2002
DOI: 10.1267/ahc.35.113
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Changes of Osteopontin Distribution and Matrix Mineralization during Remodeling in Experimental Bone Formation.

Abstract: When bone is rapidly induced by recombinant human bone morphogenetic protein-2 (rhBMP-2), more noncollagenous proteins (NCPs) are accommodated among the collagen meshwork. These NCPs are then removed, resulting in highly mineralized mature bone. However, few reports have focused on changes in the bone matrix of rhBMP-2-induced bone. In the present study, rhBMP-2 with an artificial carrier was implanted over bone defects in rat calvariae, and changes in the distribution of osteopontin (OPN), the degree of miner… Show more

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Cited by 4 publications
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