Changes of myocardial capillary density in progression of experimental lung emphysema

Sulkowski, Stanisław; Musiatowicz, B; Sulkowska, M; Sobaniec-Łotowska, M; Dzięcioł, J; Sulik, M; Szynaka, B

doi:10.1016/s0940-2993(96)80087-x

Cited by 4 publications

(4 citation statements)

References 15 publications

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“…In this study, the animals of the Papain Group presented with mean alveolar diameters of between 101.71 and 124.02 µm, statistically different to the Control Group. Other authors also found similar values to our findings [4,8,9]. These data demonstrate that, in the lungs of animals submitted to the action of papain, there was a significant increase in the alveolar spaces consequent to the rupture of interalveolar septa.…”

Section: Commentssupporting

confidence: 92%

“…A similar pattern was observed in hamsters after the spraying of papain or pancreatic elastase verifying the significant progression of emphysema between 1 and 2 months after exposure, followed by stabilization of the histologic injury [10]. Other authors have stated that the injury stabilizes in about the third month after the initial exposure to papain [8,9]. MARTORANA et al [7] observed that the alterations in the pulmonary structure seen after the administration of papain are progressive over a few weeks and after stabilize, with no differences observed in dogs between 3 and 6 months after the induction of the emphysema.…”

Section: Commentssupporting

confidence: 70%

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Avaliação das alterações morfológicas cardíacas secundárias ao enfisema pulmonar: estudo experimental em ratos

Monteiro

Jatene

Pazetti

et al. 2004

Rev Bras Cir Cardiovasc

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Abstract:Objective: The purpose of this study is to evaluate the occurrence and repercussions of chemically induced pulmonary emphysema and the morphological alterations present in rats' hearts of post-induction and to follow the progression afterwards.Method: Seventy five rats divided into two groups: papain (N=50) and control (N=25), were submitted to intratracheal spraying of papain and saline solution, respectively, and were evaluated. The animals were sacrificed 30, 60, 90, 120 or 180 days post-spraying. Arterial blood gases and cardiac and pulmonary morphometrical analysis were performed.Results: Papain spraying produced alveolar tissue destruction similar to the morphological alterations observed in pulmonary emphysema. The papain group presented mean alveolar diameter higher than controls in all periods evaluated (p<0.05). Right ventricle wall thickness and interventricular septum did not show significant macroscopic alterations until six months after emphysema induction. The right ventricle area presented enlargement 120 days after induction of pulmonary emphysema, with mean area higher than controls at 120 and 180 days (p=0.001). The left ventricle presented significant cavity area decrease 90 days after induction of the pulmonary emphysema, followed by slight wall thickening.Conclusions: The adopted experimental model was efficient to morphologically induce pulmonary emphysema. The presence of pulmonary emphysema did not provoke morphological changes in the right ventricle wall and interventricular septum. The alveolar destruction induced left ventricular hypertrophy and enlargement of the right ventricle.Descriptors: Pulmonary emphysema, chemically induced. Pulmonary emphysema, physiopathology. Papain, pharmacology. Disease models, animal. Heart ventricle, anatomy & histology.Avaliação das alterações morfológicas cardíacas secundárias ao enfisema pulmonar: estudo experimental em ratos Evaluation of the cardiac morphological alterations secondary to the pulmonary emphysema: experimental study in rats 342 MONTEIRO, R ET AL -Evaluation of the cardiac morphological alterations secondary to the pulmonary emphysema: experimental study in rats Braz

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Section: Commentssupporting

confidence: 92%

Section: Commentssupporting

confidence: 70%

Avaliação das alterações morfológicas cardíacas secundárias ao enfisema pulmonar: estudo experimental em ratos

Monteiro

Jatene

Pazetti

et al. 2004

Rev Bras Cir Cardiovasc

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“…Hypoxia-induced angiogenesis is not a phenomena restricted to the brain. Exposure to hypoxia causes an increase in capillary density in the myocardium (40,61,66). Hypoxia-induced angiogenesis is well known as a crucial step in growth and progression of tumors (17), and it plays a role in the patho-physiology of several disease entities like rheumatoid arthritis (62) and diabetic retinopathy (36).…”

Section: R1110mentioning

confidence: 99%

Effect of chronic continuous or intermittent hypoxia and reoxygenation on cerebral capillary density and myelination

Kanaan¹,

Farahani²,

Douglas³

et al. 2006

American Journal of Physiology-Regulatory, Integrative and Comp

117

104

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Chronic hypoxia, whether continuous (CCH) or intermittent (CIH), occurs in many neonatal pathological conditions, such as bronchopulmonary dysplasia and obstructive sleep apnea. In this study, we explored the effect of CCH and CIH on cerebral capillary density and myelination. We subjected CD-1 mice starting at postnatal day 2 to either CCH 11% oxygen (O(2)), or CIH 11% O(2) (4-min cycles), for periods of 2 and 4 wk followed by reoxygenation for 4 wk. Mice were deeply anesthetized and perfused. Brains were removed to fixative for 24 h, then paraffin-embedded. Coronal brain sections were taken for analysis. Immunocytochemistry for glucose transporter 1 was used to assess angiogenesis, and Luxol fast blue and fluoromyelin stains were used to assess myelination. Capillary density increased after 2-wk exposure to CIH and CCH. By 4 wk, capillary density increased in both CIH and CCH by 25% and 47%, respectively, in cortex and by 29% and 44%, respectively, in hippocampus (P < 0.05). There was a decrease in myelination in the corpus callosum of mice exposed to CIH (75% of control) and CCH (50% of control) (P < 0.05). Reoxygenation reversed the increased capillary density seen in CCH to normoxic values. However, dysmyelination that occurred in CCH-exposed mice did not show any improvement upon reoxygenation. We conclude that neonatal chronic hypoxia 1) induces brain angiogenesis, which is reversible with reoxygenation, and 2) irreversibly reduces the extent of myelination in the corpus callosum. This potential irreversible effect on myelination in early life can, therefore, have long-term and devastating effects.

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“…Furthermore, previous animal study demonstrated that prolonged hypoxia due to emphysema induces a reduction in capillary density in the heart, suggestive of the microvascular dysfunction in the heart. 28 Recent large, population-based cohort study by Harris et al demonstrated in human subjects free of clinical cardiovascular disease that spirometrically defined low lung function was associated with microvascular changes in the retina, kidneys, and heart, and emphysema was associated with impaired stress myocardial blood flow determined by quantitative analysis of adenosine stress perfusion CMR. 29 These findings suggest that lung dysfunction may contribute to systemic microvascular disease, or that there may be a shared predisposition.…”

Section: Discussionmentioning

confidence: 99%

Associating the Severity of Emphysema with Coronary Flow Reserve and Left Atrial Conduit Function for the Emphysema Patients with Known or Suspected Coronary Artery Disease

et al. 2024

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Purpose: Pulmonary emphysema may associate with ischemic heart disease through systemic microvascular abnormality as a common pathway. Stress cardiovascular MR (CMR) allows for the assessment of global coronary flow reserve (CFR). The purpose of this study was to evaluate the association between the emphysema severity and the multiple MRI parameters in the emphysema patients with known or suspected coronary artery disease (CAD).Methods: A total of 210 patients with known or suspected CAD who underwent both 3.0T CMR including cine CMR, stress and rest perfusion CMR, stress and rest phase-contrast (PC) cine CMR of coronary sinus, and late gadolinium enhancement (LGE) CMR, and lung CT within 6 months were studied. Global CFR, volumes and functions of both ventricles and atria, and presence or absence of myocardial ischemia and infarction were evaluated. Emphysema severity was visually determined on lung CT by Goddard method.Result: Seventy nine (71.0 ± 7.9 years, 75 male) of 210 patients with known or suspected CAD had emphysema on lung CT. Goddard score was significantly correlated with CFR (r = -0.246, P = 0.029), left ventricular end-diastolic volume index (LV EDVI) (r = -0.230, P = 0.041), right ventricular systolic volume index (RV SVI) (r = -0.280, P = 0.012), left atrial (LA) total emptying volume index (r = -0.269, P = 0.017), LA passive emptying volume index (r = -0.309, P = 0.006), LA systolic strain (Es) (r = -0.244, P = 0.030), and LA conduit strain (Ee) (r = -0.285, P = 0.011) in the patients with emphysema. Multiple linear regression analysis revealed LA conduit function was independently associated with emphysema severity as determined by Goddard method (beta = -0.361, P = 0.006). Conclusion:LA conduit function independently associates with emphysema severity in the emphysema patients with known or suspected CAD after adjusting age, sex, smoking, and the CMR indexes including CFR. These findings suggest that impairment of LA function predominantly occurs prior to the reduction of the CFR in the emphysema patients with known or suspected CAD.

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Changes of myocardial capillary density in progression of experimental lung emphysema

Cited by 4 publications

References 15 publications

Avaliação das alterações morfológicas cardíacas secundárias ao enfisema pulmonar: estudo experimental em ratos

Avaliação das alterações morfológicas cardíacas secundárias ao enfisema pulmonar: estudo experimental em ratos

Effect of chronic continuous or intermittent hypoxia and reoxygenation on cerebral capillary density and myelination

Associating the Severity of Emphysema with Coronary Flow Reserve and Left Atrial Conduit Function for the Emphysema Patients with Known or Suspected Coronary Artery Disease

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