Changes of hydration of rats' tissues after in vivo exposure to 0.2 Tesla steady magnetic field

2012

Bioelectromagnetics

The reason for hyper magnetosensitivity of young animals compared to older ones remains unclear. It has been suggested that age-induced tissue dehydration (decreased water content) could be a basis for the aging-related decrease in the organism's magnetosensitivity. To test this hypothesis, the effect of a 0.2 T static magnetic field (SMF) exposure on heart muscle hydration in three age groups of rats (young, adult, and older) was studied, with and without ouabain poisoning. The SMF exposure resulted in heart muscle dehydration of young (21%) and adult (6.2%) rats but had no effect on older animals. In young animals without ouabin poisoning, SMF exposure caused dehydration of the heart muscle while in the ouabain-poisoned animals it led to hydration (29.6%). These hydration effects were more pronounced in young animals than in adult and older animals. The increased hydration (5.7%) of heart muscles in older animals was evoked by providing distilled water for seven days, which elevated (by 12%) the SMF-induced heart muscle hydration effect. These results suggest that the hyper magnetosensitivity of the young heart muscle and the lower sensitivity of older animals are due to initial high (83.5%) and low (75.3%) tissue hydration levels, respectively. Therefore, the age-induced decrease in the magnetosensitivity of heart muscle is likely to be a result of Na(+)/K(+) pump dysfunction.

Section: Resultssupporting

confidence: 57%

Age‐dependent magnetosensitivity of heart muscle hydration

Narinyan

2012

Bioelectromagnetics

“…Moreover, it is known that, because of intracellular macromolecules functioning in aqua medium, the cell hydration plays also a key role in the regulation of their functional activity (Parseghyan et al 2000). On the basis of these data, we have suggested that abnormal cell hydration is an important factor in the generation of pain (nociceptive) signals in nerve terminals and has an important role in other forms of cell pathology (including cancer, nervous, and cardiovascular disorders) (Ayrapetyan 1998;Danielian et al 1999). Therefore, the cell hydration was suggested as a potential cellular marker through which the biological effect of different environmental factors are realized.…”

mentioning

confidence: 92%

Cell hydration as a universal marker for detection of environmental pollution

2012

Environmentalist

At present, when the technological progress brings progressive increase in environmental pollutions by different chemical and physical (ionizing and non-ionizing radiations) factors, the detection of the safety of environmental medium from the point of public health is one of the fundamental problems of modern Life Sciences. This problem has especially disquieting character after the Chernobyl and Japan nuclear catastrophes, when the level of background ionizing radiation and chemical pollutions of environmental medium of the number of world's regions are increased beyond safety doses. As the biological effect of weak environmental factors have nonlinear dosedependent character, besides its thermodynamic characteristics it depends also on environmental composition and initial state of organism. Therefore, the current policy of World Health Organization and other international organizations whose mission is to establish safety standards for environmental pollutions by chemical and physical factors, based only on the their concentration or energy absorption rate by organism cannot be considered as adequate. It is suggested that the biological marker having universal sensitivity to different factors and determining the functional state of organisms could be used for estimation of the safety doses of environmental factors on organism. In present review are presented the data consisting of the hypothesis according to which the Na/K pump and Na/Cacontrolling cell hydration could serve as a universal and extra-sensitive cellular marker for detection of hazardous effect of environmental pollutions.

“…It was previously shown that SMF exposure had dehydration effects on different cells of rats (Danielian and Ayrapetyan, 1999). Therefore, NIR-treated PS effect on potential-activated ionic current and agonist activated ionic current through the membrane in isolated neurons of snails was studied Hunanyan and Ayrapetyan, 2007).…”

Section: Nir-treated Physiological Solution (Ps) Effect On Functionalmentioning

confidence: 99%

The role of cell hydration in realization of biological effects of non-ionizing radiation (NIR)

Electromagnetic Biology and Medicine

2015

The weak knowledge on the nature of cellular and molecular mechanisms of biological effects of NIR such as static magnetic field, infrasound frequency of mechanical vibration, extremely low frequency of electromagnetic fields and microwave serves as a main barrier for adequate dosimetry from the point of Public Health. The difficulty lies in the fact that the biological effects of NIR depend not only on their thermodynamic characteristics but also on their frequency and intensity "windows", chemical and physical composition of the surrounding medium, as well as on the initial metabolic state of the organism. Therefore, only biomarker can be used for adequate estimation of biological effect of NIR on organisms. Because of the absence of such biomarker(s), organizations having the mission to monitor hazardous effects of NIR traditionally base their instruction on thermodynamic characteristics of NIR. Based on the high sensitivity to NIR of both aqua medium structure and cell hydration, it is suggested that cell bathing medium is one of the primary targets and cell hydration is a biomarker for NIR effects on cells and organisms. The purpose of this article is to present a short review of literature and our own experimental data on the effects of NIR on plants' seeds germination, microbe growth and development, snail neurons and heart muscle, rat's brain and heart tissues.