Changes of Metabolic Connectivity in Dementia with Lewy Bodies with Visual Hallucinations: A <sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography/Magnetic Resonance Study

Zorzi, Giovanni; Cecchin, Diego; Bussè, Cinzia; Perini, Giulia; Corbetta, Maurizio; Cagnin, Annachiara

doi:10.1089/brain.2020.0988

Cited by 5 publications

(4 citation statements)

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“…A normal hypometabolism in the temporoparietal cortex is specific for the absence of AD pathology [168] 6 In lvPPA, hypometabolism has been reported in the right medial temporal and posterior cingulate gyri, the left inferior, middle and superior temporal lobes, and left supramarginal gyrus [169]. Hypometabolic changes have been found to be more lateralized to the left hemisphere in amyloid PET-negative patients and more bilateral in amyloid PET-positive patients [170] 7 Occipital hypometabolism in DLB is associated with visual hallucinations [171] 8 Hypometabolism of posterior cingulate cortex can occur in FTD [172] Brain region AD 1 already mentioned DLB [32]. Typical topographic patterns of cortical and subcortical changes in glucose metabolism of parkinsonian conditions are presented in Table 2, including PD.…”

Section: Common Indicationsmentioning

confidence: 99%

EANM procedure guidelines for brain PET imaging using [18F]FDG, version 3

Guedj

Varrone

Boellaard

et al. 2021

Eur J Nucl Med Mol Imaging

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The present procedural guidelines summarize the current views of the EANM Neuro-Imaging Committee (NIC). The purpose of these guidelines is to assist nuclear medicine practitioners in making recommendations, performing, interpreting, and reporting results of [18F]FDG-PET imaging of the brain. The aim is to help achieve a high-quality standard of [18F]FDG brain imaging and to further increase the diagnostic impact of this technique in neurological, neurosurgical, and psychiatric practice. The present document replaces a former version of the guidelines that have been published in 2009. These new guidelines include an update in the light of advances in PET technology such as the introduction of digital PET and hybrid PET/MR systems, advances in individual PET semiquantitative analysis, and current broadening clinical indications (e.g., for encephalitis and brain lymphoma). Further insight has also become available about hyperglycemia effects in patients who undergo brain [18F]FDG-PET. Accordingly, the patient preparation procedure has been updated. Finally, most typical brain patterns of metabolic changes are summarized for neurodegenerative diseases. The present guidelines are specifically intended to present information related to the European practice. The information provided should be taken in the context of local conditions and regulations.

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Section: Common Indicationsmentioning

confidence: 99%

EANM procedure guidelines for brain PET imaging using [18F]FDG, version 3

Guedj

Varrone

Boellaard

et al. 2021

Eur J Nucl Med Mol Imaging

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“…Decreased activation was demonstrated in visual area V5/MT in response to the presentation of visual objects during functional MRI in patients with DLB (31). Visual hallucinations in DLB also correlated with lower glucose metabolism and weaker metabolic connectivity in the parietal-occipital cortex (32). Therefore, visuoperceptual and visuospatial functions that may be dependent upon these cortices were disproportionately impaired in patients with DLB.…”

Section: Figurementioning

confidence: 94%

The gesture imitation test in dementia with Lewy bodies and Alzheimer's disease dementia

Shen

Han

et al. 2022

Front. Neurol.

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ObjectivesDementia with Lewy bodies (DLB) is the second most common type of neurodegenerative dementia following Alzheimer's disease dementia (ADD). This study investigated the diagnostic role of the gesture imitation test in detecting DLB and differentiating DLB from ADD.MethodsA total of 63 patients with DLB, 93 patients with ADD, and 88 healthy controls were included in this study. All participants were administered the gesture imitation test, the Mini-Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA), the clock drawing test (CDT), and other neuropsychological tests.ResultsThe patients with DLB performed worse than the healthy controls in the global scores and on every item of the gesture imitation test (p < 0.001). The area under the curve (AUC) for the global scores was 0.889 (p < 0.001) in differentiating the DLB and control groups. Item 4 was a better discriminator, with a sensitivity of 79.37% and a specificity of 79.55%. The AUC for the global scores decreased to 0.593 and the difference was marginal (p = 0.079) in differentiating the DLB and ADD groups. The patients with DLB performed worse on Items 1 and 4 compared with the patients with ADD (p = 0.040, 0.004). The gesture imitation test was positively correlated with the scores of the MMSE (r = 0.355, p = 0.017), the MoCA (r = 0.382, p = 0.010), and the CDT (r = 0.407, p = 0.005) in patients with DLB.ConclusionThe gesture imitation test is an easy, rapid tool for detecting DLB and has a role in differentiating DLB from ADD, especially in Items 1 and 4.

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“…This pattern was centered on posterior brain regions but also involved anterior regions, including the frontal lobes, which might account for the attentional/frontal deficits of this clinical phenotype. Interestingly, abnormal visual-attention metabolic connectivity has also been observed in LBD, a pathology with predominant alterations in visual perception (Zorzi et al, 2021). Disruption of these so-called "top-down" pathways may be the mechanism underlying simultanagnosia and visual hallucinations.…”

Section: Functional Connectivity In Posterior Cortical Atrophymentioning

confidence: 99%

Breakdown of specific functional brain networks in clinical variants of Alzheimer’s disease

Pini

Wennberg

Salvalaggio

et al. 2021

Ageing Research Reviews

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Changes of Metabolic Connectivity in Dementia with Lewy Bodies with Visual Hallucinations: A ¹⁸F-Fluorodeoxyglucose Positron Emission Tomography/Magnetic Resonance Study

Cited by 5 publications

References 35 publications

EANM procedure guidelines for brain PET imaging using [18F]FDG, version 3

EANM procedure guidelines for brain PET imaging using [18F]FDG, version 3

The gesture imitation test in dementia with Lewy bodies and Alzheimer's disease dementia

Breakdown of specific functional brain networks in clinical variants of Alzheimer’s disease

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Changes of Metabolic Connectivity in Dementia with Lewy Bodies with Visual Hallucinations: A 18F-Fluorodeoxyglucose Positron Emission Tomography/Magnetic Resonance Study

Cited by 5 publications

References 35 publications

EANM procedure guidelines for brain PET imaging using [18F]FDG, version 3

EANM procedure guidelines for brain PET imaging using [18F]FDG, version 3

The gesture imitation test in dementia with Lewy bodies and Alzheimer's disease dementia

Breakdown of specific functional brain networks in clinical variants of Alzheimer’s disease

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Product

Resources

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Changes of Metabolic Connectivity in Dementia with Lewy Bodies with Visual Hallucinations: A ¹⁸F-Fluorodeoxyglucose Positron Emission Tomography/Magnetic Resonance Study