Changes of learning, memory and levels of CaMKII, CaM mRNA, CREB mRNA in the hippocampus of chronic multiple-stressed rats

Sun, Chao; Qi, Shuangshuang; Lou, Xinfa; Sun, Siyuan; Wang, Xin; Dai, Kai-yu; Hu, Siwang; Liu, Neng-bao

doi:10.1097/00029330-200601020-00008

Cited by 28 publications

(13 citation statements)

References 24 publications

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“…Most studies reported cognitive impairment in stressed animals Song et al 2006). However, some research pointed to an improvement in MWM task after exposure to stress (Gouirand and Matuszewich 2005;Sun et al 2006). Two explanations for these contrary results have been suggested: (1) early exposure to stress facilitate the animals adaptation to a stressful conditions such as MWM (Pham et al 1997); (2) the contradiction may be due to the use of different memory tests and stress paradigms that are based on different neuron circuits (Naudon et al 2007).…”

Section: Discussionmentioning

confidence: 99%

The Effects of Fluoxetine Treatment in a Chronic Mild Stress Rat Model on Depression-Related Behavior, Brain Neurotrophins and ERK Expression

et al. 2011

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Depression is associated with hippocampus (HC) volume loss. Chronic mild stress (CMS) in rats is a model of depression. Antidepressants attenuate HC volume loss and reverse the depression-like symptoms of stressed animals. We evaluated the effect of CMS and the selective serotonin reuptake inhibitor, fluoxetine (FLX) treatment on behavioral and cognitive parameters in rats, and on HC and frontal cortex (FC) neurotrophic factors levels. Male rats were exposed sequentially, over a period of 5 weeks, to a variety of mild stressors. FLX (5 mg/kg/day ip) was administered to the stressed group and controls (unstressed). After 5 of CMS, animals were tested using the Morris Water Maze (MWM). In the MWM, we observed that FLX had a transitory effect on unstressed rats. CMS reduced insulin-like growth factor-1 receptor (IGF-1R) levels in the HC whereas after FLX treatment these levels reverted to normal range. CMS rats revealed a significant decrease in extracellular signal-regulated kinase (ERK) phosphorylation in both HC and FC regions, while FLX normalized these levels. This study suggests that IGF-1R and ERK may have a role in mediating the neural stress response and the mode of action of FLX. This role seems to be independent of the BDNF alterations.

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Section: Discussionmentioning

confidence: 99%

The Effects of Fluoxetine Treatment in a Chronic Mild Stress Rat Model on Depression-Related Behavior, Brain Neurotrophins and ERK Expression

et al. 2011

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“…Previous studies showed, for example, that Camk2a levels were increased in the hippocampus of stressed rats and in anxiety response (Koks et al . 2004; Sun et al . 2006).…”

Section: Gene Expression Profiling: Comparison Between Msp and Non‐sementioning

confidence: 99%

REVIEW: Genetically selected Marchigian Sardinian alcohol‐preferring (msP) rats: an animal model to study the neurobiology of alcoholism

et al. 2006

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The present article provides an up-to-date review that summarize almost 18 years of research in genetically selected Marchigian Sardinian alcohol-preferring (msP) rats. The results of this work demonstrate that msP rats have natural preference for ethanol characterized by a spontaneous binge-type of drinking leading to pharmacologically significant blood ethanol levels. This rat line is highly vulnerable to relapse and presentation of stimuli predictive of alcohol availability or footshock stress can reinstate extinguished drug-seeking up to 8 months from the last alcohol experience. The msP rat is highly sensitive to stress, shows an anxious phenotype and has depressive-like symptoms that recover following ethanol drinking. Interestingly, these animals have an up-regulated corticotrophin releasing factor (CRF) receptor 1 system. From clinical studies we learned that alcoholic patients often drink ethanol in the attempt to self-medicate from negative affective states and to search anxiety relief. We propose that msP rats represent an animal model that largely mimics that human alcoholic population that due to low ability to engage in stress-coping strategies drink ethanol as a tension relief strategy and for self-medication purposes.

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“…Many cell receptors trigger signal cascades that focus on CREB to modulate gene expression, and are believed to play a critical role in synapse formation and dendritic development. In addition, studies have shown that increases in CaMKII and CREB mRNA expression in the hippocampus may contribute to the enhancing effect of chronic multiple stress on learning and memory (Sun et al, 2006). Consistent with previous studies, our data clearly showed that PS suppresses the activation of CaMKIIα and CREB in offspring rats (Sun et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…Environmental factors, which have important effects early in life, can permanently alter nervous structure and function throughout life. Prenatal stress (PS), which refers to stress during pregnancy, has been reported to exert a wide variety of negative emotional and behavioral effects on both humans and animal offspring, and these include depression, anxiety, attention deficit hyperactivity disorder, and especially learning and memory deficits (Delany et al, 2016; Goldstein, 2019; Popoli, Yan, McEwen, & Sanacora, 2012; Sun et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Imperatorin ameliorates learning and memory deficits throughBDNF/TrkBandERK/CaMKIIα/CREBsignaling in prenatally‐stressed female offspring

Zheng

Zhang

et al. 2020

Phytotherapy Research

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Prenatal stress (PS) can lead to impaired spatial learning and memory in offspring. Imperatorin (IMP) is a naturally occurring furanocoumarin with many pharmacological properties. However, the effects of IMP on cognitive impairment induced by PS and the underlying molecular mechanisms remain unclear. We investigated the protective effect of IMP treatment after PS on learning and memory deficits in female offspring at postnatal 60 days. After treating prenatally‐stressed offspring with IMP (15 and 30 mg/kg) for 28 days, we found that IMP increased body weight and ameliorated spatial learning and memory and working memory deficits in female offspring rats. Meanwhile, hippocampal Glu and serum corticosterone levels in prenatally‐stressed offspring were significantly decreased after IMP administration. Additionally, IMP treatment significantly increased BDNF, TrkB, CaMKII, and CREB mRNA expression in the hippocampus of offspring rats. Furthermore, PS‐mediated induction of RKIP protein and mRNA expression and glucocorticoid receptor protein expression in the hippocampus of offspring rats were significantly decreased by IMP treatment, and the protein expression of BDNF and TrkB and relative levels of p‐EKR/ERK, p‐CaMKIIα/CaMKIIα, and p‐CREB/CREB were remarkably increased after IMP treatment. Taken together, IMP can ameliorate PS‐induced learning and memory deficits through BDNF/TrkB and ERK/CaMKIIα/CREB signaling pathway and hypothalamic–pituitary–adrenal axis.

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Changes of learning, memory and levels of CaMKII, CaM mRNA, CREB mRNA in the hippocampus of chronic multiple-stressed rats

Cited by 28 publications

References 24 publications

The Effects of Fluoxetine Treatment in a Chronic Mild Stress Rat Model on Depression-Related Behavior, Brain Neurotrophins and ERK Expression

The Effects of Fluoxetine Treatment in a Chronic Mild Stress Rat Model on Depression-Related Behavior, Brain Neurotrophins and ERK Expression

REVIEW: Genetically selected Marchigian Sardinian alcohol‐preferring (msP) rats: an animal model to study the neurobiology of alcoholism

Imperatorin ameliorates learning and memory deficits throughBDNF/TrkBandERK/CaMKIIα/CREBsignaling in prenatally‐stressed female offspring

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