquaporin 1 Lead to Defected Water Transport upon Peritoneal Fibrosis

Wei

Cheng

et al. 2022

Biomedicines

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Being one of the renal replacement therapies, peritoneal dialysis (PD) maintains around 15% of end-stage kidney disease patients’ lives; however, complications such as peritoneal fibrosis and ultrafiltration failure during long-term PD compromise its application. Previously, we established a sodium hypochlorite (NaClO)-induced peritoneal fibrosis porcine model, which helped to bridge the rodent model toward pre-clinical human peritoneal fibrosis research. In this study, the peritoneal equilibration test (PET) was established to evaluate instant functional changes in the peritoneum in the pig model. Similar to observations from long-term PD patients, increasing small solutes transport and loss of sodium sieving were observed. Mechanistic investigation from both in vivo and in vitro data suggested that disruption of cytoskeleton induced by excessive reactive oxygen species defected intracellular transport of aquaporin 1, this likely resulted in the disappearance of sodium sieving upon PET. Functional interference of aquaporin 1 on free water transport would result in PD failure in patients.

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Automatic Control and Feedback Loops in Biology and Medicine

Śmieja¹

2019

Advances in Intelligent Systems and Computing

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Changes of Peritoneal Transport Parameters with Time on Dialysis: Assessment with Sequential Peritoneal Equilibration Test

Cited by 8 publications

References 40 publications

Alterations of peritoneal transport characteristics in dialysis patients with ultrafiltration failure: tissue and capillary components

Alterations of peritoneal transport characteristics in dialysis patients with ultrafiltration failure: tissue and capillary components

Oxidative Stress-Induced Alterations of Cellular Localization and Expression of Aquaporin 1 Lead to Defected Water Transport upon Peritoneal Fibrosis

Automatic Control and Feedback Loops in Biology and Medicine

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