Changes of inter-hemispheric functional connectivity between motor cortices after brachial plexuses injury: A resting-state fMRI study

Liu, B.; Li, T.; Tang, Weijun; Zhang, J.-H.; Sun, Hui; Xu, Wendong; Liu, H.-Q.; Feng, Xiaoyuan

doi:10.1016/j.neuroscience.2013.03.048

Cited by 37 publications

(37 citation statements)

References 22 publications

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“…Preservation of intra hemispheric intrinsic connectivity is in accordance with previous studies in deafferentated rats subsequent to brachial plexus transection 31 and deafferentated humans following brachial plexus injury, 32 stroke 27 or surgical transection of the corpus callosum (callosotomy). 33 The current study, however, demonstrated for the first time in healthy, human adults that inter hemispheric plasticity can be induced in the RSFC brain network utilizing deafferentation through a transient and reversible PNB model used in clinical practice and subsequently imaged utilizing fMRI.…”

Section: Discussionsupporting

confidence: 91%

Changes in Brain Resting-state Functional Connectivity Associated with Peripheral Nerve Block

et al. 2016

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Background Limited information exists on the effects of temporary functional deafferentation (TFD) on brain activity after peripheral nerve block (PNB) in healthy humans. Increasingly, resting-state functional connectivity (RSFC) is being used to study brain activity and organization. The purpose of this study was to test the hypothesis that TFD through PNB will influence changes in RSFC plasticity in central sensorimotor functional brain networks in healthy human participants. Methods The authors achieved TFD using a supraclavicular PNB model with 10 healthy human participants undergoing functional connectivity magnetic resonance imaging before PNB, during active PNB, and during PNB recovery. RSFC differences among study conditions were determined by multiple-comparison–corrected (false discovery rate–corrected P value less than 0.05) random-effects, between-condition, and seed-to-voxel analyses using the left and right manual motor regions. Results The results of this pilot study demonstrated disruption of interhemispheric left-to-right manual motor region RSFC (e.g., mean Fisher-transformed z [effect size] at pre-PNB 1.05 vs. 0.55 during PNB) but preservation of intrahemispheric RSFC of these regions during PNB. Additionally, there was increased RSFC between the left motor region of interest (PNB-affected area) and bilateral higher order visual cortex regions after clinical PNB resolution (e.g., Fisher z between left motor region of interest and right and left lingual gyrus regions during PNB, −0.1 and −0.6 vs. 0.22 and 0.18 after PNB resolution, respectively). Conclusions This pilot study provides evidence that PNB has features consistent with other models of deafferentation, making it a potentially useful approach to investigate brain plasticity. The findings provide insight into RSFC of sensorimotor functional brain networks during PNB and PNB recovery and support modulation of the sensory–motor integration feedback loop as a mechanism for explaining the behavioral correlates of peripherally induced TFD through PNB.

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Section: Discussionsupporting

confidence: 91%

Changes in Brain Resting-state Functional Connectivity Associated with Peripheral Nerve Block

et al. 2016

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“…clude the precentral gyrus, postcentral gyrus, and supplementary motor area. Using seed-based methods to identify the SMN, Liu et al 17 and Min et al 22 found an absence of motor area activity on the side contralateral to the limb affected by BPI. Liu et al 17 found decreased interhemispheric rsFC between motor cortices in patients with BPI.…”

Section: Discussionmentioning

confidence: 99%

“…Using task-based functional MRI (fMRI), transcranial magnetic stimulation, and intraoperative electrophysiological studies, cortical plasticity (or cortical functional reorganization) has been seen in the sensorimotor cortex after PNI and its recovery in humans and in animal experiments. 17,20,29,36 It is now known that after PNI, there is a loss of afferent signals to the sensorimotor cortex and a rapid change in the somatotopic organization of body parts in both the sensory and motor cortices occur. The functions of the surrounding normal cortices encroach on the defunct cortex, OBJECTIVE The authors aimed to understand the alterations of brain resting-state networks (RSNs) in patients with pan-brachial plexus injury (BPI) before and after surgery, which might provide insight into cortical plasticity after peripheral nerve injury and regeneration.…”

mentioning

confidence: 99%

“…Decreased interhemispheric functional connectivity between motor cortices in patients with complete unilateral BPI before surgery, revealed through the use of seed-based rs-fMRI, has been found in a few studies. 17,28 Qiu et al 29 used a seed-based rs-fMRI approach to demonstrate reduced resting-state functional connectivity (rsFC) between the supplementary motor area and motor cortical areas associated with the hand and arm contralateral to the injured side. This improvement over time despite no improvement in motor power was attributed to expansion of the adjacent cortical areas that encroach into the cortical areas that control the hand and arm.…”

mentioning

confidence: 99%

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Cortical plasticity after brachial plexus injury and repair: a resting-state functional MRI study

Bhat¹,

Devi²,

Bharti³

et al. 2017

FOC

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OBJECTIVE The authors aimed to understand the alterations of brain resting-state networks (RSNs) in patients with pan–brachial plexus injury (BPI) before and after surgery, which might provide insight into cortical plasticity after peripheral nerve injury and regeneration. METHODS Thirty-five patients with left pan-BPI before surgery, 30 patients after surgery, and 25 healthy controls underwent resting-state functional MRI (rs-fMRI). The 30 postoperative patients were subdivided into 2 groups: 14 patients with improvement in muscle power and 16 patients with no improvement in muscle power after surgery. RSNs were extracted using independent component analysis to evaluate connectivity at a significance level of p < 0.05 (familywise error corrected). RESULTS The patients with BPI had lower connectivity in their sensorimotor network (SMN) and salience network (SN) and greater connectivity in their default mode network (DMN) before surgery than the controls. Connectivity of the left supplementary motor cortex in the SMN and medial frontal gyrus and in the anterior cingulate cortex in the SN increased in patients whose muscle power had improved after surgery, whereas no significant changes were noted in the unimproved patients. There was a trend toward reduction in DMN connectivity in all the patients after surgery compared with that in the preoperative patients; however, this result was not statistically significant. CONCLUSIONS The results of this study highlight the fact that peripheral nerve injury, its management, and successful treatment cause dynamic changes within the brain's RSNs, which includes not only the obvious SMN but also the higher cognitive networks such as the SN and DMN, which indicates brain plasticity and compensatory mechanisms at work.

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“…In adults, a peripheral nerve injury in the forearm or a brachial plexus injury is known to result in substantial reorganization in sensorimotor areas in both brain hemispheres—and also in changes in functional connectivity between sensorimotor areas (11, 25). In addition, the return of sensory and motor functions after these injuries is often poor (26).…”

Section: Discussionmentioning

confidence: 99%

Cerebral Reorganization in Patients with Brachial Plexus Birth Injury and Residual Shoulder Problems

et al. 2016

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The functional outcome after a brachial plexus birth injury (BPBI) is based on changes in the peripheral nerve and in the central nervous system. Most patients with a BPBI recover, but residual deficits in shoulder function are not uncommon. The aim of this study was to determine cerebral activation patterns in patients with BPBI and also residual symptoms from the shoulder. In seven patients (six females and one male, aged 17–23 years) with a BPBI and residual shoulder problems (Mallet score IV or lower), the cerebral response to active movement of the shoulder and elbow of the injured and healthy arm was monitored using functional magnetic resonance imaging at 3 T. Movements, i.e., shoulder rotation or elbow flexion and extension, of the injured side resulted in a more pronounced and more extended activation of the contralateral primary sensorimotor cortex compared to the activation seen after moving the healthy shoulder and elbow. In addition, moving the shoulder or elbow on the injured side resulted in increased activation in ipsilateral primary sensorimotor areas an also increased activation in associated sensorimotor areas, in both hemispheres, located further posterior in the parietal lobe, which are known to be important for integration of motor tasks and spatial aspects of motor control. Thus, in this preliminary study based on a small cohort, patients with BPBI and residual shoulder problems show reorganization in sensorimotor areas in both hemispheres of the brain. The increased activation in ipsilateral sensorimotor areas and in areas that deal with both integration of motor tasks and spatial aspects of motor control in both hemispheres indicates altered dynamics between the hemispheres, which may be a cerebral compensation for the injury.

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Changes of inter-hemispheric functional connectivity between motor cortices after brachial plexuses injury: A resting-state fMRI study

Cited by 37 publications

References 22 publications

Changes in Brain Resting-state Functional Connectivity Associated with Peripheral Nerve Block

Changes in Brain Resting-state Functional Connectivity Associated with Peripheral Nerve Block

Cortical plasticity after brachial plexus injury and repair: a resting-state functional MRI study

Cerebral Reorganization in Patients with Brachial Plexus Birth Injury and Residual Shoulder Problems

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